The Clinical Pathology Laboratory is in the Department of Population Medicine and Diagnostic Sciences, and is also a unit of the Animal Health Diagnostic Center at Cornell University. The Laboratory is staffed by four clinical pathologists, all of whom are board-certified by the American College of Veterinary Pathologists, a laboratory manager, multiple medical technologists and veterinary technicians, and three administrative assistants. We also have three training positions including two clinical pathology residents and one intern. We have a high-volume, high-quality laboratory equipped with state-of-the-art analyzers. We provide diagnostic testing and professional consultation services to the Cornell University Hospital for Animals, to researchers affiliated with Cornell University and to private veterinary practitioners and researchers throughout New York, the USA, and worldwide.
Order Clinical Pathology Tests
The clinical pathology section is an academic unit with three mandates:
- Professional diagnostic service: We are committed to performing high-quality, timely, comprehensive, and accurate laboratory testing of animal specimens in the areas of hematology, clinical chemistry, diagnostic cytology, immunology, and urinalysis. As part of this service, we provide professional consultation for our laboratory results.
- Education: We are dedicated to educating current and future veterinarians in clinical pathology through our residency program, interactive case-based lectures, laboratories and seminars, elective laboratory rotations for students, interns and residents, and web-based educational resources (see eClinPath).
- Research: We are committed to contributing to the advancement of knowledge in clinical pathology through investigative research. Our faculty and residents are actively involved in clinical applied research, which is a vital component of our residency training program. Current research areas of interest are:
- Hematopoietic neoplasia, such as leukemia and lymphoma
- Thrombotic disorders in animals
- Hematologic disorders, including iron deficiency anemia and immune-mediated hemolytic anemia
Services
Testing
People
Research
Clinical Pathology performs testing for a variety of researchers and contract laboratories. We can create customized panels, consisting of specific tests for research projects. We also provide consultation on study design (if desired), how to submit samples (with examples of request forms), and guidance on optimal sample collection, labeling, and shipping.
For all research projects, the project leader (or designated representative) must contact our laboratory manager before any samples can be accepted for analysis. We will require the following information when setting up a research account:
- Lipid abnormalities
- Hematologic disorders, such as immune-mediated hemolytic anemia
- Hematopoietic neoplasia, such as leukemia and lymphoma
- Thrombotic disorders in animals
The laboratory manager will use this information to formulate a plan so your research project will be performed in the most efficient manner possible.
For publications from the clinical pathology crew from the past 2 years, please see below.
2020-2022 Publications
- Acute phase protein response and changes in lipoprotein particle size in dogs with systemic inflammatory response syndrome.
Behling-Kelly E, Haak CE, Carney P, Waffle J, Eaton K, Goggs R.J Vet Intern Med. 2022 May;36(3):993-1004. doi: 10.1111/jvim.16420. Epub 2022 Apr 14.PMID: 35420224 Free PMC article. - Complete blood count and biochemistry reference intervals for healthy adult sheep in the northeastern United States.
Frye EA, Behling-Kelly EL, Lejuene M, Webb JL.Vet Clin Pathol. 2022 Mar;51(1):119-125. doi: 10.1111/vcp.13059. Epub 2022 Feb 27.PMID: 35224766 Review. - Lipoprotein profile of pleural and peritoneal transudates in dogs and cats.
Alonso FH, Behling-Kelly E, Borjesson DL.J Vet Intern Med. 2022 Mar;36(2):464-472. doi: 10.1111/jvim.16369. Epub 2022 Feb 15.PMID: 35166405 Free PMC article. - Granular variant of a histiocytic tumor on the toe of a cat: Case report and literature review.
Cruz Otero JD, Jager M, Armien AG, Miller A, Stokol T.Vet Clin Pathol. 2022 Jun 24. doi: 10.1111/vcp.13152. Online ahead of print. PMID: 35751153 - Case-control exercise challenge study on the pathogenesis of high serum gamma-glutamyl transferase activity in racehorses.
Mann S, Abuelo A, Stokol T, Wakshlag JJ, Bayly W, Reed S, Gandy J, Ramsay JD, Divers TJ.Equine Vet J. 2022 May 2. doi: 10.1111/evj.13584. Online ahead of print. PMID: 35491961 - Editorial: Comparative Oncology-Advances in Veterinary Molecular Oncology.
