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Baker Institute for Animal Health

DEDICATED TO THE STUDY OF VETERINARY INFECTIOUS DISEASES, IMMUNOLOGY, CANCER, REPRODUCTION, GENOMICS AND EPIGENOMICS

Baker Institute Publications Fiscal Year 2022

June 2022

Maria BottermannSarah L Caddy. Virus neutralisation by intracellular antibodies. Semin Cell Dev Biol.  2022 Jun;126:108-116.

DOI: 10.1016/j.semcdb.2021.10.010

PMID: 34782185

Julie MenardRobert GoggsPatrick MitchellYufan Yang , Sarah Robbins , Rebecca J Franklin-GuildAnil J Thachil , Craig AltierRenee AndersonGregory G PutzelHolly McQuearyLaura B Goodman. Effect of antimicrobial administration on fecal microbiota of critically ill dogs: dynamics of antimicrobial resistance over time. Anim Microbiome. 2022 Jun 4;4(1):36.

DOI: 10.1186/s42523-022-00178-9

PMID: 35659110

PMCID: PMC9167539

Genevieve R Meredith , Marwan Osman , Casey L Cazer , Kevin J Cummings , Jason Hecht , Cecelia G Madsen , Laura B Santacrose , Abigail S Dubovi , Marin Clarkberg , Tyler Johnson , Maria D Fitzpatrick , Lara Parrilla , Yihong Li , Lorraine Francis , Isaac B Weisfuse , Alexander J Travis, Anne C Jones , Lorin D Warnick , Gary A Koretzky. Integrated surveillance system for controlling COVID-19 on a university campus, 2020-2021, Notes from the Field, American Journal of Public Health.

DOI: 10.2105/AJPH.2022.306838

PMID: 35728024

PMCID: PMC9222446 (available on 2024-07-01)

Kevin J. Cummings, Clarkberg, M., Busche, J. Alexander J. Travis, G.R. Meredith, I. Weisfuse, Casey L. Cazer, G.A. Koretzky and Lorin D. Warnick (2022) Case-control study to identify risk factors for SARS-CoV-2 infection among university students. Transbound Emerg Dis.  2022 Jun 10;10.1111/tbed.14619.

DOI: 10.1111/tbed.14619

PMID: 35687478

PMCID: PMC9348057

John J Erickson, Stephanie Archer-Hartmann, Alexander E Yarawsky, Jeanette L C Miller, Stephanie Seveau, Tzu-Yu Shao, Ashley L Severance, Hilary Miller-Handley, Yuehong Wu, Giang Pham, Brian R Wasik, Colin R Parrish, Yueh-Chiang Hu, Joseph T Y Lau, Parastoo Azadi, Andrew B Herr, Sing Sing Way. Pregnancy enables antibody protection against intracellular infection. Nature. 2022 Jun;606(7915):769-775.

doi: 10.1038/s41586-022-04816-9

PMID: 35676476

PMCID: PMC9233044

May 2022

Manuel Ruiz-Aravena , Clifton McKee, Amandine Gamble, Tamika Lunn, Aaron Morris, Celine E Snedden , Claude Kwe Yinda , Julia R Port , David W Buchholz , Yao Yu Yeo , Christina Faust, Elinor Jax , Lauren Dee , Devin N Jones  Maureen K Kessler, Caylee Falvo, Daniel Crowley, Nita Bharti, Cara E Brook, Hector C Aguilar, Alison J Peel, Olivier Restif, Tony Schountz, Colin R Parrish, Emily S Gurley, James O Lloyd-Smith, Peter J Hudson, Vincent J Munster, Raina K Plowright. Ecology, evolution and spillover of coronaviruses from bats. Nat Rev Microbiol. 2022 May;20(5):299-314.

doi: 10.1038/s41579-021-00652-2

PMID: 34799704

PMCID: PMC8603903

April 2022

Arianna P. Bartlett, Rebecca M. Harman, Jennifer R. Weiss, Gerlinde R. Van de Walle. (2022). Establishment and characterization of equine mammary organoids using a method translatable to other non-traditional model species. In collection: Reproductive biology. Techniques and Resources. 12 April 2022

DOI: 10.1242/dev.200412

PMID: 35297994

Funding Information:

This work was funded by a Cornell University Feline Health Center (FHC) grant and by funding from the Albert C Bostwick Foundation to Gerlinde R. Van de Walle and Arianna P. Bartlett was supported by a Liz Hanson Graduate Fellowship.

