We request funds to purchase a new water-bath sonicator that will support research in the majority of faculty groups in the Baker Institute. Uses of a water bath sonicator involve shearing DNA for a variety of genomic and functional analyses, including chromatin immunoprecipitation (ChIP), chromatin run-on and sequencing (ChROseq), hybrid capture sequencing, and genomic DNA fragmentation and sequencing analysis. For sequencing applications requiring a consistent and narrow range of fragment sizes compatible with short-read sequencing platforms, sonication is essential. Since Cornell does not have its own PacBio instrumentation, which is the gold standard for high quality long-read sequencing, most investigators are utilizing short-read chemistry.