Meichner K, McCleary-Wheeler AL, Mochizuki H, Stokol T.Front Vet Sci. 2022 Jan 12;8:812856. doi: 10.3389/fvets.2021.812856. eCollection 2021.PMID: 35097056 Free PMC article. No abstract available. - A Urinary Drug-Disposing Approach as an Alternative to Intravesical Chemotherapy for Treating Nonmuscle Invasive Bladder Cancer.
Bellat V, Michel AO, Thomas C, Stokol T, Choi BB, Law B.Cancer Res. 2022 Apr 1;82(7):1409-1422. doi: 10.1158/0008-5472.CAN-21-2897.PMID: 35039320 Free PMC article. - Investigating the pathogenesis of high-serum gamma-glutamyl transferase activity in Thoroughbred racehorses: A series of case-control studies.
Mann S, Ramsay JD, Wakshlag JJ, Stokol T, Reed S, Divers TJ.Equine Vet J. 2022 Jan;54(1):39-51. doi: 10.1111/evj.13435. Epub 2021 Mar 8.PMID: 33555643 - Pharmacokinetics, pharmacodynamics and safety evaluation of 5,5'-methylenebis(2-acetoxybenzoic acid) in dogs following intravenous administration.
Goggs R, Kannampuzha-Francis J, Campbell CJ, Moreau JP, Behling-Kelly E.Vet Immunol Immunopathol. 2021 Dec;242:110339. doi: 10.1016/j.vetimm.2021.110339. Epub 2021 Oct 14.PMID: 34715602 - Hepatic effects of rumen-protected branched-chain amino acids with or without propylene glycol supplementation in dairy cows during early lactation.
Leal Yepes FA, Mann S, Overton TR, Behling-Kelly E, Nydam DV, Wakshlag JJ.J Dairy Sci. 2021 Sep;104(9):10324-10337. doi: 10.3168/jds.2021-20265. Epub 2021 Jun 25.PMID: 34176626 - Osteogenesis Imperfecta in Two Finnish Lapphund Puppies.
Tse MY, Porter IR, Demeter E, Behling-Kelly E, Wakshlag JJ, Miller AD.Vet Med (Auckl). 2021 Jun 17;12:177-185. doi: 10.2147/VMRR.S308418. eCollection 2021.PMID: 34168973 Free PMC article. - Review of Histological Grading Systems in Veterinary Medicine.
Avallone G, Rasotto R, Chambers JK, Miller AD, Behling-Kelly E, Monti P, Berlato D, Valenti P, Roccabianca P.Vet Pathol. 2021 Sep;58(5):809-828. doi: 10.1177/0300985821999831. Epub 2021 Mar 26.PMID: 33769136 Free article. Review. - American Society for Veterinary Clinical Pathology-Recommended Clinical Pathology Competencies for Graduating Veterinarians.
Newman AW, Moller CA, Evans SJM, Viall A, Baker K, Schaefer DMW.J Vet Med Educ. 2021 Sep 3:e20210004. doi: 10.3138/jvme-2021-0004. Online ahead of print.PMID: 34491154 - Influence of locoregional lymph node aspiration cytology vs sentinel lymph node mapping and biopsy on disease stage assignment in dogs with integumentary mast cell tumors.
Lapsley J, Hayes GM, Janvier V, Newman AW, Peters-Kennedy J, Balkman C, Sumner JP, Johnson P.Vet Surg. 2021 Jan;50(1):133-141. doi: 10.1111/vsu.13537. Epub 2020 Nov 10.PMID: 33169849 - What is your diagnosis? Hepatocytes from a cat.
Haak CE, Webb JL.Vet Clin Pathol. 2021 Mar;50(1):95-97. doi: 10.1111/vcp.12959. Epub 2021 Jan 14.PMID: 33448068 - Three of these things….
Held EP, Webb JL. Vet Clin Pathol. 2021 Sep;50(3):317-318. doi: 10.1111/vcp.13072.PMID: 34585405 - Hematologic and Biochemical Reference Intervals and Urinary Test Results for Wild-caught Adult Southern Giant Pouched Rats (Cricetomys ansorgei).
