Periodontitis is a highly prevalent inflammatory disease that occurs in the domestic cat and other mammals. It is characterized by the destruction of periodontal tissues and is associated with significant morbidity; moreover, it has been implicated with systemic inflammation, diabetes mellitus, obesity, cardiovascular disease, among other serious chronic systemic diseases and conditions. The pathogenesis of periodontitis involves the presence of a complex and dynamic subgingival microenvironment (dental plaque), that elicits an inflammatory response by the host.