Climate change is directly impacting the landscape of infectious diseases, especially mosquito-borne viruses. Dengue stands as a perfect model system for this phenomenon given the abundance of epidemiological, genetic and vector data. The goals of our project are to (1) define the necessary climate and socio-economic conditions for absent, epidemic or endemic transmission, and (2) predict the real-time expansion of epidemic and endemic transmission due to climate change. We will collaborate with the CDC Puerto Rico branch to help design a step wise holistic program encompassing prevention strategies, targeted flexible surveillance and control measures. This will foster the allocation of important resources, like new vaccines and emerging mosquito control technologies.