Efficacy of endo- and ecto-parasiticides

Parasitic zoonoses of both public health and agricultural importance

Epidemiology of parasites

PhD Animal Science (Cornell University)

Dr. Jennifer Ketzis received her PhD from Cornell University, where she focused on international livestock production and the use of medicinal plants to control Haemonchus contortus in goats. She then took a position at Novartis Animal Health in Switzerland working on the development of natural based products and endo and ectoparasiticides. In 2005, as a Senior Scientist, she established a parasitology laboratory at Charles River Laboratories, Ireland, where she worked with several pharmaceutical companies designing and managing GLP and GCP ecto- and endo-parasite efficacy studies. In 2012, Dr. Ketzis joined Ross University School of Veterinary Medicine. From 2017 to 2022, she served as the coordinator of the MSc and Certificate One Health Program. She currently is the Chair of the RUSVM Institutional Animal Care and Use Committee (IACUC), serves on the Executive Committee of the American Association of Veterinary Parasitologists and is the co-Editor-in-Chief of the journal Veterinary Parasitology: Regional Studies and Reports. She teaches primarily in VMP 5265 Parasitology and in the One Health online program.

Ketzis J. 2021. Case report: Assessment of a quarantine treatment for sheep on the Caribbean island of St. Kitts. VPRSR. https://doi.org/10.1016/j.vprsr.2021.100660

Ketzis J, Bork-Larsen H, Bustria J, Conan A. 2020. Importation of cats and risk of parasite spread: A Caribbean perspective and case study from St Kitts. Parasites & Vectors. 13:488.

Ketzis JK, Lejeune M, Branford I, Beierschmitt A, Willingham AL. 2020. Identification of Schistosoma mansoni infection in a non-human primate from St. Kitts more than 50 years after interruption of human transmission. AJTMH. 103: 2278-2281.

Dantas-Torres F, Ketzis J, Mihalca AD, Baneth G, Otranto D, Tort GP, Watanabe M, Linh BK, Inpankaew T, Jimenez Castro PD, Borrás P, Sangaran A, Penzhorn B, Ybañez AP, Irwin P, Traub RJ. 2020. TroCCAP recommendations for the diagnosis, prevention and treatment of parasitic infections in dogs and cats in the tropics. Vet Parasitol. 283. https://doi.org/10.1016/j.vetpar.2020.109167

Wulcan JM, Dennis MM, Ketzis JK, Bevelock TJ, Verocai GG. 2019. Strongyloides spp. in cats - a review of the literature and the first report of zoonotic Strongyloides stercoralis in colonic epithelial nodular hyperplasia in cats. Vectors and Parasites 12(1):349. doi: 10.1186/s13071-019-3592-7.

Eisenbraun H, Alluwie A, Connolly S, Nair R, Verocaic GG, Ketzis JK. 2019. Comparison of fecal analysis methods for the detection of Platynosomum fastosum in naturally infected cats. Feline Medicine and Surgery. doi.org/10.1177/1098612X19848173

Hobbs EC, Mwape KE, Devleesschauwer B, Van Damme I, Krit M, Berkvens D, Zulu G, Mambwe M, Chembensofu M, Trevisan C, Baauw J, Phiri IK, Speybroeck N, Ketzis J, Dorny P, Willingham AL, Gabriël S. 2019. Effects of ‘The Vicious Worm’ educational tool on Taenia solium knowledge retention in Zambian primary school students after one year. PLOS Neglected Tropical Diseases 3(5):e0007336. doi: 10.1371/journal.pntd.0007336

Pompei Bolfa P, Ketzis J, Marchi S, Kelly P, Cheng T, Huynh H, Lavinder T, Boey K, Hamilton C, Callanan JJ. 2019. Infections and pathology of free-roaming backyard chickens on St. Kitts, West Indies. JVDI 31(3):343-349. doi: 10.1177/1040638719843638

Gallagher C, Beierschmitt A, Cruz K, Choo J, Ketzis J. 2019. Should monkeys wash their hands and feet: a pilot-study on sources of zoonotic parasite exposure. One Health 7:100088. doi: 10.1016/j.onehlt.2019.100088

Geng J, Elsemore D, Oudin N, Ketzis JKK. 2018. Diagnosis of feline whipworm infection using a coproantigen ELISA and the prevalence in feral cats in southern Florida. Vet Parasitol Reg Studies and Reports. 4, 181-186. https://doi.org/10.1016/j.vprsr.2018.11.002

Brandon-Mong G-J, Ketzis J, Yasiri A, Mahboob T, Tian-Chye T, Nissapatorn V. 2018. DNA Barcoding relates Trichuris species from a human and man’s best friend to non-human primate sources. Tropical Biomedicine. 35.

Červená B, Hrazdilová K, Vallo P, Ketzis J, Bolfa P, Tudor E, Lux-Hoppe EG, Blanvillain C, Modrý D. 2018. Mammomonogamus nematodes in felid carnivores: a minireview and the first molecular characterization. Parasitology 1–10. https://doi.org/10.1017/S0031182018000768

Lanthroum CM, Shell L, Neuville K, Ketzis JKK. 2018. Efficacy of praziquantel in the treatment of Platynosomum fastosum in cats with natural infections. Vet Sci 5:35. doi:10.3390/vetsci502003

Ketzis J. 2017. Limitations to the adoption of a standardized Strongyloides stercoralis diagnostic method: case study in the Caribbean. Acta Tropica. 170:178-183. doi: 10.1016/j.actatropica.2017.03.003.

Mitchell G, Ketzis JK, Metzler D, Alvarado Jt, Skuce PJ, Lawton SP. 2023. Identification of Cotylophoron cotylophorum (Fischoeder, 1901) in cattle on St. Kitts, West Indies and its relationship with African and Asian populations. Parasitol Int. 95: 102751

Richins T, Sapp SGH, Ketzis JKK, Willingham AL, Mukaratirwa S, Qvarnstrom Y, Barratt JLN. 2023. Genetic characterization of Strongyloides fuelleborni infecting free-roaming African vervets (Chlorocebus aethiops sabaeus) on the Caribbean island of St. Kitts. International Journal for Parasitology: Parasites and Wildlife. 20: 153-161.

Dantas-Torres F, Ketzis JKK, Mihalca AD, Baneth G, Otranto D, Tort GP, Watanabe M, Linh BK, Inpankaew T, Jimenez Castro PD, Borrás P, Arumugam S, Penzhorn BL, Ybañez AP, Irwin P, Traub RJ. 2023. Heartworm adulticide treatment: a tropical perspective. Parasit Vector 16:148.

Veterinary Parasitology: parasite identification, diagnostic methods, and education.

PhD (Cornell University)

Dr. Lucio-Forster earned her PhD in Microbiology from Cornell University in 2007 where she studied zoonotic waterborne and soil-transmitted parasites under the tutelage of Dr. Dwight D. Bowman. After graduation, she accepted a position in Cornell’s Department of Microbiology and Immunology, where her main focus is teaching Clinical Diagnostic Parasitology to 3rd and 4th year veterinary students. Additionally, she is a co-instructor in the courses Wildlife Parasitology and Parasites as Literary Protagonists, and an invited lecturer in General, Medical and Veterinary Parasitology, Swine Management, and Sheep and Goat Medicine Lab courses. Dr. Lucio-Forster has authored a number of manuscripts on parasite detection and identification, and is currently working on chapters for the new editions of Infectious Disease Management in Animal Shelters and Infectious Diseases of the Dog and Cat. 

Dr. Carlin is a veterinarian specializing in the epidemiology of zoonotic pathogens and emerging infectious disease. She studies incidence and transmission dynamics of zoonotic pathogens, focusing on the interfaces among people, animals, and the environments in which they live. She has studied infectious disease dynamics in the United States, Liberia, Guinea, Kenya, and Tanzania. She also specializes in biodefense policy with a focus on working to develop and advocate for policy-driven opportunities to prevent high-consequence outbreaks.

BS (College of Mount Saint Vincent), DVM (Cornell University)

Dr. Carlin has been consulting since 2011 and launched Parapet Science & Policy Consulting in 2023. She previously served as Assistant Research Professor at Georgetown University and as Senior Health and Policy Specialist at EcoHealth Alliance. In 2013, she completed a fellowship with the U.S. Food and Drug Administration Center for Veterinary Medicine on data analysis and other aspects of antimicrobial resistance. Prior to that, she was Senior Professional Staff with the U.S. House of Representatives Committee on Homeland Security, where for more than five years she handled medical preparedness, biodefense, and science and technology policy. That position began as an American Veterinary Medical Association/American Association for the Advancement of Science fellowship.

Ellen CARLIN | Owner | Research profile (researchgate.net)

Dr. Epe’s specialties include: Drug discovery, Helminths of dogs & cats, Control of parasitic diseases of livestock and companion animals, and Establishing a QM system in routine diagnostic parasitology with accreditation.