Malgorzata Rychlowska, Abigail Agyapong, Michael Weinfeld, Luis M Schang (2022). Zika Virus Induces Mitotic Catastrophe in Human Neural Progenitors by Triggering Unscheduled Mitotic Entry in the Presence of DNA Damage While Functionally Depleting Nuclear PNKP. J Virol.  2022 Apr 12;e0033322. 

DOI: 10.1128/jvi.00333-22

PMID: 35412344

Funding Information:

These studies were funded by the NIH National Institute of Neurological Disorders and Stroke (5R21NS111416) and Canadian Institutes of Health Research (PJT168869).

Tinyi Chu, Zhong Wang, Dana Pe’er, Charles G. Danko (2021). Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology. Nature Cancer. 25 Apr 2022.

DOI: 10.1101/2020.01.07.897900

Funding Information:

Work in this publication was supported by R01-HG009309 (NHGRI) to Charles G. Danko, U2C-CA288284 (NCI) and U54-CA209975 (NCI) to Dana Pe’er, and P30-CA008748 to Tinyi Chu.

Jordan D Zehr, Sergei L. Kosakovsky Pond, Darren P Martin, Kristina Ceres, Gary R Whittaker, Jean K. Millet, Laura B Goodman, Michael J. Stanhope (2022). Recent zoonotic spillover and tropism shift of a Canine Coronavirus is associated with relaxed selection and putative loss of function in NTD subdomain of spike protein. Viruses. 21 April 2022. 14(5), 853.

DOI: 10.1101/2021.11.15.468709

Funding Information:

This study received funding from the U.S. Food and Drug Administration’s Veterinary Laboratory Investigation and Response Network (FDA Vet-LIRN) under grant 1U18FD006993-01, awarded to Laura B Goodman and Michael J. Stanhope. Sergei L. Kosakovsky Pond and Jordan D Zehr were supported in part by grants R01 AI134384 (NIH/NIAID) and U01 GM110749 (NIH/NIGMS).

Salla Mattola, Kari Salokas, Vesa Aho, Elina Mäntylä , Sami Salminen, Satu Hakanen, Einari A Niskanen, Julija Svirskaite, Teemu O Ihalainen, Kari J Airenne, Minna Kaikkonen-Määttä, Colin R Parrish, Markku Varjosalo, Maija Vihinen-Ranta. Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins. PLoS Pathog. 2022 Apr 8;18(4):e1010353.

DOI: 10.1371/journal.ppat.1010353

PMID: 35395063

PMCID: PMC9020740

March 2022

Sarah M Bell, Jacquelyn M Evans, Katy M Evans, Kate L Tsai, Rooksana E Noorai, Thomas R Famula, Dolores M Holle, Leigh Anne Clark (2022). Congenital idiopathic megaesophagus in the German shepherd dog is a sex-differentiated trait and is associated with an intronic variable number tandem repeat in Melanin-Concentrating Hormone Receptor 2. PLoS Genet. 2022 Mar 10;18(3):e1010044.

DOI: 10.1371/journal.pgen.1010044

PMID: 35271580

PMCID: PMC8912139

Funding Information:

This work was supported in part by grants to Leigh Anne Clark from the Collie Health Foundation and the American Kennel Club (AKC) Canine Health Foundation, as well as a donation by the Upright Canine Brigade. Sarah M Bell was supported by an AKC Canine Health Foundation Clinician-Scientist Fellowship (02654-E) sponsored by the Orthopedic Foundation for Animals. Rooksana E Noorai was supported by an Institutional Development Award from the National Institute of General Medical Sciences of the National Institutes of Health/NIGMS.

