Yrjö Gröhn
Department of Population Medicine and Diagnostic Sciences
Department of Public & Ecosystem Health
James Law Professor of Epidemiology
Department of Population Medicine and Diagnostic Sciences
Cornell University College of Veterinary Medicine
Ithaca, NY 14853
Department of Public & Ecosystem Health
Cornell University College of Veterinary Medicine
Ithaca, NY 14853
Office: 607.253.4394
Lab: 607.253.3571
Fax: 607.253.3907
Email: ytg1@cornell.edu
Research Interest
Education
- 1973 B.V.M., College of Vet. Med., Helsinki, Finland
- 1977 L.V.M.,(equiv DVM) College of Vet. Med., Helsinki, Finland
- 1980 Food Hygienist, College of Vet Med, Helsinki, Finland
- 1982 M.P.V.M., in Epidemiology, University of California, Davis
- 1983 M.S., in Genetics, University of California, Davis
- 1985 D.V.M. (equiv Ph.D.), in Vet. Med., College of Vet. Med., Helsinki
- 2002 Diplomate ECVPH (European College of Vet. Public Health)
Biography/Professional Experience
- 2001-2002 Acting Chair and 2002-2012 Chair, Dept. of Population Medicine and Diagnostic Sciences, Cornell University
- 1998 -2001 Assoc. Chair, Dept. of Population Medicine and Diagnostic Sciences, Cornell University
- 1993 – 1994 and 1995 - 2001 Chief, Section of Epidemiology, Cornell University, Ithaca, NY
- 1994 - 1995 Visiting Professor, F.C. Donders Chair, University of Utrecht, Utrecht, The Netherlands
- 1988 - Present Assistant, Associate, Full, and James Law Professor of Epidemiology, CVM, Cornell University
- 1993 - Present Docent of Epidemiology, University of Helsinki, Finland
- 1988 - 1991 Associate Professor, Dept. of Animal Hygiene, CVM, Helsinki, Finland
- 1986 - 1988 Post doc, Visiting Assistant Professor, Dept. of Clinical Sciences, CVM, Cornell University
Publications
Google Scholar: https://scholar.google.com/citations?user=kh950kkAAAAJ&hl=en
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/?term=grohn+Y
Perspective
- Evans, T.S., et al.: Synergistic China-US ecological research is essential for global emerging infectious disease preparedness. EcoHealth. https://doi.org/10.1007/s10393-020-01471-2
- Søgaard Jørgensen, P. et al.: Co-evolutionary governance of antibiotic and pesticide resistance. Trends in Ecology and Evolution. https://doi.org/10.1016/j.tree.2020.01.011
- Lhermie, G., et al.: Global resistance to antimicrobials and their sustainable use in agriculture. The Lancet Planetary Health. https://doi.org/10.1016/S2542-5196(18)30251-1
- Søgaard Jørgensen, P., et al.: Promoting antibiotic and pesticide susceptibility to preserve an Anthropocene operating space. Nature Sustainability 2018; 1: 632–641 https://doi.org/10.1038/s41893-018-0164-3
- Gröhn, Y.T.et al.: A proposed analytic framework for determining the impact of an antimicrobial resistance intervention at the national level. Animal Health Res Rev. 2017;18(1):1-25. https://pubmed.ncbi.nlm.nih.gov/28506325/
- Gröhn, Y.T.: Progression to multi-scale models and the application to food system intervention strategies. Prev. Vet. Med. 2015, 118: 238-246. https://www.sciencedirect.com/science/article/pii/S0167587714002657?via%3Dihub
- Lanzas, C., et al.: Model or meal? Animal agriculture systems as models for infectious diseases of humans. Nature Reviews, Microbiology. 2010, 8: 139-148. https://www.nature.com/articles/nrmicro2268
Mathematical Modeling
- Eberl, H.J., Gaebler, H.J., Gröhn Y.T.: A brief note on a multistrain SIR model with complete cross-protection and nonlinear force of infection. Communications in Nonlinear Science and Numerical Simulation. DOI: 10.1016/j.cnsns.2021.106001