Hannover School of Veterinary Medicine (DVM)

Dr. Epe got his degree in Veterinary Medicine at the Hannover School of Veterinary Medicine, Germany, in 1990. After a post-doctoral position there, he spent 15 years in academia in a tenured position, heading the Diagnostic Labs and Services Unit with full responsibilities in teaching, state examination, and supervision of doctoral students. He has extensive experience in diagnosis, epidemiology, and control of parasite infections. Research activities included molecular parasitology, and working with nematodes and arthropods of companion animals.

In 2003, Dr. Epe became a Diplomat of the European Veterinary Parasitology College (DipEVPC) and was twice re-accredited since then.

In 2007, Dr. Epe transitioned to a commercial research position at Novartis Animal Health, Switzerland, gaining experience in drug profiling, a broader knowledge of parasite models, and a general business acumen of the animal health industry. The period of 2011-2014 saw him taking on the role of Lead Finder in the Human Health Research headquarters of Novartis in Boston, USA, to identify projects for the animal health pipeline, more drug development technologies, and facilitate cross-divisional communication. Returning to Novartis Animal Health Switzerland in 2014 as Head of Parasiticide Research, Dr. Epe managed a research pipeline in Parasitology and a large research team and corresponding budget; his major focus was building, communicating, and implementing a research strategy for Veterinary Parasitology.

Christian EPE | Head Parasitology Research | Dr. med. vet., DipEVPC | Boehringer Ingelheim, Ingelheim am Rhein | BIRIT | Research profile (researchgate.net)

Dr. Getchell has a broad background in fish health medicine, with specific training and expertise in conducting experimental trials with a variety of fish species.  He has focused on research in emerging pathogens of fish, including rhabdoviruses, which are the focus of the two most recent projects.  As PI or co-Investigator on several Sea Grant and USDA-NIFA funded grants, he has administered projects (e.g. staffing, sample collections, budget), collaborated with other researchers, and produced several peer-reviewed publications from each project. 

Collaborations. In 2017 he worked with Jose Andrés and Steve Bogdanowicz tracking the source of a VHSV IVb outbreak in Round Gobies that occurred in Cayuga Lake near King Ferry. With further help from the AQUAVET® Summer Fellow, Erika First (DVM Class of 2019) we sequenced whole genomes of the aquatic rhabdovirus of eleven VHSV isolates and explored their genetic variation to determine where the VHSV outbreak on the eastern shore of Cayuga Lake originated. The phylogenetic tree created from these aligned sequences and four other complete VHSV IVb genomes shows the Cayuga Lake isolates are closely related to the Lake Erie isolates.

Dr. Getchell continues to collaborate with Dr. Jim Casey and Dr. Donna Cassidy-Hanley on their USDA Hatch grant that is bringing an eDNA curriculum to New York schools.  Our interests in this project are to continue to bring down the costs of DNA extractions and assist with quantitative PCR assay development.  The project concentrates on invasive species detection.  The same technology also can be used to search for emerging fish pathogens, which explains a long-term interest in this extension/teaching effort.

Mentoring. Dr. Getchell informally mentors many students in the Aquatic Animal Health Program.  His most recent undergraduate student in the lab will be an author on the next VHSV sequencing manuscript.  He is mentoring several of the recent AQUAVET^® alumni, including Kwamina Otseidu (class of 2021), who, along with Gabby Mentis (DVM Class of 2019) and Timi Wu (DVM 2017), has assisted him in developing a digital fish pathology collection.  

Diagnostic Investigations. Our laboratory operates the Fish Disease Diagnostic Laboratory, a service laboratory providing disease diagnostic assistance to the aquaculture community, research community, and fish hobbyist in New York State. We also assist the New York State Department of Environmental Conservation in investigations of fish kills in wild fish populations in the state. Many times these diagnostic investigations lead to more in-depth research investigations in fish health issues. Our diagnostic efforts have led to a major effort to understand the implications of the emergence of Viral Hemorrhagic Septicemia Virus Genotype IVb (VHSV IVb) in a variety of fish in the Great Lakes Basin.  This effort has been undertaken in collaboration with the Laboratory of Dr. James Casey as well as a number of collaborators including the USDA APHIS,  the USGS Western Fisheries Research Center, Seattle, WA, the New York State Department of Environmental Conservation and the Department of Natural Resources in the College of Agriculture and Life Sciences at Cornell. 

PhD (Cornell University)
MS (Oregon State University
BA (University of New Hampshire)

Dr. Getchell has been associated with the department since 1995 (previously he was an Extension Associate and Research Support Specialist in the Department of Avian and Aquatic Animal Medicine, (1990-1995). He served as a marine pathologist with the Maine Department of Marine Resources (1985-1990) after graduating with an M.S. from Oregon State University focusing on diseases of salmonids. He has obtained funding (FDA, USDA, NY Sea Grant, etc.) to study emerging diseases of fish, molecular diagnostic methods, and target animal safety studies.

He received his postdoctoral training in the laboratory of Dr. Paul Bowser.

Journal of Aquatic Animal Health Best Paper Award 2011

Past President of the American Fisheries Society Fish Health Section
Associate Director of AQUAVET®
AVMA Aquatic Veterinary Medical Committee

• Field investigation of common diseases of poultry including avian influenza (AI), Newcastle disease virus (NDV), Mycoplasma gallisepticum (MG), infectious bronchitis (IBV) and infectious bursal disease(IBD)
• Epidemiology and pathology of poultry diseases in the tropics

• BSc. – 1985 Colorado State University, Bachelor of Science – Biological Sciences
• DVM – 1990 Cornell University College of Veterinary Medicine – Doctor of Veterinary Medicine
• Residency – 1993-1995 University of Pennsylvania – Certificate of Residency in Avian Medicine and Pathology

• 2011 – Present Senior Extension Associate, Poultry Extension at the Animal Health Diagnostic Lab (AHDC), College of Veterinary Medicine, Cornell University
  As part of the Veterinary Services Unit of the AHDC, responsibilities include translating and interpreting poultry test data for veterinary practitioners and poultry producers, providing technical assistance for commercial poultry producers and backyard flock owners and collaborating with program coordinators in the New York State Department of Agriculture and Markets. Additionally, assist Cornell Cooperative Extension county coordinators in their poultry production and poultry processing activities.
• 2007-2010 Senior Veterinary Advisor, Development Alternatives Inc. (DAI) USAID-funded STOP Avian Influenza Project, Bethesda, MD
  Provide assistance and technical oversight on global STOP AI programs in Southeast Asia, Central Asia and Africa. Assist in developing strategies and programs for national and local pandemic preparedness plans.
• 2006-2007 Veterinary Diagnostician/International Consultant, Avian Influenza Response Unit, Food and Agricultural Organization of the United Nations, Rome, Italy
  Part of response unit traveling to countries with Highly Pathogenic Avian Influenza (HPAI) outbreaks to provide technical advice and assistance in enhancing laboratory capacity. Assessed emergency preparedness plans of countries for the control and eradication of HPAI.
• 1999-2006 Manager of Technical Services, ISA Poultry Genetics, Ithaca, NY
  Design health programs, monitor breeder health and supervise veterinary and laboratory personnel, two diagnostic laboratories and quality assurance at two hatcheries.
• 1995-1999 Extension Associate, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University
  Manage avian diagnostic laboratory, perform necropsies and diagnostic histopathology for avian submissions, perform diagnostic serology and virus isolation of avian pathogens such as NDV, IBV and AI.
• 1993-1995 Resident in Avian Medicine and Pathology, Poultry Diagnostic Laboratory, New Bolton Center, University of Pennsylvania
  Coordinate large caseloads of poultry submissions from Pennsylvania’s commercial poultry industry. Perform necropsies and histopathological examination of avian cases. Resource person for Pennsylvania Department of Agriculture and instructor for poultry disease courses designed for second and third year veterinary students.
• 1990-1993 Senior Veterinary and Project Officer, Department of Livestock Services, Ministry of Agriculture, Gambia, West Africa
  Supervise veterinary clinic, co-direct Pan-African Rinderpest Campaign and acted as National Coordinator for the United Nations Women In Development (WID) project.

1. Mullins, G., Jagne, J., Stone, L., Konings, E., Howard-Grabman, L., Hartman, F., Fulton, M. (2010) ‘One World One Health’ in practice: Integrating public health and veterinary curricula on emerging infectious diseases in Africa. Int. J Infect Dis. Vol 14, pp e377-e378
2. Cardona, C., Lucio, B., O’ Connell, P., Jagne, J., Schat, K.A. (2000) Humoral immune responses to chicken infectious anemia virus in three strains of chickens in a closed flock. Avian Diseases, 44 (3): 661-667
3. Jagne, J., Aini, I., Schat, K.A., Fennell, A. and Touray, O. (1991). Vaccination of village chickens in the Gambia against Newcastle disease using the heat-resistant, food-pelleted V4 vaccine. Avian Pathology, 20: 721-72
4. Shaver Poultry Newsletter summer 2004 “Avian Influenza” –J. Jagne
5. ISA Babcock newsletter, winter 2002 “Infectious Bronchitis in Layers” - J.Jagne

Product development, professional services and regulatory affairs. He works directly with the FDA to gain approval for new products.