Roy Cohen, Chinatsu Mukai, Jacquelyn L. Nelson, Shoshana S. Zenilma, Danielle M. Sosnicki, Alexander J. Travis. (2022). A Genetically-targeted sensor reveals spatial and temporal dynamics of acrosomal calcium and sperm acrosome exocytosis. J Biol Chem. 2022 Mar 25;101868.

DOI: 10.1016/j.jbc.2022.101868

PMID: 35346690

Funding Information:

This work was supported by National Institutes of Health grants R01-HD093827 and R03-HD090304 (Alex Travis) and the Cornell-Smithsonian Joint Graduate Training Program for author training and support (Danielle Sosnicki).

Zhong Wang, Alexandra G Chivu, Lauren A Choate, Edward J Rice, Donald C Miller, Tinyi Chu, Shao-Pei Chou, Nicole B Kingsley Jessica L Petersen, Carrie J Finno, Rebecca R Bellone, Douglas F Antczak, John T Lis, Charles G Danko (2022). Prediction of histone post-translational modification patterns based on nascent transcription data. Nat Genet. 2022 Mar;54(3):295-305.

DOI: 10.1038/s41588-022-01026-x

PMID: 35273399

Funding Information:

Work in this publication was supported by the National Human Genome Research Institute (grant R01-HG009309 to Charles G. Danko), the Zweig Memorial Fund for Equine Research (grant to Doug F. Antczak and Charles G. Danko), the LiaoNing Revitalization Talents Program (grant XLYC2002010 to Zhong Wang) and the National Institutes of Health (grant RM1GM139738 to John T. Lis).

Gilad Barshad, Lauren M Webb, Hung-An Ting, Oyebola O Oyesola, Oluomachi G Onyekwere, James J Lewis, Edward J Rice, Macy K Matheson, Xiao-Hong Sun, Jakob von Moltke, Charles G Danko, Elia D Tait Wojno (2022). E-Protein Inhibition in ILC2 Development Shapes the Function of Mature ILC2s during Allergic Airway Inflammation. J Immunol. 2022 Mar 1;208(5):1007-1020.

DOI: 10.4049/jimmunol.2100414

PMID: 35181641

PMCID: PMC8881320

Funding Information:

This work was supported by startup funds from the University of Washington and Cornell University (to Elia D. Tait Wojno), National Institute of Allergy and Infectious Diseases Grants K22 AI116729, R01 AI132708, and R01 AI130379 (to Elia D. Tait Wojno), National Institutes of Health Grant R01 AI126851 (to Xiao-Hong Sun), and National Human Genome Research Institute Grant R01 HG010346 (to Charles G. Danko). Jakob von Moltke. is a Searle Scholar, and work in his laboratory is supported by National Institutes of Health Grant 1DP2 OD024087.

Tirosh Shapira, I Abrrey Monreal, Sébastien P Dion, David W Buchholz, Brian Imbiakha, Andrea D Olmstead, Mason Jager, Antoine Désilets, Guang Gao, Mathias Martins, Thierry Vandal, Connor A H Thompson, Aaleigha Chin, William D Rees, Theodore Steiner, Ivan Robert Nabi, Eric Marsault, Julie Sahler, Diego G Diel, Gerlinde R Van de Walle, Avery August, Gary R Whittaker, Pierre-Luc Boudreault, Richard Leduc, Hector C Aguilar, François Jean (2022). A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic. Nature, 2022 Mar 28. Epub ahead of print.

