A Regenerative Medicine Approach for TMJ Meniscus Restoration: Temporomandibular Joint Meniscus Replacement Joint Meniscus Replacement Pig Model GLP
Principal Investigator: Jonathan Cheetham
Department of Clinical Sciences
Email:
jc485@cornell.edu
Sponsor:
University of Pittsburgh (NIH/NIDCR)
Grant Number:
0022723 (121444-1)
Title:
A Regenerative Medicine Approach for TMJ Meniscus Restoration: Temporomandibular Joint Meniscus Replacement Joint Meniscus Replacement Pig Model GLP
Project Amount:
$146,768
Project Period:
July 2015
to
June 2016
DESCRIPTION (provided by applicant):
The long-term objective of this work is the development of a safe and effective regenerative medicine therapy for replacement of the temporomandibular joint (TMJ) meniscus (disc) with associated protection of the TMJ articulating surfaces. The proposed studies are conceptually based upon the use of an extracellular matrix (ECM) scaffold as an inductive template for in-vivo TMJ disc reconstruction. A porcine model of bilateral TMJ disc removal will be used to investigate the remodeling process.