DVM (Ohio State University)

Dr. Lynn completed graduate training in Veterinary Physiology and Pharmacology and graduated from the College of Veterinary Medicine at the Ohio State University in 1983. After two years of full time veterinary practice in Greensboro, North Carolina he worked at Schering Animal Health for one year. In 1986 Dr. Lynn moved to Novartis Corporation (now part of Elanco) where he spent 11 years working in product development, professional services and finally in the regulatory affairs department working directly with the FDA to gain approval for new products. His efforts helped produce several new product approvals including Interceptor™, Sentinel™ and Percorten-V®.

Dr. Lynn is the author or co-author of several veterinary textbooks and numerous research articles.

My research interests and approaches are at the interface between the agent and the host in the relevant environment at the local and global levels. Examples include the followings:
Epidemiology and risk assessment of zoonotic vectorborne diseases with emphasis on food- and waterborne and arthropod-borne diseases in different food matrices and among different hosts and at the local and global levels. Of particular interest are foodborne bacterial (including Campylobacter spp., E. coli, Listeria moncytogenes, and Salmonella spp.) and protozoal (Cryptosporidium spp. and Giardia sp.) infections. Among the arthropod-borne diseases, West Nile Virus and Rift Valley fever are of particular interest.
The application of epidemiologic techniques to ecohealth approaches to understand the mechanism of emergence, introduction, transmission and perpetuation of infectious zoonotic diseases in different populations and to evaluate the cost effective intervention strategies to mitigate associated risk.
Epidemiology of neurologic disorders including equine motor neuron disease as a possible model for the human amyotrophic lateral sclerosis its application in translation research.

• BVSc - 1975 Faculty of Veterinary Medicine, Univ. of Khartoum MVSc
• 1979 Faculty of Veterinary Medicine, Univ. of Khartoum
• DPVM - 1980 Royal Agri. & Vet. College, Univ. of Copenhagen
• MPVM - 1984 School of Veterinary Medicine, Univ. of Calif., Davis
• PhD - 1986 School of Veterinary Medicine, Univ. of Calif., Davis

• Africa:  Ethiopia, Kenya, Nigeria, Sudan, Tanzania, Tunisia
• Asia: China, Laos, Malaysia, Tajikistan, Thailand, Vietnam
• Middle East:  Jordan, Qatar, Saudi Arabia, Syria
• South America: Brazil

• Mohammed HO, Atwill E, Dunbar L, Ward T, McDonough P, Gonzalez R, Stipetic K. 2010. The risk of Listeria monocytogenes infection in beef cattle operations. J Appl Microbiol. 108:349-356.
• Kraus MS, Jesty SA, Gelzer AR, Ducharme NG, Mohammed HO, Mitchell LM, Soderholm LV, Divers TJ. 2010. Measurement of plasma cardiac troponin I concentration by use of a point-of-care analyzer in clinically normal horses and horses with experimentally induced cardiac disease. Am J Vet Res. 7:55-59.
• Cheetham J, Riordan AS, Mohammed HO, McIlwraith CW, Fortier LA. 2010. Relationships between race earnings and horse age, sex, gait, track surface and number of race starts for Thoroughbred and Standardbred racehorses in North America. Equine Vet J. 42(4):346-350.
• Grenager NS, Divers TJ, Mohammed HO, Johnson AL, Albright J, Reuss MS. 2010. Epidemiological features and association with crib-biting in horses with neurological disease associated with temporohyoid osteoarthropathy (1991–2008). Equine Vet. Edu. 22:467-472.
• Szonyi B, Bordonaro R, Wade SE, Mohammed HO. 2010. Seasonal variation in the prevalence and molecular epidemiology of Cryptosporidium infection in dairy cattle in the New York City Watershed. Parasitol Res. 107(2):317-25.
• Szonyi B, Wade SE, Mohammed HO. 2010. Temporal and spatial dynamics of Cryptosporidium parvum infection on dairy farms in the New York City Watershed: a cluster analysis based on crude and Bayesian risk estimates. Int J Health Geogr. 9:31.
• Mark-Carew MP, Khan Y, Wade SE, Schaaf S, Mohammed HO. 2010. Incidence of and risks associated with Giardia infections in herds on dairy farms in the New York City Watershed. Acta Vet Scand. 52:44.
• Decarlo CH, Clark AB, McGowan KJ, Ziegler PE, Glaser AL, Szonyi B, Mohammed HO. 2011. Factors Associated With the Risk of West Nile Virus Among Crows in New York State. Zoonosis Public Health. 58(4):270-275.
• McComb T, Bischoff K, Thompson B, Smith MC, Mohammed HO, Ebel J, Hillebrandt J. 2010. An investigation of blood selenium concentrations of goats in New York State. J Vet Diagn Invest. 22(5):696-701.
• Nixon AJ, Begum L, Mohammed HO, Huibregtse B, O'Callaghan MM, Matthews GL. 2011. Autologous chondrocyte implantation drives early chondrogenesis and organized repair in extensive full- and partial-thickness cartilage defects in an equine model. J Orthop Res. 29(7):1121-1130.
• Schaefer JJ, White HA, Schaaf SL, Mohammed HO, Wade SE. 2011. Modification of a commercial Toxoplasma gondii immunoglobulin G enzyme-linked immunosorbent assay for use in multiple animal species. J Vet Diagn Invest. 23(2):297-301.
• Sparks HD, Nixon AJ, Fortier LA, Mohammed HO. 2011. Arthroscopic reattachment of osteochondritis dissecans cartilage flaps of the femoropatellar joint: long-term results. Equine Vet J. 43(6):350-359.
• Watts AE, Nixon AJ, Yeager AE, Mohammed HO. 2011. A collagenase gel/physical defect model for controlled induction of superficial digital flexor tendonitis. Equine Vet J. (Epub ahead of print).
• Mark-Carew MP, Wade SE, Chang YF, Schaaf S, Mohammed HO. 2011. Prevalence of Giardia duodenalis assemblages among dairy herds in the New York City Watershed. Vet Parasitol. 185(2-4):151-157.
• Montgomery KW, Ledbetter EC, Mohammed HO. 2011. Effect of short-term diphenhydramine administration on aqueous tear production in normal dogs. Vet Ophthalmol. 14:395-399.
• Ortved KF, Nixon AJ, Mohammed HO, Fortier LA. 2011. Treatment of subchondral cystic lesions of the medial femoral condyle of mature horses with growth factor enhanced chondrocyte grafts: A retrospective study of 49 cases. Equine Vet J. (Epub ahead of print). PMID: 22128804.
• Syzoni B, Chang YF, Wade S, Mohammed HO. 2012. Evaluation of factors associated with the risk of Cryptosporidium parvum in dairy cattle. Am J Vet Res. 73(1):76-85.
• Schaefer JJ, White HA, Schaaf SL, Mohammed HO, Wade SE. 2012. Chimeric protein A/G conjugate for detection of anti-Toxoplasma gondii immunoglobulin G in multiple animal species. J Vet Diagn Invest. 24(3):572-575.
• Radcliffe RM, Divers TJ, Fletcher DJ, Mohammed H, Kraus MS. Evaluation of L-lactate and cardiac troponin I in horses undergoing emergency abdominal surgery. J Vet Emerg Crit Care (San Antonio).;22(3):313-319.

My research interests are at the intersection of production animal agriculture and public health at the population level - with an emphasis on dairy cattle. On-going projects are in the areas of transition cow health and performance, calf infectious diseases (especially zoonoses), and milk quality. I teach a variety of bovine herd health and epidemiology classes as well as provide consulting and clinical service for the dairy industry.

• B.S. - 1993 BioChemistry (Cum Laude) - University of New York at Geneseo
• DVM - 1997 College of Veterinary Medicine, Cornell University
• Ph.D.. - 2002 Epidemiology - Comparative Biomedical Sciences Graduate School, Cornell University

• 1997- 1998 Associate Large Animal Veterinarian - Granville Veterinary Service, Granville, NY
• 1997- 2004 Relief Veterinarian - C.W. Nydam Veterinary Clinic, P.C., Stamford, NY
• 1998 - 2001 Veterinary Research Assistant - Section of Epidemiology, Dept. of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY
• 2001 - 2006 Senior Extension Veterinarian - New York State Animal Health Diagnostic Center, Cornell University, Ithaca, NY
• 2007 - 2012 Assistant Professor of Dairy Health and Production
• 2013 – present Director, Quality Milk Production Services; Animal Health Diagnostic Center
• 2018 – present Professor of Dairy Health and Production; Dept. of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University

1. Nydam DV, Wade SE, Schaaf SL, Mohammed HO.  Number of Cryptosporidium parvum oocysts and Giardia spp. cysts shed by dairy calves after natural infection.  Am J Vet Res 2001; Oct; 62 (10):1612-1615