DOI: 10.1038/s41586-022-04661-w

PMID: 35344983

Funding Information:

This work was supported by operating grants from the Canadian 2019 Novel Coronavirus (COVID-19) Rapid Research Funding program of the Canadian Institutes of Health Research (CIHR) [UBR 322812; VR3-172639 (Richard Leduc, Pierre-Luc Boudreault, and François Jean) and OV3-170342 (François Jean)]; by a Genome British Columbia / COVID-19 Rapid Response Funding Initiative [COV011 (François Jean)]; by the Coronavirus Variants Rapid Response Network [175622 (François Jean and Andrea D Olmstead)]; by a Cornell University Seed Grant, Cornell University start-up funds and a George Mason University, Mercatus Center; Emergent Ventures Fast Grant (HAC); by a National Institutes of Health research grant [R01AI35270 (Gary Whittaker)]; by a MITACS Accelerate Fellowship [IT18555 (William D Rees)]; an NIH training grant [T32EB023860 (Avery August to support David W Buchholz) and R25GM125597 (Avery August to support Brian Imbiakha)], by an NIH R01 [AI138570 (Avery August)]; by a CIHR Frederick Banting and Charles Best Canada Graduate Scholarship Award [167018 (Sébastien P Dion)]; by a PROTEO graduate scholarship (Thierry Vandal); and by a MITACS Inc. Accelerate fellowship COVID-19 Award [IT18585 (Tirosh Shapira)

Claire H Birkenheuer, Laura Dunn, Rachel Dufour, Joel D Baines (2022). ICP22 of Herpes Simplex Virus 1 Decreases RNA Polymerase Processivity. J Virol. 2022 Mar 9;96(5):e0219121.

DOI: 10.1128/jvi.02191-21

PMID: 35019725

PMCID: PMC8906429 (available on 2022-09-09)

Funding Information:

These studies were supported by National Institutes of Health grants R01 AI 141968 and R21 AI 148926 to Joel D Baines., and training grant T35 OD 11151 to Rachel Dufour.

February 2022

Patrick K Mitchell, Leyi Wang, Bryce J Stanhope, Brittany D Cronk, Renee Anderson, Shipra Mohan, Lijuan Zhou, Susan Sanchez, Paula Bartlett, Carol Maddox, Vanessa DeShambo, Rinosh Mani, Lindsy M Hengesbach, Sarah Gresch, Katie Wright, Sunil Mor, Shuping Zhang, Zhenyu Shen, Lifang Yan, Rebecca Mackey, Rebecca Franklin-Guild, Yan Zhang, Melanie Prarat, Katherine Shiplett, Akhilesh Ramachandran, Sai Narayanan, Justin Sanders, Andree A Hunkapiller, Kevin Lahmers, Amanda A Carbonello, Nicole Aulik, Ailam Lim, Jennifer Cooper, Angelica Jones, Jake Guag, Sarah M Nemser, Gregory H Tyson, Ruth Timme, Errol Strain, Renate Reimschuessel, Olgica Ceric, Laura B Goodman . (2022). Multi-laboratory evaluation of the Illumina iSeq platform for whole genome sequencing of Salmonella, Escherichia coli and Listeria. Microb Genom. 2022 Feb;8(2):000717

DOI: 10.1099/mgen.0.000717

PMID: 35113783

PMCID: PMC8942033

Funding Information:

This study was funded and performed in collaboration with the Food and Drug Administration’s Veterinary Laboratory Investigation and Response Network (FDA Vet-LIRN) under cooperative agreements 1U18FD006714-01 to Laura Goodman.

Aitor Nogales, Kevin Chiem, Michael Breen, Marta L DeDiego, Colin R Parrish, Luis Martínez-Sobrido (2022). Generation and Characterization of Single-Cycle Infectious Canine Influenza A Virus (sciCIV) and Its Use as Vaccine Platform. Vaccine Technologies for Veterinary Viral Diseases pp 227-255.

DOI: 10.1007/978-1-0716-2168-4_13

PMID: 35118625        

Funding Information:

No funding support this book chapter.