Stokol T, Brandt LE, Shuman M, Jeffery DA, Blank B, Silvela E, Singh B.J Am Assoc Lab Anim Sci. 2021 Nov 1;60(6):616-629. doi: 10.30802/AALAS-JAALAS-20-000154. Epub 2021 Aug 27.PMID: 34452657 Free PMC article. - What is your diagnosis? Impression smear from a liver mass in a dog.
Shiprack C, Miranda IC, McDonough SP, Stokol T.Vet Clin Pathol. 2021 Jun;50(2):290-292. doi: 10.1111/vcp.12952. Epub 2021 Mar 8.PMID: 33682944 No abstract available. - Assay variability and storage stability of the myeloperoxidase index of the ADVIA 2120i hematology analyzer in canine and equine whole blood samples.
Chu SAA, Stokol T.Vet Clin Pathol. 2021 Mar;50(1):28-36. doi: 10.1111/vcp.12981. Epub 2021 Mar 2.PMID: 33655602 - Detection of Epithelial Cell Adhesion Molecule in Feline Normal and Tumor Cell Lines and Tissues With Selected Commercial Anti-human EpCAM Antibodies.
Heyward CY, Dong L, Shakhzadyan H, Wan C, Stokol T.Front Vet Sci. 2021 Feb 4;8:622189. doi: 10.3389/fvets.2021.622189. eCollection 2021.PMID: 33614766 Free PMC article. - Sars-CoV-2 infection and longitudinal fecal screening in Malayan tigers (Panthera Tigris Jacksoni), Amur tigers (Panthera Tigris Altaica), and African lioins (Panthera Leo Krugeri) at the Bronx Zoo, New York, USA.
Bartlett SL, Diel DG, Wang L, Zec S, Laverack M, Martins M, Caserta LC, Killian ML, Terio K, Olmstead C, Delaney MA, Stokol T, Ivančić M, Jenkins-Moore M, Ingerman K, Teegan T, McCann C, Thomas P, McAloose D, Sykes JM, Calle PP.J Zoo Wildl Med. 2021 Jan;51(4):733-744. doi: 10.1638/2020-0171.PMID: 33480553 - PAR1 regulation of CXCL1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus.
Antoniak S, Tatsumi K, Schmedes CM, Egnatz GJ, Auriemma AC, Bharathi V, Stokol T, Beck MA, Griffin JH, Palumbo JS, Mackman N.J Thromb Haemost. 2021 Apr;19(4):1103-1111. doi: 10.1111/jth.15221. Epub 2021 Feb 19.PMID: 33346953 Free PMC article. - Influence of handler relationships and experience on health parameters, glucocorticoid responses and behaviour of semi-captive Asian elephants.
Crawley JAH, Liehrmann O, Franco Dos Santos DJ, Brown J, Nyein UK, Aung HH, Htut W, Oo ZM, Seltmann MW, Webb JL, Lahdenperä M, Lummaa V.Conserv Physiol. 2021 Jan 6;9(1):coaa116. doi: 10.1093/conphys/coaa116. eCollection 2021.PMID: 34676079 Free PMC article. - Practical Tips on Sample Handling for Hematology, Chemistry, and Cytology Testing for Equine Patients:: Getting More Bang for your Buck.
Newman AW.Vet Clin North Am Equine Pract. 2020 Apr;36(1):1-14. doi: 10.1016/j.cveq.2019.12.002. Epub 2020 Jan 24.PMID: 31987706 - The effect of ex vivo lipopolysaccharide stimulation and nutrient availability on transition cow innate immune cell AKT/mTOR pathway responsiveness.
Sipka AS, Chandler TL, Behling-Kelly EL, Overton TR, Mann S.J Dairy Sci. 2020 Feb;103(2):1956-1968. doi: 10.3168/jds.2019-17307. Epub 2019 Dec 19.PMID: 31864738 Free article. - Clinicopathologic Findings of Spontaneous Leukemia in 9 Pet African Hedgehogs (Atelerix Albiventris).