2. Perkins GA, Yeager A, Erb HN, Nydam DV, Divers TJ, Bowman JL. Survival of foals with experimentally induced Rhodococcus equi infection given hyperimmune plasma containing Rhodococcus equi antibody or normal equine plasma. Vet Therapeutics. 2002; Vol 3, No 3 Fall: 334-346

3. Warnick LD, Nydam DV, Maciel A, Guard CL, Wade SE. Udder cleft dermatitis and Sarcoptic mange in a dairy herd. J Am Vet Med Assoc 2002; Jul 15; 221(2): 273-279

4. Perkins G, Lamb S, Erb HN, Schanbacher B, Nydam DV, Divers TJ. Plasma adrenocorticotropin (ACTH) concentration and clinical response in horses treated for Cushing’s Disease with cyproheptadine and pergolide. Equine Vet J 2002; 34 (7) 679-685

5. Nydam DV, Lindergard GL, Guard CL, Schaaf SL, Wade SE, Mohammed HO.  Serological detection of exposure to Cryptosporidium parvum in cattle by ELISA and evaluation in relation to coprological tests.  Parasitol Res. 2002; Sep; 88(9): 797-803

6. *Wakshlag JJ, Barr SC, Ordway GA, Kalfelz FA, Flaherty CE, Cristensen BW, Sheppard LA, Nydam DV, Davenport GM. Effect of dietary protein on lean body wasting in dogs: correlation between loss of lean mass and markers of proteasome-dependent proteolysis. J Anim Physiol a Anim Nutr. 2003; 87:408-420.

7. *Lindergard G, Nydam DV, Wade SE, Schaff SL, Mohammed HO. A novel multiplex polymerase chain reaction approach for detection of four human infective Cryptosporidium isolates: Cryptosporidium parvum, types H and C, Cryptosporidium canis, and Cryptosporidium felis in fecal and soil samples. J Vet Diag Invest 2003; 15: 262-267

8. Perkins G, Nydam DV, Flaminio J., Ainsworth DM. Serum IgM concentrations in normal fit horses and in horses with lymphoma or other medical conditions. J Vet Intern Med. 2003; 17(3):337-342.

9. *Lindergard G, Nydam DV, Wade SE, Schaaf SL, Mohammed HO. The sensitivity of PCR detection of Cryptosporidium oocysts in fecal samples using two DNA extraction methods. Mol Diagn. 2003;7(3):147-53

10. *Wakshlag JJ, Cooper RR, Wakshlag RR, Kallfelz FA, Barr SC, Nydam DV, Dimauro S. Biochemical evaluation of mitochondrial respiratory chain enzymes in canine skeletal muscle. Am J Vet Res 2004; 65 (4): 480 - 484

11. *Schatzberg SJ, Cutter-Schatzberg K, Nydam DV, Barrett J, Penn R, Flanders J, deLahunta A, Lin L, Mignot E. Case study: The effect of hypocretin replacement therapy in a 3 year old Weimaraner with narcolepsy. J Vet Intern Med 2004; 18(4):586-8. 

12. *Gardner CE, Nydam DV, Ellis RG, Kelsey S, McDonough PL, Warnick LD. Management of an outbreak of salmonellosis on a commercial calf raising unit. Bov Pract 2004; Vol 38, No. 2: 147-154.

13. Gelzer ARM, Attmann T, Radicke D, Nydam DV, Candinas R, Barton M, Lutter G, Effects of Acute Systemic Endothelin Receptor Blockade on Cardiac Electrophysiology in Vivo. J Cardiovasc Pharmacol. 2004; Nov;44(5):564-570.

14. *Mitchell HM, Nydam DV, Reyher KK, Gilbert RO. The Opportunities Map at Cornell University: Finding Direction in Dairy Production Medicine. J Vet Med Educ. 2004; Winter;31(4):381-4

15. Nydam DV, Lindergard GL, Santucci F, Schaff SL, Wade SE, Mohammed HO. Risk of Cryptosporidium parvum and Cryptosporidium hominis in dairy cattle in a New York watershed. Am J Vet Res 2005; 66 No. 3, 413-417.

16. Stokol T and Nydam DV. Effect of anticoagulant, storage temperature, and duration of storage on non-esterified fatty acid and B-hydroxybutyrate concentrations from dairy cattle. J Dairy Sci 2005; 88 (9): 3139-44.

17. *Trotz-Williams LA, Martin SW, Martin D, Duffield T, Leslie KE, Nydam DV, Peregrine AS. Multiattribute evaluation of two simple tests for the detection of Cryptosporidium parvum oocysts in calf faeces. Vet Parasit 2005; 134: 15-23

18. Nydam DV and Mohammed HO. Quantitative risk assessment of Cryptosporidium spp. infection in calves on dairy farms. J Dairy Sci 2005; 88(9): 3932-3943

 19. *Gardner RB, Nydam DV, Mohammed HO, Ducharme NG, Divers TJ. Elevations in Serum Gamma Glutamyl Transferase Values in Horses with Right Dorsal Displacements of the Large Colon. J Vet Intern Med 2005; 19(5):761-764

20. Flaminio MJBF, Nydam DV, Sebastian M, Bernard WV, Hillegas JM, Matychak MB. The Mare Reproductive Loss Syndrome (MRLS) and the Eastern Tent Caterpillar: Immunological Testing of Aborting Mares. Intern J App Res Vet Med  2005; Vol 3 No. 3: 207-216

21. *Trotz-Williams LA, Martin DS, Gatei W, Cama V, Peregrine AS, Martin SW, Nydam DV, Jamieson F, Xiao L. Genotype and subtype analyses of Cryptosporidium isolates from dairy calves and humans in southern Ontario. Parasit Res 2006 Sep;99(4):346-52

22. *Bicalho RC, Cheong SH, Warnick LD, Nydam DV, Guard CL.  The effect of digit amputation or arthrodesis surgery on culling and milk production in Holstein dairy cows. J Dairy Sci 2006; Jul;89(7):2596-602

23. *Figueiredo MD, Nydam DV, Perkins GA, Mitchell HM, Divers TJ. Prognostic value of blood lactate concentration measured cow-side using a portable clinical analyzer in Holstein dairy cattle with abomasal disorders. J Vet Intern Med 2006; 20: 1463-1470

24. Stokol T and Nydam DV. Effect of hemolysis on non-esterified fatty acid and B-hydroxybutyrate concentrations in bovine blood. J Vet Diagn Invest 2006; Sep; 18: 466-469

25. *Wilke MM, Nydam DV, Nixon AJ. Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model. J Ortho Res. 2007 Jul; 25(7):913-925

26. Flaminio MJ, Borges AS, Nydam DV, Hecker R, Horohov DW, Matychak MB. The effect of CpG-ODN on antigen presenting cells of the foal. J Immun Based Therapies Vac. 2007; Jan 25;5(1):1

27. *Ziegler PA, Santucci F, Lindergard G, Nydam DV, Wade SE, Schaaf S, Chang YF, Mohammed HO.  Evaluation of Polymerase chain reaction diagnosis of  Cryptosporidium spp. in Dairy Cattle and Wildlife. Vet Ther. 2007 Summer;8(2):148-59

28. *Trotz-Williams LA, Martin SW, Leslie KE, Duffield T, Nydam DV, Peregrine AS. Calf-level risk factors for neonatal diarrhea and shedding of Cryptosporidium parvum in Ontario dairy calves: Prev Vet Med. June 2007; 82: 12-28

29. *Gardner RB, Nydam DV, Juna JA, Bicalho M, Matychak MB, Flaminio MJ. Serum opsonization capacity, phagocytosis and oxidative burst activity in neonatal foals in the intensive care unit. J Vet Intern Med. 2007; July/August, 21: 797-805

30. *Trotz-Williams LA, Martin SW, Leslie KE, Duffield T, Nydam DV, Peregrine AS. Association between management practices and within-herd prevalence of Cryptosporidium parvum shedding on dairy farms in southern Ontario. Prev Vet Med. Jan 2008; 83: 11-23

31. *Lanzas C, Warnick LD, Ivanek R, Ayscue P, Nydam DV, Gröhn YT. The risk and control of Salmonella outbreaks in calf-raising operations: a mathematical modeling approach. Vet Res. 2008; 39(6):61

32. Flaminio MJBF, Nydam DV, Marquis H, Matychak MB, Giguère S. Foal monocyte-derived dendritic cells become activated upon Rhodococcus equi infection. Clin Vaccine Immunol. 2009 Feb 16(2): 176-83

33. Nydam CW, Nydam DV, Guard CL, Gilbert RO. The Summer Dairy Institute model: Teaching dairy production medicine to entry-level veterinarians. J Vet Med Educ. 2009 Spring; 36(1):16-21

34. Mohammed HO, Stipetic K, McDonough PL, Gonzalez RN, Nydam DV, Atwill ER. Identification of potential on-farm sources of Listeria monocytogenes in herds of dairy cattle. Am J Vet Res. 2009 Mar;70(3): 383-8

35. *Burton AJ, Nydam DV, Olivett TL, Divers TJ. Prognostic Indicators for Survival of downer cows managed with a flotation tank system in a referral hospital. J Am Vet Med Assoc. 2009 May 1;234(9):1177-82