January 2022

Taylorlyn Stephan, Shawn M Burgess , Hans Cheng , Charles G Danko , Clare A Gill, Erich D Jarvis, Klaus-Peter Koepfli, James E Koltes, Eric Lyons, Pamela Ronald, Oliver A Ryder, Lynn M Schriml, Pamela Soltis, Sue VandeWoude, Huaijun Zhou, Elaine A Ostrander, Elinor K Karlsson (2022). Darwinian genomics and diversity in the tree of life. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2115644119

DOI: 10.1073/pnas.2115644119

PMID: 35042807

PMCID: PMC8795533

Funding Information:

The workshop Perspectives in Comparative Genomics and Evolution was supported by the National Human Genome Research Institute’s 2020 Strategic Planning process and the following grants: NSF-1939343, NIFA-AFRI-2019-67015-29490, and NIH GM122968.

Rolfe M Radcliffe, Lauren C Bookbinder, Sharon Y Liu, Joy E Tomlinson, Vanessa L Cook, Samuel D A Hurcombe, Thomas J Divers (2022). Collection and administration of blood products in horses: Transfusion indications, materials, methods, complications, donor selection, and blood testing. J Vet Emerg Crit Care (San Antonio). 2022 Jan;32(S1):108-122.

DOI: 10.1111/vec.13119

PMID: 35044065

Funding Information:

Publication not open access, cannot identify.

Nikoloz Nemanichvili, Alinda J Berends, Ilhan Tomris, Karen N Barnard, Colin R Parrish, Andrea Gröne, Jolianne M Rijks, Monique H Verheije, Robert P de Vries. Influenza D binding properties vary amongst the two major virus clades and wildlife species. Vet Microbiol. 2022  Jan;264:109298.

DOI: 10.1016/j.vetmic.2021.109298

PMID: 34906835

December 2021

Rebecca M Harman, Katherine A Churchill, Mason C Jager, Gerlinde R Van de Walle. (2021). The equine mesenchymal stromal cell secretome inhibits equid herpesvirus type 1 strain Ab4 in epithelial cells. Res Vet Sci.  2021 Dec;141:76-80.

DOI: 10.1016/j.rvsc.2021.10.012

PMID: 34700147

Funding Information:

This work was funded by the Harry M. Zweig Memorial Fund for Equine Research.

Charlotte Marx, Sophia Gardner, Rebecca M Harman, Bettina Wagner, Gerlinde R Van de Walle. (2021). Mesenchymal stromal cell-secreted CCL2 promotes antibacterial defense mechanisms through increased antimicrobial peptide expression in keratinocytes. Stem Cells Transl Med. 2021 Dec;10(12):1666-1679.

DOI: 10.1002/sctm.21-0058

PMID: 34528765

PMCID: PMC8641085

Funding Information:

This study was supported by an Agriculture & Food Research Initiative Competitive Grant no. 2018‐67015‐28309 from the USDA National Institute of Food and Agriculture and a Harry M. Zweig Memorial Fund for Equine Research grant to Gerlinde Van de Walle and a fellowship Grant no. DE20EQ‐406 from the Morris Animal Foundation to Charlotte Marx.

Madhav Mantri, Meleana M. Hinchman, David W. McKellar, Michael F. Z. Wang, Shaun T. Cross, John S. L. Parker, Iwijn De Vlaminck (2021). Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis. BioRxiv. 2021 Dec:9

DOI: 10.1101/2021.12.07.471659.

Funding Information:

This work was supported by R21AI144557 to John S.L. Parker and Iwijn De Vlaminck and

DP2AI138242 (to Iwijn De Vlaminck.). Shaun T. Cross was supported by the National Institutes of Health and National Institute of Allergy and Infectious Diseases Award T32AI145821.

November 2021

Lauren A Choate, Gilad Barshad, Pierce W McMahon, Iskander Said, Edward J Rice, Paul R Munn, James J Lewis, Charles G Danko. (2021). Multiple stages of evolutionary change in anthrax toxin receptor expression in humans. Nat Commun. 2021 Nov 15;12(1):6590.