Koizumi I, Hernandez-Muguiro D, Chu SAA, Stokol T, Asakawa MG.Front Vet Sci. 2020 Feb 11;7:54. doi: 10.3389/fvets.2020.00054. eCollection 2020.PMID: 32118073 Free PMC article. - Agreement of stall-side and laboratory major crossmatch tests with the reference standard method in horses.
Fenn MS, Bortsie-Aryee AD, Perkins GA, Mann S, Tomlinson JE, Wood EM, Mix SE, Stokol T.J Vet Intern Med. 2020 Mar;34(2):941-948. doi: 10.1111/jvim.15710. Epub 2020 Feb 4.PMID: 32017276 Free PMC article. - Editorial: Current Research in Equid Herpesvirus Type-1 (EHV-1).
Stokol T, Soboll Hussey G.Front Vet Sci. 2020 Jan 10;6:492. doi: 10.3389/fvets.2019.00492. eCollection 2019.PMID: 31998768 Free PMC article. - Hematology Red Flags: The Value of Blood Smear Examination in Horses.
Stokol T.Vet Clin North Am Equine Pract. 2020 Apr;36(1):15-33. doi: 10.1016/j.cveq.2019.11.001. Epub 2020 Jan 18.PMID: 31959376 Review. - Aldoxorubicin-loaded nanofibers are cytotoxic for canine mammary carcinoma and osteosarcoma cell lines in vitro: A short communication.
Stokol T, Wan C, Blakely R, Bellat V, Law B.Res Vet Sci. 2020 Feb;128:86-89. doi: 10.1016/j.rvsc.2019.11.003. Epub 2019 Nov 12.PMID: 31760317 - Technical note: Effect of storage time and temperature on total calcium concentrations in bovine blood.
Bach KD, Neves RC, Stokol T, McArt JAA.J Dairy Sci. 2020 Jan;103(1):922-928. doi: 10.3168/jds.2019-17394. Epub 2019 Nov 14.PMID: 31733856 - Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2): A Perspective Through the Lens of the Veterinary Diagnostic Laboratory.
Stokol T, McAloose D, Terio KA, Salguero FJ.Front Vet Sci. 2020 Sep 25;7:576267. doi: 10.3389/fvets.2020.576267. eCollection 2020.PMID: 33088836 Free PMC article. - From People to Panthera: Natural SARS-CoV-2 Infection in Tigers and Lions at the Bronx Zoo.
McAloose D, Laverack M, Wang L, Killian ML, Caserta LC, Yuan F, Mitchell PK, Queen K, Mauldin MR, Cronk BD, Bartlett SL, Sykes JM, Zec S, Stokol T, Ingerman K, Delaney MA, Fredrickson R, Ivančić M, Jenkins-Moore M, Mozingo K, Franzen K, Bergeson NH, Goodman L, Wang H, Fang Y, Olmstead C, McCann C, Thomas P, Goodrich E, Elvinger F, Smith DC, Tong S, Slavinski S, Calle PP, Terio K, Torchetti MK, Diel DG.mBio. 2020 Oct 13;11(5):e02220-20. doi: 10.1128/mBio.02220-20.PMID: 33051368 Free PMC article. - Leukocyte and Platelet Characteristics of the Giant Panda (Ailuropoda melanoleuca): Morphological, Cytochemical, and Ultrastructural Features.
Kehoe SP, Stacy NI, Frasca S Jr, Stokol T, Wang C, Leach KS, Luo L, Rivera S.Front Vet Sci. 2020 Mar 24;7:156. doi: 10.3389/fvets.2020.00156. eCollection 2020.PMID: 32266298 Free PMC article. - Multicenter flow cytometry proficiency testing of canine blood and lymph node samples.
Meichner K, Stokol T, Tarigo J, Avery A, Burkhard MJ, Comazzi S, Fogle J, Stowe DM, Rütgen B, Seelig D, Wasserkrug-Naor A, Vernau W, Bienzle D.Vet Clin Pathol. 2020 Jun;49(2):249-257. doi: 10.1111/vcp.12843. Epub 2020 Apr 4.PMID: 32246538 Free article.