36. *Linden TC, Nydam DV, Bicalho RC. Calf birth weight and its association with calf and cow survivability, disease incidence, reproductive performance, and milk production. J Dairy Sci. 2009 Jun;92(6):2580-8

37. *Ollivett TL, Nydam DV, Bowman DD, Zambriski JA, Bellosa ML, Linden TC, Divers TJ. Effect of nitazoxanide on cryptosporidiosis in experimentally infected neonatal dairy calves. J Dairy Sci. 2009; 92, 1643-1648

38. *Cummings KJ, Warnick LD, Cripps CJ, Gröhn YT, McDonough PL, Nydam DV, Alexander KA, Reed KE. The Incidence of Salmonellosis among Dairy Herds in the Northeastern United States. J Dairy Sci. 2009 Aug;92(8):3766-74

39. Morkel P, Radcliffe RW, Jago M, DuPreez P, Flaminio MJBF, Nydam DV, Taft A, Lain D, Miller MM, Gleed RD. Acid-Base balance and ventilation during sterna and lateral recumbency in field immobilized black rhinoceros (Diceros bicornis bicornis) receiving oxygen insufflations. J Wildl Dis. 2010 Jan;46(1):236-45

40. *Ospina PA, Nydam DV, Stokol T, Overton TR. Evaluation of NEFA and β-hydroxybutyrate (BHB) in transition dairy cattle in the Northeast USA. Critical thresholds for prediction of clinical diseases. J Dairy Sci. 2010, 93: 546-554

++ Awarded the most cited manuscript in the Journal of Dairy Science 2010-2014 by the American Dairy Science Association

41. *Burton AJ, Nydam DV, Long ED, Divers TJ. Clinical and pathological findings associated with bovine lymphosarcoma: A retrospective study of 112 cases.  J Vet Intern Med. 2010, 24(4), 960-964

42. *Ospina PA, Nydam DV, Stokol T, Overton TR. Associations of elevated NEFA and β-hydroxybutyrate concentrations with early lactation reproductive performance and milk production  in transition dairy cattle in the Northeast United States. J Dairy Sci. 2010, 93: 1596-1603

43. *Leone WM, Nydam DV, Welcome F, Warnick LD. Effects of removing cows from chronic oxytocin use during lactation. Bov Pract. 2010, 44(1) 83-87

44. *Ospina PA, Nydam DV, Stokol T, Overton TR. Association between the proportion of sampled transition cows with elevated NEFA and β-hydroxybutyrate (BHBA) and disease incidence, pregnancy rate, and milk production at the herd-level. J Dairy Sci. 2010, 93: 3595-3601

45. *Burton AJ, Nydam DV, Dearen TK, Mitchell K, Bowman DD and Xiao L.  The prevalence of Cryptosporidium and identification of the Cryptosporidium horse genotype from foals in New York State. Vet Parasit. 2010 Nov 24;174(1-2):139-44

46. Kornreich B, Enyeart M, Jesty S, Nydam DV, Divers TJ. The effects of pentoxifylline on equine platelet aggregation. J Vet Intern Med. 2010, 25(5):1196-202

47. *Burton AJ, Nydam DV, Jones G, Zambriski JA, Linden TC, Cox G, Davis R, Brown A, Bowman DD. Antibody responses to a Cryptosporidium parvum rCP15/60 vaccine. Vet Parasit. 2011 Jan 10;175(1-2):178-81

48. *Bellosa ML, Nydam DV, Liotta JL, Zambriski JA, Linden TC, Bowman DD. A Comparison of Fecal Percent Dry Matter and Number of Cryptosporidium parvum Oocysts Shed to Observational Fecal Consistency Scoring in Dairy Calves. J Parasitol. 2011 97(2): 349-351

49. *Cheong SH, Nydam DV, Crosier BM, Galvao KN, Gilbert RO. Cow and herd level risk factors for subclinical endometritis in lactating Holstein cows. J Dairy Sci. 2011, 94: 762-770

50. *Galvão KN‍‍, Pighetti GM, Cheong SH, Nydam DV, Gilbert RO. Association between interleukin-8 receptor (CXCR1) polymorphism and disease incidence, production, reproduction, and survival in Holstein cows. J Dairy Sci. 2011 94(4):2083-2091

51. *Dawson DR, Nydam DV, Price CT, Graham JE, Cynamon MH, Divers TJ, Felippe MJ. Effects of opsonization of Rhodococcus equi on bacterial viability and phagocyte activation. Am J Vet Res 2011 Vol 72: 1465-1475

52. *Soberon F, Ryan CM, Nydam DV, Galton DM, Overton TR. The Effects of Increased Milking Frequency during Early Lactation on Milk Yield and Milk Composition on Commercial Dairy Farms. J Dairy Sci. 2011, 94:4398-4405

53. *McArt JAA, Nydam DV, Ospina PA, Oetzel GR. A field trial on the effect of propylene glycol on milk yield and resolution of ketosis in fresh cows diagnosed with subclinical ketosis. J Dairy Sci. 2011, 94: 6011-6020

54. *Huzzey JM, Nydam DV, Grant RJ, Overton TR. Associations between prepartum cortisol, haptoglobin, and non-esterified fatty acids and postpartum health status. J Dairy Sci. 2011, 94: 5878-5889

55. Bicalho MLS, Santos TMA, Nydam DV, Machado VS, RC Bicalho.  Evaluation of bacteriophages oral administration in neonatal calves: phage survivability, impact on fecal Escherichia coli and calf health. Livestock Sci. 2011, 144(3): 294-299

56. Kornreich BG, Craven M, McDonough SP, Nydam DV, Simpson KW. Fluorescent in situ hybridization for the identification of bacterial species in archival heart valve sections of canine bacterial endocarditis. J Comp Path. 2012, 146(4):298-307

57. *Cheong SH, Nydam DV, Galvao KN, Crosier BM, Ricci A, Caixeta L, Fraga M, Gilbert RO. Use of urinary reagent test strips for diagnosis of endometritis in dairy cows. Therio. 2012, 77(5):858-64

58. Morkel P, Miller MM, Jago M, Radcliffe RW, duPrez P, Olea-Popelka F, Nydam DV, Taft A, Gleed RD. Serial Temperature Monitoring and Comparison of Rectal and Muscle Temperatures in Immobilized Free-Ranging Black Rhinoceros (Diceros bicornis). J Zoo Wild Med. 2012, 43(1): 120-124

59. *Ness SAL, Bain FT, Zantingh AJ, Gaughan EM, Story MR, Divers TJ, Nydam DV. Ultrasonographic visualization of colonic mesenteric vasculature as an indicator of large colon right dorsal displacement and/or 180 degree volvulus in horses. Can Vet J. 2012, 53: 378-382

60. *Burton AJ, Nydam DV, Mitchell K, Bowman DD. The prevalence of Cryptosporidium shedding in alpaca crias and their dams in the Northeastern USA. J Am Vet Med Assoc. 2012, 241(4):496-8

61. *Ollivett TL, Nydam DV, Linden TC, Bowman DD, Van Amburgh MA. Effect of nutritional plane on health and performance in dairy calves after experimental infection with Cryptosporidium parvum.  J Am Vet Med Assoc. 2012, 241(11):1514-1520

++ Awarded in Top 10 papers of 2012 in food animal medicine by the American College of Veterinary Internal Medicine

62. *Cheong SH, Nydam DV, Galvao KN, Crosier BM, Gilbert RO. Effects of diagnostic low-volume uterine lavage shortly before first service on reproductive performance, culling, and milk production in dairy cows. Therio. 2012, 77(6): 1217-22

63. *Ospina PA, Nydam DV, DiCiccio TJ. The risk ratio, an alternative method to the odds ratio for estimating the association between multiple risk factors and a dichotomous outcome.  J Dairy Sci. 2012, 95: 2576-2584

64. *McArt JAA, Nydam DV, Oetzel GR. A field trial on the effect of propylene glycol on displaced abomasum, removal from herd, and reproduction in fresh cows diagnosed with subclinical ketosis. J Dairy Sci. 2012, 95: 2505-2512

65. Miller MM, Jago M, Radcliffe RW, Morkel P, Olea-Popelka F, Sefton J,  duPrez P, Taft A, Nydam DV, Gleed RD. Capture related hypoglycemia and recovery in free-ranging Black Rhinoceros (Diceros bicornis). J Wildl Dis. 2012, Jul;48(3):840-2

66. *McArt JAA, Nydam DV, Oetzel GR. Epidemiology of subclinical ketosis in early lactation dairy cattle. J Dairy Sci. 2012, 95: 5056-5066

++ Awarded among the most cited manuscripts in the Journal of Dairy Science 2012-2015 by the American Dairy Science Association

67. *Warren AL, Stokol T, Hecker KG, Nydam DV. Storage-associated changes in the bovine hemogram with the ADVIA 120 hematology analyzer. Comp Clin Path. 2013, 22: 1235-1240