DOI: 10.1038/s41467-021-26854-z

PMID: 34782625

PMCID: PMC8592990z

Funding Information:

Work in this publication was supported by R01-HG010346 and R01-HG009309 (NHGRI) to Charles Danko and an F31-1AI140050 (NIAID) to Lauren A Choate. The content is solely the responsibility of the authors and does not necessarily represent the official views of the US National Institutes of Health.

Michael J Satlin, Jason Zucker, Benjamin R Baer, Mangala Rajan, Nathaniel Hupert, Luis M Schang, Laura C Pinheiro, Yanhan Shen, Magdalena E Sobieszczyk, Lars F Westblade, Parag Goyal, Martin T Wells, Jorge L Sepulveda, Monika M Safford (2021). Changes in SARS-CoV-2 viral load and mortality during the initial wave of the pandemic in New York City. PLoS One . 2021 Nov 19;16(11):e0257979.

DOI: 10.1371/journal.pone.0257979

PMID: 34797838

PMCID: PMC8604305

Funding Information:

No Cornell or sponsored funds supported this work.

October 2021

Barbara Delvescovo, Joy Tomlinson, Sally DeNottac, Elizabeth Hodged, Lauren Bookbinder, Hussni O. Mohammed, Thomas J.Diversa (2021). Bile Acids, Direct Bilirubin and Gamma-glutamyltransferase as Prognostic Indicators for Horses with Liver Disease in the Eastern United States: 82 Cases (1997-2019). Journal of Equine Vet Sci. Vol. 105, Oct 2021. 103729.

DOI: 10.1016/j.jevs.2021.103729

Funding Information:

No specific grants supported this work.

Kevin J Cummings, Julie D Siler, Noha Abou-Madi, Laura B Goodman, Patrick K Mitchell, Lauren Palena, Sara E Childs-Sanford. (2021). Salmonella Isolated from Central New York Wildlife Admitted to a Veterinary Medical Teaching Hospital.  J Wildl Dis. 2021 Oct 1;57(4):743-748.

DOI: 10.7589/JWD-D-20-00231

PMID: 34424961

Funding Information:

Sequencing capacity used for this study was funded (FOA PAR-18-604) by the US Food and Drug Administration’s Veterinary Laboratory Investigation and Response Network (FDA Vet-LIRN) under grant 1U18FD006716 to Laura B. Goodman.

César Arenas-Mena, Sofija Miljovska, Edward J Rice, Justin Gurges, Tanvi Shashikant, Zihe Wang, Sevinç Ercan, Charles G Danko (2021). Identification and prediction of developmental enhancers in sea urchin embryos. BMC Genomics. 2021 Oct 19;22(1):751.

DOI: 10.1186/s12864-021-07936-0

PMID: 34666684

PMCID: PMC8527612

Funding Information:

This project was funded by NASA to Charles Danko.

Mason C Jager, Joy E Tomlinson, Robert A Lopez-Astacio, Colin R Parrish, Gerlinde R Van de Walle (2021). Small but mighty: old and new parvoviruses of veterinary significance. Virol J. 2021 Oct 24;18(1):210.

DOI: 10.1186/s12985-021-01677-y

PMID: 34689822

PMCID: PMC8542416

Funding Information:

This work was supported by the National Institutes of Health (NIH) under following awards: the Office of the Director under Award number T32ODO011000 to Mason C. Jager and the National Institute of Allergy and Infectious Diseases (NIAID) under Award number K08AI141767 to Joy E. Tomlinson, Award number R01AI092571 to Colin R. Parrish, and Award number 3R01AI092571-08W1 to Robert A. Lopez-Astacio; an Agriculture & Food Research Initiative Competitive Grant number 2020-67015-31297 from the USDA National Institute of Food and Agriculture to Gerlinde R Van de Walle; and a Harry M. Zweig Memorial Fund for Equine Research grant to Gerlinde R Van de Walle.

