The Lin lab studies the development and regeneration of the nervous system using the mouse olfactory system as a model. During development, billions of neurons must form connections with their appropriate partners in order to form a functional nervous system. Once born, most neurons in the central nervous system cannot be replaced.  While some peripheral neurons can be regenerated, this process is often slow and fraught with error.  In contrast, a signature feature of the olfactory system is its ability to regenerate throughout life. Our lab is interested in studying the molecular mechanisms that underlie this remarkable process.  Our long term goal is to identify fundamental mechanisms in the olfactory system that can be used to augment regeneration throughout the nervous system. 

I teach in the undergraduate, graduate, and veterinary curricula at Cornell.  BioAP 3110, (Principles of Animal Physiology) is an undergraduate course that attracts pre-vet and pre-med students due to its emphasis on understanding fundamental mechanisms of physiology.  BioAP 6100 (By Scientific Design, skill building for a career in the life sciences) is a course for first year graduate students. It focuses on teaching basic principles of grant writing, public presentation, and hypothesis development. Finally, I guest lecture in VTMED 5300 (Function and Dysfunction, part I), which is a team taught course for first year veterinary students.  In this course, I lecture in the introductory neuropharmacology section.

PhD, UC Berkeley
BS, Harvard University

Coming soon

1. Ghazanfar, S., Lin, Y., Su, X., Lin, D.M., Patrick, E., Han, Marioni, J., and Yang, J. Investigating higher order interactions in single cell data with scHOT.  (2020), Nature Methods, 17, 799-806. PMC7610653

2. Bisogni, A.J., Ghazanfar, S., Williams, E.O., Marsh, H., Yang, Y.H., and Lin, D.M. Tuning of delta protocadherin adhesion through combinatorial diversity. eLife (2018) 7 e41050. PMC6326727

3. Martinez, A.P., Chung, A.C., Huang, S., Bisogni, A.J., Lin, Y., Cao, Y., Williams, E.O)., Kim, J.Y., Yang, J.Y.H., and Lin, D.M.  Pcdh19 mediates olfactory sensory neuron coalescence during development and regeneration.  iScience (2023), 26(11): 108220, PMC10641745.

Browse PubMed for a complete listing of Dr. Lin's publications

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