The Department of Molecular Medicine hosts seminars and research Work-in-Progress presentations throughout the year

Spring Seminar Series 2025
4:00 pm  (Mondays, Lecture Hall III, unless otherwise noted)

April 2025

• April 14
  Sevan Hopyan, Departments of Molecular Genetics and Surgery, University of Toronto
  How Stiffness Geometry can Shape Embryonic Tissues
  (Hosted by Natasza Kurpios)

Fall 2024 / Spring 2025 Department Work-In-Progress Series
4:00 pm Mondays, Lecture Hall III, unless noted otherwise

OCTOBER 2024

• October 21
  Derek Wei (Hollopeter Lab) - ASPPs multimerize protein phosphatase I

• October 28
  Matt Zanotelli  (Cerione Lab) - A Dock7-mTOR complex sustains AKt and S8K activity necessary for stress survival in cancer
  Jenn Roscoe (Sevier Lab) - How do cells use the unfolded protein response to manage ER over-oxidation?

NOVEMBER 2024

• November 4
  Rebecca Schmitt (Cerione Lab)  - Gliobastoma resilience through Doc7-mediated survival and plasticity
  Kuang-Tse Wang (Adler Lab)  - RoboA/Anos1 spacially restricts pharynx cell fates in planarians

• November 11 
  Jillian Breault (Sevier Lab) - Understanding the Hsp70 molecular chaperone cycle through structure-function studies of spontaneous suppressor mutations
  Bill Katt (Cerione Lab) - Oral cancer in four legged friends

• November 18
  Shun Enomoto (Cerione Lab) - Embryonic stem cell-derived extracellular vesicles delay cellular senescence by inhibiting oxidative stress
  Sumanth Mosale (Sardana Lab) - Loss of cystinosin promotes abnormal glycosylation

• November 25 - No WIP, Thanksgiving Break

DECEMBER 2024

• December 2
  Sarah Chan  (Kawate Lab) - Elucidating the biochemical role of the TTYH protein family in the nervous system
  Saul De La Penn (Cerione Lab) - Unraveling the biology and structure of the rhodopsin signaling pathway in the presence of native lipids

• December 9
  Justin Tapper  (Adler Lab) - Developing transgenic strategies in planaria
  Jessica Holchek (Cerione Lab) - Investigating the mechanism of phosphodiesterase-6 activation by electron spin resonance spectroscopy techniques

• December 16
  Libby Huang (Kurpios Lab) - The role of Pitx2 in villus smooth muscle-lymphatics complex
  Alexandra Hommer (Sevier Lab) - The role of sub cellular protein methionine oxidation and methionine sulfide reductase activities in aging

• December 23 - NO WIP, Winter Break

• December 30 - NO WIP, Winter Break

JANUARY 2025

• January 6
  Katie Crowther (Kawate Lab) - Elucidation of the mechanism and physiological function of TMEM94
  Jac Longstreth (Cerione Lab) - Targeting glutamine metabolism in virus infection

• January 13
  Jade Bowerman  (Sardana Lab) - Understanding function and cargo of the AP-1 sub-complexes in S. cerevisiae
  Yongsheng Wang (Cerione Lab) - Palmitoylation as a mechanism for regulating extracellular vesicle cargo and function

• January 20 - NO WIP, Martin Luther King Jr. Holiday

• January 27 - NO WIP, BBS Recruitment

FEBRUARY 2025

• February 3
  Biswanath Shaw  (Cerione Lab) - Investigating the interaction between activated Cdc42 and Dock67DHR2 through structural studies
  Isabel Delo (Adler Lab) - Investigating the role of Smad4-2 in the regeneration of a neural feeding circuit

• February 10
  Jacob Neumann (Cerione Lab) - Survivin promotes the Warburg Effect in KRAS-dependent cancer cells by interacting with a key metabolic enzyme           
  Fu-Yu Tsai (Adler Lab) - Brains everywhere! Regulation of neurogenesis in planarians

• February 17
  Yangyang Liu (Cerione Lab) - Cancer-derived extracellular vesicles induce the formation of Cancer-associated-fibroblasts through AKT activation
  Julia Zhu  (Sardana Lab) - The solute transporter Ers1 regulates ER/Golgi redox in yeast

• February 24
  Kayleigh Morrison  (Hollopeter Lab) – Determining the function of the MLT-4 amphipathic helix
  Yifan Fang  (Cerione Lab) - SIRT5 regulates the degradation of glutaminase C in breast cancer

MARCH 2025

• March 3
  Trisha Bhattacharya  (Ichikawa Lab) - Expanding the Chemical Biology Toolbox for Exploring and Repurposing Protein Modifications
  Sam Deck (Cerione Lab) - Revealing Functional Hotspots: Temperature-Dependent Crystallography of K-RAS Highlights Allosteric and Druggable Sites