September 2021

Francesco Cicconardi, James J Lewis, Simon H Martin, Robert D Reed, Charles G Danko, Stephen H Montgomery (2021). Chromosome Fusion Affects Genetic Diversity and Evolutionary Turnover of Functional Loci but Consistently Depends on Chromosome Size. Mol Biol Evol. 2021 Sep 27;38(10):4449-4462.

DOI: 10.1093/molbev/msab185

PMID: 34146107

PMCID: PMC8476138

Funding Information:

This article was supported by NASA 17-EXO-17-2-0112 to Charles G. Danko, NSF IOS-1656514 and DEB-1546049 to Robert D. Reed and an NERC IRF (NE/N014936/1) and ERC Starter Grant (758508) to Stephen H Montgomery was supported by the Royal Society URF\R1\180682.

Joy E Tomlinson, Raphael Wolfisberg, Ulrik Fahnøe, Roosheel S Patel, Sheetal Trivedi, Arvind Kumar Himanshu Sharma, Louise Nielsen, Sean P McDonough, Jens Bukh, Bud C Tennant, Amit Kapoor, Brad R Rosenberg, Charles M Rice, Thomas J Divers, Gerlinde R Van de Walle, Troels K H Scheel (2021). Pathogenesis, MicroRNA-122 Gene-Regulation, and Protective Immune Responses After Acute Equine Hepacivirus Infection. Hepatology. 2021 Sep;74(3):1148-1163

DOI: 10.1002/hep.31802

PMID: 33713356

PMCID: PMC8435542

Funding Information:

Supported by grants from the Agriculture and Food Research Initiative competitive grant no. 2016‐67015‐24765 from the USDA National Institute of Food and Agriculture, the Jack Lowe Equine Health Funds/Mollie Wilmot Equine Research Fund, the European Research Council (ERC Starting Grant 802899 to Troels K H Scheel), Independent Research Fund Denmark (6110‐00595 and 6111‐00314 to Troels K H Scheel. and 4004‐00598 to Jens Bukh), the Novo Nordisk Foundation (NNF15OC0017404 to Troels K H Scheel and NNF18OC0055462 to Jens Bukh), the Lundbeck Foundation (R192‐2015‐1154 to Troels K H Scheel), the Danish Cancer Society (R204‐A12639 to Jens Bukh), and the Weimann Foundation (to Troels K H Scheel. and Ulrik Fahnøe). Joy Tomlinson was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award no. K08AI141767. Raphael Wolfisberg. was supported by an Early Postdoc.Mobility Fellowship (P2BEP3_178527) and a Postdoc.Mobility Fellowship (P400PB_183952) from the Swiss National Science Foundation.

August 2021

Yixin Zhao, Noah Dukler, Gilad Barshad, Shushan Toneyan, Charles G Danko, Adam Siepel (2021). Deconvolution of Expression for Nascent RNA sequencing data (DENR) highlights pre-RNA isoform diversity in human cells. Bioinformatics. 2021 Aug 11;37(24):4727-4736.

DOI: 10.1093/bioinformatics/btab582

PMID: 34382072

PMCID: PMC8665767

Funding Information:

This research was supported, in part, by US National Institutes of Health grants [R35-GM127070, R01-HG009309] and by the Simons Center for Quantitative Biology at Cold Spring Harbor Laboratory.

Christopher H Lee, Krishnan Raghunathan, Gwen M Taylor, Andrea J French, Raquel Tenorio, Isabel Fernández de Castro, Cristina Risco, John S L Parker, Terence S Dermody (2021). Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles. mBio. 2021 Aug 31;12(4):e0140821.

DOI: 10.1128/mBio.01408-21

PMID: 34225484

PMCID: PMC8406312

Funding Information:

This work was supported by Public Health Service awards R01 AI121216 (John S.L. Parker) and R01 AI032539 (Cristina Risco and Terence Dermody), UPMC Children’s Hospital of Pittsburgh (Krishnan Raghunathan), and the Heinz Endowments (Terence S Dermody).