2018-2019 Publications
- C1 inhibitor in canine intravascular hemolysis (C1INCH): study protocol for a randomized controlled trial.
Goggs R, Behling-Kelly E.BMC Vet Res. 2019 Dec 30;15(1):475. doi: 10.1186/s12917-019-2220-2.PMID: 31888626 Free PMC article. - Candida albicans cholecystitis with associated hepatitis in a cat.
Palermo SM, Newman AW, Koch MW. JFMS Open Rep. 2019 Jun 12;5(1):2055116919854165. doi: 10.1177/2055116919854165. eCollection 2019 Jan-Jun.PMID: 31218075 - The effect of the transition period and postpartum body weight loss on macrophage infiltrates in bovine subcutaneous adipose tissue.
Newman AW, Miller A, Leal Yepes FA, Bitsko E, Nydam D, Mann S. J Dairy Sci. 2019 Feb;102(2):1693-1701. doi: 10.3168/jds.2018-15362. Epub 2018 Nov 22.PMID: 30471901 - Clinical Pathology of Donkeys and Mules.
Goodrich EL, Behling-Kelly E. Vet Clin North Am Equine Pract. 2019 Dec;35(3):433-455. doi: 10.1016/j.cveq.2019.08.002. Review.PMID: 31672198 - Sex-specific hepatic lipid and bile acid metabolism alterations in Fancd2-deficient mice following dietary challenge.
Moore ES, Daugherity EK, Karambizi DI, Cummings BP, Behling-Kelly E, Schaefer DMW, Southard TL, McFadden JW, Weiss RS. J Biol Chem. 2019 Oct 25;294(43):15623-15637. doi: 10.1074/jbc.RA118.005729. Epub 2019 Aug 21.PMID: 31434739 - SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.
Huang L, Chambliss KL, Gao X, Yuhanna IS, Behling-Kelly E, Bergaya S, Ahmed M, Michaely P, Luby-Phelps K, Darehshouri A, Xu L, Fisher EA, Ge WP, Mineo C, Shaul PW. Nature. 2019 May;569(7757):565-569. doi: 10.1038/s41586-019-1140-4. Epub 2019 Apr 24.PMID: 31019307 - What is your diagnosis? Swab of an eyelid swelling from a tomato frog.
Stokol T, Fefer G, Lejeune M, Steeil J, Neiffer D. Vet Clin Pathol. 2019 Sep;48(3):490-492. doi: 10.1111/vcp.12737. Epub 2019 Apr 23. No abstract available.PMID: 31012977 - Evaluation of automated erythrocyte methodology in new world camelids using the ADVIA 2120 hematology analyzer.
Viesselmann LC, Flatland B, Stokol T, Sisson S, Schaefer DMW. Vet Clin Pathol. 2019 Jun;48(2):239-249. doi: 10.1111/vcp.12733. Epub 2019 Jun 9.PMID: 31179576 - Rapid clinical progression of B-cell chronic lymphocytic leukemia in a horse.
Long AE, Javsicas LH, Stokol T, Felippe MJB, Frimberger AE. J Am Vet Med Assoc. 2019 Sep 15;255(6):716-721. doi: 10.2460/javma.255.6.716. - Common bile duct obstruction palliated with common bile duct re-implantation (choledochoduodenostomy) in a cat.
Hayes G, Devereux S, Loftus JP, Jager M, Duhamel G, Stokol T. Can Vet J. 2019 Oct;60(10):1089-1093.PMID: 31597994 - Immunohistochemical Labeling of Low-Density Lipoprotein Receptor and Scavenger Receptor Class B Type 1 Are Increased in Canine Lymphoma.
Ceres K, Fitzgerald H, Quiznon KS, McDonough S, Behling-Kelly E. Frontiers in Veterinary Science. 2018;5:340. doi: 10.3389/fvets.2018.00340. Epub 2019 Jan 11.PMID: 30687727 - Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration.
Serpa PBS, Brooks MB, Divers T, Ness S, Birschmann I, Papich MG, Stokol T. Frontiers in Veterinary Science. 2018 Dec;5:304. doi: 10.3389/fvets.2018.00304. Epub 2018 Dec 4.PMID: 30564584 - Functional Peptide Nanofibers with Unique Tumor Targeting and Enzyme-Induced Local Retention Properties.