68.*Huzzey JM, Nydam DV, Grant RJ, Overton TR. The effects of overstocking Holstein dairy cattle during the dry period on cortisol production and energy metabolism. J Dairy Sci. 2012, 95: 4421-4433

69. *Zambriski JA, Maves RC, Nydam DV, Ayvar V, Cepeda D, Castillo R, Diaz-Pino A, Saito M, Gilman RH. Effect of storage temperature and sample volume on Brucella melitensis isolation from goat milk. Intern J Trop Dis and Hygen. 2012, 2(3):207-213

70.*McArt JAA, Nydam DV, Oetzel GR. Dry period and parturient predictors of early lactation hyperketonemia in dairy cattle. J Dairy Sci. 2013, 96: 198-209

71. *Zambriski JA, Nydam DV, Bowman DD, Bellosa ML, Burton AJ, Linden TC, Liotta JL, Ollivett TL, Tondello-Martins L, Mohammed HO. Description of fecal shedding of Cryptosporidium parvum oocysts in experimentally challenged dairy calves. Parasit Res. 2013, Mar; 112(3) 1247-54

72. *Croushore WS, Ospina PA, Welch DC, Zawisza DJ, Nydam DV. The association between β-hydroxybutyrate concentration at diagnosis of left displaced abomasums in dairy cows and removal from the herd post-surgical correction. J Am Vet Med Assoc. 2013, 243(9): 1329-33

73. *Zambriski JA, Nydam DV, Wilcox ZJ, Bowman DD, Mohammed HO, Liotta JL. Cryptosporidium parvum: Determination of ID50 and the dose-response relationship in experimentally challenged dairy calves. Vet Parasit. 2013, 197(1-2):104-12

74. *Teixeira AGV, Bicalho MLS, Machado VS, Oikonomou G, Kacar C, Foditsch C, Young R, Knauer WA, Nydam DV, Bicalho RC. Heat and ultraviolet light treatment of colostrum and hospital milk: Effects on colostrum and hospital milk characteristics and calf health and growth parameters. Vet J. 2013, Aug;197(2):175-81

75. *Ospina PA, McArt JA, Overton TR, Stokol T, Nydam DV. Using non-esterified fatty acids and β-hydroxybutyrate concentrations during the transition period for herd-level monitoring of increased risk of disease and decreased reproductive and milking performance. Vet Clin N Am. 2013, Vol 29: 387-412

76. *McArt JAA, Nydam DV, Oetzel GR, Overton TR, Ospina PA. Elevated non-esterified fatty acids and β-hydroxybutyrate and their association with transition dairy cow performance: A review. Vet J. 2013, 198: 560-570

++ Awarded among the 5 most cited manuscripts in The Veterinary Journal 2014-2015 by Elsevier

77. *Jackson DS, Nydam DV, Altier C. Prevalence and risk factors for brucellosis in domestic yak, Bos grunniens, and their herders in a transumant pastoralist system of Dolpo, Nepal. Prev Vet Med. 2014, 113(1): 47-58

78. *Heins BD, Nydam DV, Woolums AR, Berghaus RD, Overton MW. Comparative efficacy of enrofloxacin and tulathromycin for treatment of pre-weaning respiratory disease in dairy heifers. J Dairy Sci. 2014, 97: 372-382

79. *Radcliffe RW, Morkel P, Jago M, Taft A, duPrez P, Miller MA, Candra D, Nydam DV, Berry JS, Gleed RD. Pulmonary dead space in free-ranging, immoblized black rhinoceroses (Diceros bicornis) in Nambia. J Zoo Wildl Med. 2014, 45(2): 263-271

80. *Yasui T, McCann K, Gilbert RO, Nydam DV, Overton TR. Associations of cytological endometritis with energy metabolism and inflammation during the periparturient period and early lactation in dairy cows. J Dairy Sci. 2014, 97: 2763-2770

81. *Vergara CF, Döpfer D, Cook NB, Nordlund KV, McArt JAA, Nydam DV, Oetzel GR. Risk factors for postpartum problems in dairy cows. J Dairy Sci. 2014, 97: 4127-4140

82. *McArt JAA, Nydam DV, Oetzel GR, Guard CL. Economic analysis of hyperketonemia testing and propylene glycol treatment strategies in early lactation dairy cattle. Prev Vet Med. 2014, Nov 1; 117(1): 170-179

83. *Yasui T, McArt JAA, Ryan CM, Gilbert RO, Nydam DV, Valdez F, Griswold K, Overton TR. Effects of chromium propionate supplementation during the periparturient period and early lactation on metabolism, performance, and cytological endometritis in dairy cows. J Dairy Sci. 2014, 97: 6400-10

84. Werner B, Moroni P, Gioia G, Lavin-Alconero L, Yousaf A, Charter ME, Carter B, Bennett J, Nydam DV, Welcome F, Schukken YH. Genotypic identification of Lactococcus lactis subsp. lactis and association with discrepancies of bacteriological results during intramammary infections on different dairy farms. J Dairy Sci. 2014, 97: 6964-6969

85. Operario DJ, Bristol LS, Liotta J, Nydam DV, Houpt ER.  Correlation between diarrhea severity and oocyst count via quantitative PCR or Fluorescence microscopy in experimental cryptosporidiosis. Am J Trop Med Hyg. 2015, Jan 7;92(1):45-9

86. Fulton RW, d’Offay JM, Eberle R, Moeller RB, Van Campen H, O’Toole D , Chase C, Miller MM, Sprowls R, Nydam DV. Bovine Herpesvirus-1: Evaluation of Genetic Diversity of Subtypes Derived from Field Strains of Varied Clinical Forms and Their Relationship to Vaccine Strains. Vaccine. 2015, Jan 15;33(4):549-58

87. McArt JAA, Nydam DV, Overton MW. Hyperketonemia in early lactation dairy cattle: a deterministic estimate of component and total cost per case. J Dairy Sci. 2015, 98 (3): 2043–2054

88. *Caixeta LS, Ospina PA, Capel MB, Nydam DV. The association of subclinical hypocalcemia, negative energy balance, and disease with body weight change during the first 30 days postpartum in dairy cows milked with automatic milking systems. Vet J. 2015, May; 204 (2):150-6

89. *Mann S, Leal Yepes FA, Overton TR, Wakshlag JJ, Lock AL, Ryan CM, Nydam DV. Dry period plane of energy: effects on feed intake, energy balance, milk production and composition in transition dairy cows. J Dairy Sci. 2015, 98:3366-82

90. *Huzzey JM, Mann S, Nydam DV, Grant RJ, Overton TR. Associations of peripartum analytes of stress, inflammation, and negative energy balance with milk yield and reproductive performance in Holstein dairy cows. Prev Vet Med. 2015, Jul 1;120 (3-4):291-7

91. *Streeter RM, Struble AM, Nydam DV, Bauer J, Castellano M, Todhunter RJ, Cummings B, Wakshlag JJ. The associations between serum adiponectin, leptin, c-reactive protein, and insulin and serum long-chain omega-3 fatty acids in Labrador retrievers. Vet Med: Res Reports. 2015, 6: 103-110

92. *Duplessis M, Mann S, Nydam DV, Girard CL, Pellerin D, Overton TR. Folates and vitamin B12 in colostrum and milk from dairy cows fed different energy levels during the dry period. J Dairy Sci. 2015, 98: 5454-5459

93. Plumed-Ferrer C, Barberio A, Franklin R, Werner B, McDonough P, Bennett J, Gloria G, Rota N, Welcome F, Nydam DV, Moroni P. Antimicrobial susceptibilities and RAPD-PCR fingerprint characterization of Lactococcus lactis subsp. lactis and Lactococcus garvieae isolated from bovine intramammary infection. J Dairy Sci. 2015, 98: 6216–6225

94. *McCarthy MM, Mann S, Nydam DV, Overton TR, McArt JAA. Concentrations of non-esterified fatty acids and β-hydroxybutyrate in dairy cows are not well correlated during the transition period. J Dairy Sci. 2015, 98: 6284–6290

95. *Ollivett TL, Caswell J, Nydam DV, Duffield T, Leslie KE, Hewson J, Kelton D.  Thoracic ultrasonography and bronchoalveolar lavage fluid analysis in Holstein calves affected with subclinical lung lesions.  J Vet Intern Med. 2015 Nov; 29(6):1728-34

96. *Mann S, Leal Yepes FA, Duplessis M, Wakshlag JJ, Overton TR,  Cummings B, Nydam DV. Dry period plane of energy: effects on glucose tolerance in transition dairy cows. J Dairy Sci. 2016, Jan;99(1):701-17

97. *Newman A, Mann S, Nydam DV, Overton TR, Behling-Kelly E. Impact of dietary plane of energy during the dry period on lipoprotein parameters during the transition period in dairy cattle. J An Phys An Nutr. 2016 Feb;100(1):118-26

98. *Mann S, Leal Yepes FA, Overton TR, Lock A, Lamb S, Wakshlag JJ, Nydam DV. Effect of dry period dietary energy level in dairy cattle on volume, concentration of IgG, insulin, and fatty acid composition of colostrum. J Dairy Sci. 2016; 99(2):1515-26