Luis M Schang, MiYao Hu, Esteban Flores Cortes, Kairui Sun (2021). Chromatin-mediated epigenetic regulation of HSV-1 transcription as a potential target in antiviral therapy. Antiviral Res. 2021 Aug;192:105103.

DOI: 10.1016/j.antiviral.2021.105103

PMID: 34082058

PMCID: PMC8277756

Funding Information:

This research is supported by NIH/NIAID 1R01AI153396, NIH/NINSD 5R21NS111416, a Fast Grant, NIH 3UM1HG009393 to Luis Schang.

July 2021

Yingying Guo, Meleana M Hinchman, Mercedes Lewandrowsk, Shaun T Cross, Danica M Sutherland, Olivia L Welsh, Terence S Dermody  John S L Parker. (2021). The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury. PLoS Pathog. 2021 Jul 8;17(7):e1009494.

DOI: 10.1371/journal.ppat.1009494

PMID: 34237110

PMCID: PMC8291629

Funding Information:

This research was supported by NIH grants R01AI121216 to John S.L. Parker and AI038296 to Terrance Dermondy from the National Institute of Allergy and Infectious Diseases. Shaun T Cross was funded through the Cornell Institute of Host-Microbe Interactions and Disease (CIHMID) and NIH grant T32 AI145821.

Kaiping Deng, Steffen Uhlig, Hon S Ip, Mary Lea Killian, Laura B Goodman, Sarah Nemser, Jodie Ulaszek, Shannon Pickens, Robert Newkirk, Matthew Kmet, Kirstin Frost, Karina Hettwer, Bertrand Colson, Kapil Nichani, Anja Schlierf, Andriy Tkachenko, Ravinder Reddy, Renate Reimschuessel. (2022). Interlaboratory comparison of SARS-CoV2 molecular detection assays in use by U.S. veterinary diagnostic laboratories. J Vet Diagn Invest. 2021 Nov;33(6):1039-1051.

DOI: 10.1177/10406387211029913

PMID: 34293974

PMCID: PMC8532215

Funding Information:

No Cornell or sponsored funds supported this work.

James J Lewis, Francesco Cicconard, Simon H Martin, Robert D Reed, Charles G Danko, Stephen H Montgomery (2021). The Dryas iulia Genome Supports Multiple Gains of a W Chromosome from a B Chromosome in Butterflies. Genome Biol Evol. 2021 Jul 6;13(7):evab128.

DOI: 10.1093/gbe/evab128

PMID: 34117762

PMCID: PMC8290107

Funding Information:

This research was supported by NASA 17-EXO-17-2-0112 to Charles G. Danko, NSF IOS-1656514 and DEB-1546049 to Robert D. Reed and a NERC IRF (NE/N014936/1) and ERC Starter Grant (758508) to Stephen H. Montgomery. Simon Martin was supported by the Royal Society URF\R1\180682.

Rebecca M Harman, Christine L Theoret, Gerlinde R Van de Walle (2021). The Horse as a Model for the Study of Cutaneous Wound Healing. Adv Wound Care (New Rochelle). 2021 Jul;10(7):381-399.

DOI: 10.1089/wound.2018.0883

PMID: 34042536

Funding Information:

Gerlinde Van de Walle is supported by the Harry M. Zweig Memorial Fund for Equine Research at Cornell University and by the Agriculture and Food Research Initiative Competitive Grant no. 2018-67015-28309 from the UDSA National Institute of Food and Agriculture. Christine L. Theoret is supported by Natural Sciences and Engineering Research Council of Canada (NSERC grant No. 250231).

Dermody Terence S., Parker John S.L., & B. Sherry. Orthoreoviruses. (2021) In Fields Virology, 7th Edition (In Press). Eds. Damania, Knipe, Whelan, and Howley.

Funding Information:

Not applicable.