- Nigsh, A., Robbe-Austerman, S., Stuber, T.P., Pavinski Bitar, P.D., Gröhn Y.T., Schukken, Y.H.: Who infects Whom? - Reconstructing infection chains of Mycobacterium avium ssp. paratuberculosis in an endemically infected dairy herd by use of genomic data. PLOS ONE, 2021 https://doi.org/10.1371/journal.pone.0246983
- Cazer, C.L., Westblade, L.F., Simon, M.S., Magleby, R., Castanheira, M., Booth, J.G., Jenkins, S.G., Gröhn, Y.T.: Analysis of multidrug resistance in Staphylococcus aureus with a machine learning generated antibiogram for Antimicrobial Agents and Chemotherapy AAC02132-20R1 – Chosen Editor’s Pick
- Ceres, K.M., Schukken, Y.H., Gröhn Y.T.: Characterizing infectious disease progression through discrete states using Hidden Markov models. PLoS One. 2020 Nov 20;15(11):e0242683. doi: 10.1371/journal.pone.0242683. eCollection 2020.
- Stapleton, S, Casey CL, Grohn, Y.T.: Modeling the Effect of Tylosin on Macrolide-Resistant Enterococci in Feedlots and Reducing Resistance Transmission. Foodborne Pathogen and Disease 2 Oct 2020 https://doi.org/10.1089/fpd.2020.2835
- Cazer, C. L., M. A. Al-Mamun, K. Kaniyamattam, W. J. Love, J. G. Booth, C. L. Lanzas, and Y. T. Gröhn: Shared multidrug resistance patterns in chicken-associated Escherichia coli identified by association rule mining. Front. Microbiol., Section Antimicrobials, Resistance and Chemotherapy.12 April 2019. https://doi.org/10.3389/fmicb.2019.00687
- Al-Mamun, M.A., Smith, R.L., and Schukken, Y.H., Nigsch, A., Grohn, Y.T.: A data-driven individual-based model of infectious disease in livestock operation: A validation study for Paratuberculosis. PloS One 2018 13(12): e0203177. https://doi.org/10.1371/journal.pone.0203177
- Zoellner, C., Abdullah Al-Mamun, M., Gröhn, Y.T., Jackson, P., Worobo R.W.: Post-harvest supply chain with microbial travelers: a farm-to-retail microbial simulation and visualization framework. Applied and Environmental Microbiology. 2018 Jun 29. DOI: https://aem.asm.org/content/aem/84/17/e00813-18.full.pdf
- Cazer CL, Volkova VV, and Gröhn, Y.T.: Expanding behavior pattern sensitivity analysis with model selection and survival analysis. Cazer et al. BMC Veterinary Research 2018 14:355 https://doi.org/10.1186/s12917-018-0174-y
- Verteramo Chiu, L.J., Tauer, L.W., Al-Mamun, M. A., Kaniyamattam, K., Smith, R.L., Grohn, Y.T.: An agent-based model evaluation of economic control strategies for paratuberculosis in a dairy herd. J. Dairy Sci., 2018, 101(7):6443-6454. DOI: 10.3168/jds.2017-13175
- Al-Mamun, M.A., Smith, R.L., Schukken, Y.H., Gröhn, Y.T.: Use of an individual-based model to control transmission pathways of Mycobacterium avium Subsp. paratuberculosis infection in cattle herds. Scientific reports. 2017; 7(1):11845. DOI: 10.1038/s41598-017-12078-z
- Cazer, C.L., Ducrot, L., Volkova, V.V., Gröhn, Y.T.: Monte Carlo simulations suggest current chlortetracycline drug-residue based withdrawal periods would not control antimicrobial resistance dissemination from feedlot to slaughterhouse. Frontiers in microbiology, 2017, 8:1753. DOI: 10.3389/fmicb.2017.01753
- Volkova VV, Cazer CL, Grohn, Y.T.: Models of antimicrobial pressure on intestinal bacteria of the treated host populations. Epidemiol Infect., 2017, 145(10):2081-2094. DOI: 10.1017/S095026881700084X
- Smith, R.L., Al-Mamun, M.A., Gröhn, Y.T.: Economic consequences of paratuberculosis control in dairy cattle: a stochastic modeling study Prev. Vet. Med. 2017, 138: 17-27. doi: 10.1016/j.prevetmed.2017.01.007
- Al-Mamun, M.A., Smith, R.L., Schukken, Y.H., Gröhn, Y.T.: Modeling of Mycobacterium avium subsp. paratuberculosis dynamics in a dairy Herd: an individual based approach. Journal of Theoretical Biology 2016 Nov 7; 408:105-17. doi: 10.1016/j.jtbi.2016.08.014. Epub 2016 Aug 10.