99. *Hernandez D, Nydam DV, Godden SM, Bristol LS, Kryzer A, Ranum J, Schaefer D. Brix refractometry in serum as a measure of failure of passive transfer compared to measured immunoglobulin G and total protein by refractometry in serum from Holstein and Jersey calves.  Vet J. 2016 May;211:82-7

100. *Mann S, Abuelo A, Nydam DV, Leal Yepes FA, Overton TR, Wakshlag JJ. Insulin signaling and skeletal muscle atrophy and autophagy in transition dairy cows either overfed energy or fed a controlled energy diet prepartum. J Comp Physio B. 2016 186(4):513-25

101. Gioia G, Werner B, Nydam DV, Moroni P. Validation of a mycoplasma molecular diagnostic test and distribution of Mycoplasma species in bovine milk among New York dairy farms. J Dairy Sci. 2016; 99(6):4668-4677

102. *Mann S, Nydam DV, Lock A, Overton TR, McArt JAA. Association of milk fatty acids with early lactation hyperketonemia and elevated concentration of nonesterified fatty acids. J Dairy Sci. 2016 Jul; 99(7):5851-7

103. *Mann S, Abuelo A, Nydam DV, Leal Yepes FA, Overton TR, Wakshlag JJ. Insulin signaling, inflammation, and lipolysis in transition dairy cows either overfed energy during the prepartum period or fed a controlled energy diet. J Dairy Sci. 2016 Aug;99(8):6737-52

104. Ospina PA, Rota N, Locatelli C, Colombo L, Pollera C, Giacinti G, Bronzo V, Casula A, Arpinelli A, Brossette V, Facchi M, Patelli A, Ruggeri A, Barberio A, Potenza G, Nydam DV, Moroni P. Randomized noninferiority field-trial comparing two first generation cephalosporin products at the dry-off. J Dairy Sci. 2016 99(8):1-13

105. *Vasquez A, Nydam DV, Capel MB, Ceglowski B, Rauch BJ, Thomas MJ, Tikofsky L, Watters RD, Zuidhof S, Zurakowski MJ. Randomized noninferiority trial comparing two commercial intramammary antibiotics for the treatment of nonsevere clinical mastitis in dairy cows. J Dairy Sci. 2016 Oct;99(10):8267-81

106. *Wieland, M, Mann S, Guard CL, Nydam DV. The influence of three different navel dips on umbilical involution, calf health, and growth performance. J Dairy Sci. 2017 Jan; 100 (1):513-524

107. * Vasquez A, Nydam DV, Capel MB, Eicker S Virkler PD. Clinical outcome comparison of immediate blanket treatment versus a delayed pathogen-based treatment protocol for clinical mastitis in a New York dairy herd. J Dairy Sci. 2017 Apr; 100(4):2992-3003

108. *Caixeta LS, Ospina PA, Capel MB, Nydam DV. Association between subclinical hypocalcemia in the first 3 days of lactation and reproductive performance of dairy cows. Therio. 2017 May; 94:1-7

• B.S. - 1969 BS, Biological Sciences, with distinction; Cornell University, College of Agriculture
• DVM - 1972 DVM with distinction; Cornell University, New York State College of Veterinary Medicine

• 1974 - 1975 Instructor, Large Animal Medicine, Obstetrics, and Surgery (LAMOS), Ambulatory Clinic; College of Veterinary Medicine, Cornell University, Ithaca, New York
• 1978 - 1979 Visiting Research Assistant, Institute Nationale de la Recherche Agronomique, Jouy‑en‑Josas, France
• 1975 - 1983 Assistant Professor of Medicine, Ambulatory Clinic; College of Veterinary Medicine, Cornell University, Ithaca, New York
• 1983 - 1998 Associate Professor of Medicine, Department of Clinical Sciences; College of Veterinary Medicine, Cornell University, Ithaca, New York
• 1986 - 1987 Visiting Professor , Ruminant Medicine Clinic [II Medizinische Tierklinik], headed by Professor G. Dirksen; University of Munich, Munich, Germany
• 1993 - 1994 Visiting Veterinarian, Ministry of Agriculture, Fisheries and Food Veterinary Diagnostic Lab; Preston, UK
• 1998 - 2005 Associate Professor of Ambulatory and Production Medicine; College of Veterinary Medicine, Cornell University, Ithaca, New York.
• 2006 - present Professor of Ambulatory and Production Medicine; College of Veterinary Medicine, Cornell University, Ithaca, New York.

1. Linklater KA, Smith MC. Colour Atlas of Diseases and Disorders of the Sheep and Goat, Wolfe Publishing Ltd., London, England, 1993.
2. Smith MC, Sherman DM. Goat Medicine, 2nd edition. Ames, IA, Blackwell, 2009
3. Wiedmann M, Czajka J, Baat N, Bodis M, Smith MC, Divers TJ, Batt CA. Diagnosis and epidemiological association of Listeriamonocytogenes strains in two outbreaks of listerial encephalitis in small ruminants. Journal of Clinical Microbiology 32:991-996; 1994.
4. Wiedmann M, Arvik T, Bruce JL, Neubauer J, del Piero F, Smith MC, Hurley J, Mohammed HO, Batt CA. Investigation of a listeriosis epizootic in sheep in New York state. American Journal of Veterinary Research 58:733-737; 1997.
5. Delgado-Lecaroz R, Warnick LD, Guard CL, Smith MC, Barry DA. Cross-sectional study of the association of abomasal displacement or volvulus with serum electrolyte and mineral concentrations in dairy cows. Canadian Veterinary Journal 41:301-305;2000.
6. Barr SC, Linke RA, Janssen D, Guard CL, Smith MC, Daugherty CS, Scarlett JM. Detection of biofilm formation and nanobacteria under long-term cell culture conditions in serum samples of cattle, goats, cats, and dogs. American Journal of Veterinary Research 64:176-182; 2003.
7. Evans K, Smith M, McDonough P, Wiedmann M. Eye infections due to Listeria monocytogenes in three cows and one horse. Journal of Veterinary Diagnostic Investigation 16:464-469; 2004.
8. Daley LP, Gagliardo LF, Duffy MS, Smith MC, Appleton JA. Application of monoclonal antibodies in functional and comparative investigations of heavy-chain immunoglobulins in New World camelids. Clinical and Diagnostic Laboratory Immunology 12:380-386; 2005.
9. Smith MC. Veterinary experiences with the Cornell STAR system of accelerated lambing. Small Ruminant Research 62:125-128, 2006.
10. Nedrow AJ, Gavalchin J, Smith MC, Stehman SM, Maul JK, McDonough SP and Thonney ML: Antibody and skin-test responses of sheep vaccinated against Johne's Disease. Veterinary Immunology and Immunopathology 117:109-112, 2007.
11. Breed MW, Guard CL, White ME, Smith MC, and Warnick LD: Comparison of pregnancy diagnosis in dairy cattle by use of a commercial ELISA and palpation per rectum. Journal of the American Veterinary Medical Association 235:292-298, 2009.
12. Daley LP, Kutzler MA, Bennett BW, Smith MC, Glaser AL, and Appleton JA: Effector Functions of Camelid Heavy-Chain Antibodies in Immunity to West Nile Virus. Clinical and Vaccine Immunology 17(2):239-246, 2010.
13. McComb TK, Bischoff K, Thompson B, Smith MC, Mohammed HO, Ebel J, and Hillebrandt J: An investigation of blood selenium concentrations of goats in New York State. J Vet Diagn Invest 22:696-701, 2010.
14. Ermilio EM and Smith MC: Treatment of emergency conditions in sheep and goats. Veterinary Clinics North America Food Animal 27:33-45, 2011.

