Our lab utilizes a combination of structural biology, biochemistry, and cell biology to dissect the mechanisms of complex molecular machines. Research efforts are divided between two major areas: 1) the structure and function of mechanochemical GTPases and 2) investigating the mechanisms of bacterial defense systems, specifically those targeting modified DNA. Together these endeavors have important implications for human diseases such as centronuclear myopathy, Charcot–Marie–Tooth disease, and cholesterol trafficking disorders and also in the development of new therapeutic strategies for treating antibiotic-resistant bacterial infections in humans and animals. We maintain a collaborative, interdisciplinary approach to science and have partnered with investigators at Cornell and NIH to tackle challenging biological problems.

• Graduate Research (Visiting Student), NIDDK/NIH, LMB, 2009
• PhD, Biophysics, The Scripps Research Institute, 2009
• BS/MS, Biochemistry, Brandeis University, 2003

• 2013-Present, Assistant Professor, Department of Molecular Medicine, College of Veterinary Medicine, Cornell University
• 2009-2013, Postdoctoral Fellow, NIDDK/NIH, LMB

Click here for a complete listing of Dr. Chappie's publications

• 2013, Peter Meinig Family Investigator in the Life Sciences
• 2012, Earl Stadtman Finalist, National Institutes of Health
• 2012, Fellows Award for Research Excellence (FARE), National Institutes of Health
• 2012, NIDDK Fellows Scientific Retreat Travel Award for Outstanding Poster, National Institute of Diabetes and Digestive and Kidney Diseases
• 2011, Fellows Award for Research Excellence (FARE), National Institutes of Health
• 2007-2009, Ruth L. Kirschstein Predoctoral Fellowship, National Institutes of Health
• 2005-2007, Predoctoral Fellowship, American Heart Association
• 2006, Scripps Research Institute Graduate Retreat Biology Poster Award, Scripps Research Institute
• 1999-2003, Justice Brandeis Scholar, Brandeis University
• 2002-2002, Dean's List , Brandeis University
• 2000-2000, Dean's List, Brandeis University
• 1999-1999, Dean's List, Brandeis University

• 2004-2013, American Society for Cell Biology
• 2004-2013, Biophysical Society

PROFESSIONAL SERVICE

• 2009-2013, National Institute of Diabetes and Digestive and Kidney Diseases Fellows Advisory Board, Member