The overall goal of this project is to evaluate the efficacy of heat of porcine plasma on the inactivation of viral pathogens. The viral pathogens that will be tested include: porcine epidemic diarrhea virus (PEDV strain CO13), porcine respiratory and reproductive virus (PRRSV strain SD1-7-4), porcine parvovirus (PPV, strain NADL-2) and Senecavirus A (SVA strain SD15-26) and porcine circovirus 2 (PCV2 strain SD). Four of these pathogens (PEDV, PRRSV, PPV and SVA) were tested with the through spray drying, heating of liquid plasma and storage of dried plasma at 20°C for two weeks. PCV2 will be included in this study due to its high prevalence and its known resistance to heat treatment.