Research on mechanisms of bacterial pathogenesis in the lung and gut use mouse models to study bacteria of global public health interest. A strong Mycobacterium tuberculosis (M.tb) group focus on the crosstalk between M.tb and host myeloid cells using innovative in vivo models (Russell) and through targeting lipid metabolism for new drug discovery (VanderVen).  Work on Salmonella virulence drives new vaccine and therapeutic approaches targeting typhoid toxin (Song). At a more microbial systems level, the Kimura lab seeks to define how microorganisms regulate protein synthesis by studying tRNA modifications that optimize codon decoding.  While studies of the microbiome focus on microbial small-molecule metabolites that regulate inflammation (Chang).

	Pamela Chang, PhD  Associate Professor of Immunology Identification of metabolites produced by the gut microbiota that regulate the host immune system and the development of chemical tools to modulate the immune response
	Satoshi Kimura, PhD Assistant Professor of Microbial Pathogenesis Gene expression regulation of bacterial pathogens in the host
	David Russell, PhD William Kaplan Professor of Infection Biology The biology of intracellular infection, with emphasis on Mycobacteria
	Jeongmin Song, PhD Associate Professor of Bacterial Pathogenesis Typhoid toxin, Salmonella Typhi, Bacterial AB toxins, Vaccines, Antibodies, Typhoid fever, Chronic/persistent infection
	Brian VanderVen, PhD Associate Professor of Bacteriology Physiology of the intracellular pathogen M. tuberculosis