• Studying host-parasite interactions that involves disciplines like pathology, immunology, molecular biology and gastroenterology
• Developing diagnostics for veterinary parasites/pathogens
• Studying biodiversity of parasites of North American wildlife

• Doctor of Philosophy – Ph.D.,  2011 University of Calgary; Alberta, Canada
• Master of Veterinary Sciences (Parasitology) – M.V.Sc., 2001 Acharya N.G. Ranga Agricultural University, Hyderabad, India
• Bachelor of Veterinary Sciences & Animal Husbandry - B.V.Sc. & A.H., 1999 Rajiv Gandhi College of Veterinary & Animal Sciences, Pondicherry University, Pondicherry, India

• 2016-2016: Specialist – Diagnostic Parasitology, Diagnostic Service Unit, Faculty of Veterinary Medicine, University of Calgary
• 2010-2016: Wildlife Parasitologist, Canadian Wildlife Health Cooperative (CWHC), Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Canada
• 2002-2004: Senior Research Fellow, Department of Veterinary Parasitology, Indian Veterinary Research Institute, Bareilly, India
• 2001-2002: Senior Research Fellow & Research Associate Department of Veterinary Parasitology, College of Veterinary Science, Tirupati, India

1. Chaudhry, U., Van Paridon, B., Lejeune, M., Shabbir, M.Z., Rashid, M.R., Ashraf, K., Ashraf, S., Gilleard, J., Sargison, N., 2017, Morphological and molecular identification of Explanatum explanatum in domestic water buffalo in Pakistan. Veterinary Parasitology: Regional Studies and Reports, 8: 54-59
2. Slater, O.M., Peters-Kennedy, J., Lejeune, M., Gummer, D., Macbeth, B., Warren, A., Joseph, T., Li, H., Cunha, C.W., & Duignan, P.J. 2017, Sheep-Associated Malignant Catarrhal Fever–Like Skin Disease in a Free-Ranging Bighorn Sheep (Ovis canadensis), Alberta, Canada. Journal of wildlife diseases, 53(1): 1-6
3. Verocai, G.G.; Lejeune, M.; Skorobohach, B.; Wilcock, B.; Gilleard, J. S. 2016, Onchocerca lupi Nematodes in Dogs Exported from the United States into Canada. Emerging Infectious diseases, 22(8): 1477-79.
4. Pruvot, M., Lejeune, M., Kutz, S.J., Hutchins, W., Musiani, M., Massolo, M., & Orsel, K. 2016, Better Alone or in Ill Company? The Effect of Migration and Inter-species Comingling on Fascioloides magna Infection in Elk. PLos One, 11(7): e0159319.
5. Dergousoff, S.J., Lysyk, T.J., Kutz, S.J., Lejeune, M., & Elkin, B.T. 2016, Human-Assisted Dispersal Results in the Northernmost Canadian Record of the American Dog Tick, Dermacentor variabilis (Ixodida: Ixodidae). Entomological News, 126(2):132-137.
6. Kafle, P., Lejeune, M., Verocai, G.G., Hoberg, E.P., & Kutz, S.J., 2015, Morphological and morphometric differentiation of dorsal-spined first stage larvae of lungworms, (Nematoda: Protostrongylidae) infecting muskoxen (Ovibos moschatus) in the Central Canadian Arctic. International Journal for Parasitology: Parasites and Wildlife. 2015; 4(3):283-90.
7. Catalano, S., Lejeune, M., Tizzani, P., Verocai, G.G., Schwantje, H., Nelson, C., & Duignan, P.J. 2015, Helminths of grizzly and American black bears in Alberta and British Columbia, Canada. Canadian journal of zoology, 93(10):765-772.
8. Catalano, S., Lejeune, M., Van Paridon, B., Pagan, C.A., Wasmuth, J.D., Tizzani, P., Duignan, P.J., Nadler, S.A. 2014, Morphological variability and molecular identification of Uncinaria spp. (Nematoda: Ancylostomatidae) from grizzly and black bears: new species or phenotypic plasticity? Journal of Parasitology, 101(2): 182-92.
9. Lejeune, M., Moreau, F., Chadee, K. 2014, Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering Claudin-4. PLos one, 9(11), e113270.
10. Rothenburger, J.L., Himsworth, C.G., Lejeune, M., Treuting, P.M., Leighton, F.A. 2014, Lesions associated with Eucoleus sp. in the non-glandular stomach of wild urban rats (Rattus norvegicus). International Journal for Parasitology: Parasites and Wildlife, Aug; 3(2): 95–101.
11. Rothenburger, J.L., Himsworth, C.G., Chang, V., Lejeune, M., Leighton, F.A. 2014, Capillaria hepatica in wild Norway rats (Rattus norvegicus) from Vancouver, Canada. Journal of Wildlife Diseases. Jul; 50(3): 628-33
12. Catalano, S., Lejeune, M., Verocai, G.G., Duignan, P.J. 2014, First report of Taenia arctos (Cestoda: Taeniidae) from grizzly (Ursus arctos horribilis) and black bears (Ursus americanus) in North America. Parasitology International, 63(2), 389-391.
13. Verocai, G.G., Lejeune, M., Finstad, G.L., Kutz, S.J. 2013, A Nearctic parasite in a Palearctic host: Parelaphostrongylus andersoni (Nematoda; Protostrongylidae) infecting semi-domesticated reindeer in Alaska. International Journal for Parasitology: Parasites and Wildlife, 2(1), 119-123.
14. Goplen, M., Lejeune, M., Cornick, S., Moreau, F., Chadee, K. 2013, Entamoeba histolytica contains an occludin-like protein that can alter colonic epithelial barrier function. Plos one, 8(9), e73339.
15. Liccioli, S., Duignan, P.J., Lejeune, M., Deunk, J., Majid, S. & Massolo, A. 2013, A new intermediate host for Echinococcus multilocularis: The southern red-backed vole (Myodes gapperi) in urban landscape in Calgary, Canada. Parasitology International, 62(4), 355-357.
16. Verocai, G.G., Schock, D.M., Lejeune, M., Warren, A.L., Duignan, P.J. & Kutz, S.J. 2013, Oslerus osleri (Metastrongyloidea; Filaroididae) in Gray Wolves (Canis lupus) from Banff National Park, Alberta, Canada. Journal of Wildlife Diseases. Apr; 49(2): 422-6.
17. Lavikainen, A., Haukisalmi, V., Deksne, G., Holmala, K., Lejeune, M., Isomursu, M., Jokelainen, P., Näreaho, A., Laakkonen, J., Hoberg, E.P. & Sukura, A. 2013, "Molecular identification of Taenia spp. in the Eurasian lynx (Lynx lynx) from Finland", Parasitology, vol. 140, no. 5, pp. 653-662.
18. Verocai, G.G., Lejeune, M., Beckmen, K.B., Kashivakura, C.K., Veitch, A.M., Popko, R.A., Fuentealba, C., Hoberg, E.P. & Kutz, S.J. 2012, "Defining parasite biodiversity at high latitudes of North America: New host and geographic records for Onchocerca cervipedis (Nematoda: Onchocercidae) in moose and caribou", Parasites & Vectors, pp. 242.
19. Catalano, S*., Lejeune, M*., Liccioli, S., Verocai, G.G., Gesy, K.M., Jenkins, E.J., Kutz, S.J., Fuentealba, C., Duignan, P.J. & Massolo, A. 2012, "Echinococcus multilocularis in urban coyotes, Alberta, Canada", Emerging Infectious Diseases, vol. 18, no. 10, pp. 1625-1628. [* Denotes equal contribution]
20. Liccioli, S., Catalano, S., Kutz, S.J., Lejeune, M., Verocai, G.G., Duignan, P.J., Fuentealba, C., Hart, M., Ruckstuhl, K.E. & Massolo, A. 2012, "Gastrointestinal parasites of coyotes (Canis latrans) in the metropolitan area of Calgary, Alberta, Canada", Canadian journal of zoology, vol. 90, no. 8, pp. 1023-1030.
21. Liccioli, S., Catalano, S., Kutz, S.J., Lejeune, M., Verocai, G.G., Duignan, P.J., Fuentealba, C., Ruckstuhl, K.E. & Massolo, A. 2012, "Sensitivity of double centrifugation sugar fecal flotation for detecting intestinal helminths in coyotes (Canis latrans)", Journal of wildlife diseases, vol. 48, no. 3, pp. 717-723.
22. Saravanan, B.C., Bansal, G.C., Manigandan, L., Sankar, M., Ravindran, R. & Rao, J.R. 2011, "Development of a non-radioactive probe generated by RAPD-PCR for the detection of Theileria annulata", Indian Journal of Animal Sciences, vol. 81, no. 11, pp. 1089-1092.
23. Lejeune, M., Moreau, F. & Chadee, K. 2011, "Prostaglandin E2 produced by Entamoeba histolytica signals via EP4 receptor and alters claudin-4 to increase ion permeability of tight junctions", American Journal of Pathology, vol. 179, no. 2, pp. 807-818.
24. Lejeune, M., Leung, P., Beck, P.L. & Chadee, K. 2010, "Role of EP4 receptor and prostaglandin transporter in prostaglandin E2-induced alteration in colonic epithelial barrier integrity", American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 299, no. 5, pp. G1097-G1105.
25. Hirota, S.A., Fines, K., Ng, J., Traboulsi, D., Lee, J., Ihara, E., Li, Y., Willmore, W.G., Chung, D., Scully, M.M., Louie, T., Medlicott, S., Lejeune, M., Chadee, K., Armstrong, G., Colgan, S.P., Muruve, D.A., MacDonald, J.A. & Beck, P.L. 2010, "Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury", Gastroenterology, vol. 139, no. 1, pp. 259-269.
26. Lejeune, M.*, Rybicka, J.M*. & Chadee, K. 2009, "Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica", Future Microbiology, vol. 4, no. 1, pp. 105-116. [* Denotes equal contribution]
27. Dey, I.*, Lejeune, M.* & Chadee, K. 2006, "Prostaglandin E2 receptor distribution and function in the gastrointestinal tract", British journal of pharmacology, vol. 149, no. 6, pp. 611-623. [* Denotes equal contribution]
     

Updated list: http://www.researchgate.net/profile/Manigandan_Lejeune/publications