Bellat V, Ting R, Southard TL, Vahdat L, Molina H, Fernandez J, Aras O, Stokol T, Law B.Adv Funct Mater. 2018 Oct 31;28(44):1803969. doi: 10.1002/adfm.201803969. Epub 2018 Sep 14.PMID: 30505260 - Pharmacokinetics of Human Recombinant C1-Esterase Inhibitor and Development of Anti-Drug Antibodies in Healthy Dogs.
Wong C, Muguiro DH, Lavergne S, Behling-Kelly E, Goggs R. Vet Immunol Immunopathol. 2018 Sep;203:66-72. doi: 10.1016/j.vetimm.2018.08.006. Epub 2018 Aug 23.PMID: 30243377 - A Commercial Soy-Based Phospholipid Emulsion Accelerates Clot Formation in Normal Canine Whole Blood and Induces Hemolysis in Whole Blood from Normal and Dogs with Inflammatory Leukograms.
Behling-Kelly EL, Wakshlag J. J Vet Emerg Crit Care (San Antonio). 2018 May;28(3):252-260. doi: 10.1111/vec.12716. Epub 2018 Apr 6.PMID: 29631333 - Influence of Multiple Reuse and Resterilization Cycles on the Performance of a Bipolar Vessel Sealing Device (LigaSure) Intended for Single Use.
Kuvaldina A, Hayes G, Sumner J, Behling-Kelly E. Vet Surg. 2018 Sep 4. doi: 10.1111/vsu.12948. [Epub ahead of print]PMID: 30180278 - What is Your Diagnosis? Mandibular Mass In a Cat.
Newman AW, Asakawa MG, Stokol T. Vet Clin Pathol. 2018 Sep;47(3):501-502. doi: 10.1111/vcp.12617. Epub 2018 May 14. No abstract available.PMID: 29758098 - Subcutaneous Administration of Low-Molecular-Weight Heparin to Horses Inhibits Ex Vivo Equine Herpesvirus Type 1-Induced Platelet Activation.
Stokol T, Serpa PBS, Brooks MB, Divers T, Ness S. Front Vet Sci. 2018 May 28;5:106. doi: 10.3389/fvets.2018.00106. eCollection 2018.PMID: 29892605 - Dogs with Acute Myeloid Leukemia or Lymphoid Neoplasms (large cell lymphoma or acute lymphoblastic leukemia) May Have Indistinguishable Mediastinal Masses on Radiographs.
Epperly E, Hume KR, Moirano S, Stokol T, Intile J, Erb HN, Scrivani PV. Vet Radiol Ultrasound. 2018 Sep;59(5):507-515. doi: 10.1111/vru.12622. Epub 2018 May 3.PMID: 29726055 - A Retrospective Review of Acute Myeloid Leukaemia in 35 Dogs Diagnosed by a Combination of Morphologic Findings, Flow Cytometric Immunophenotyping and Cytochemical Staining Results (2007-2015). Davis LL, Hume KR, Stokol T. Vet Comp Oncol. 2018 Jun;16(2):268-275. doi: 10.1111/vco.12377. Epub 2017 Dec 14.PMID: 29239119
- Method comparison and validation of a prototype device for measurement of ionized calcium concentrations cow-side against a point-of-care instrument and a benchtop blood-gas analyzer reference method.
Neves RC, Stokol T, Bach KD, McArt JAA.J Dairy Sci. 2018 Feb;101(2):1334-1343. doi: 10.3168/jds.2017-13779. Epub 2017 Dec 14.PMID: 29248221 - Diagnostic performance of cytology for assessment of hepatic lipid content in dairy cattle.
Fry MM, Yao B, Ríos C, Wong C, Mann S, McArt JAA, Nydam DV, Leal Yepes FA, Viesselmann L, Geick A, Goldin K, Jordan A, Behling-Kelly E. J Dairy Sci. 2018 Feb;101(2):1379-1387. doi: 10.3168/jds.2017-12897. Epub 2017 Dec 14.PMID: 29248218