- Love, W. J., Zawack, K.A., Booth J.G., Gröhn, Y.T., Lanzas C.: Markov networks of collateral antibiotic resistance: National Antimicrobial Resistance Monitoring System surveillance results from E. coli isolates, 2004-2013. PLoS Comput Biol 12(11): e1005160.doi:10.1371/journal. pcbi.1005160
- Smith, R.L., Schukken, Y.H., Gröhn, Y.T.: A new compartmental model of Mycobacterium avium subsp. paratuberculosis infection dynamics in cattle. Prev Vet Med., 2015, 122(3):298-305. DOI: 10.1016/j.prevetmed.2015.10.008
- Smith, R.L., Gröhn, Y.T.: Use of approximate Bayesian computation to assess and fit models of Mycobacterium leprae to predict outcomes of the Brazilian control program. PLoS One., 2015, 10(6):e0129535. DOI: 10.1371/journal.pone.0129535
Optimizing Health and Management
- Verteramo Chiu, L.J., Tauer, L.W., Lhermie. G., Kaniyamattam, K., Gröhn Y.T.: Benefits of Preconditioning Cattle under Stochastic Feedlot Performance. Journal of Agricultural and Applied Economics. (2022), 1–18 doi:10.1017/aae.2022.32
- Ceres, K.M., Stanhope, M.J., Gröhn Y.T.: A critical evaluation of Mycobacterium bovis pangenomics, with reference to its utility in outbreak investigation. Microbial Genomics 2022 Volume 8, Issue 6 Published: 28 June 2022 https://doi.org/10.1099/mgen.0.000839
- Verteramo Chiu, L.J., Tauer, L. W., Gröhn Y.T.: Pricing efficiency in livestock auction markets: A two-tier frontier approach. Agricultural Economics, 1-13, 2022. https://doi.org/10.1111/agec. 12735
- Kaniyamattam, K, Hertl, J., Tauer, L. W., and Gröhn, Y.T.: Economics of reducing antibiotic usage for pathogen-specific clinical mastitis through genomic selection and disease management. Pre. Vet. Med. 2022 Apr 6;204:105642. https://doi.org/10.1016/j.prevetmed.2022.105642
- Kaniyamattam, K., Tauer, L. W., Gröhn, Y.T.: System economic costs of antibiotic use elimination in the US beef supply chain. Front. Vet. Sci. doi: 10.3389/fvets.2021.606810
- Verteramo Chiu, L.J., Tauer, L.W., Smith, R.L., Gröhn Y.T.: Economic Effects of a Potential Foodborne Disease: Potential Relationship between Mycobacterium avium subs. paratuberculosis in Dairy and Crohn’s in Humans" Int. J. Food System Dynamics 11 (5), 2020, 482-502. DOI: http://dx.doi.org/10.18461/ijfsd.v11i5.69
- Lhermie G, Sauvage. P., Tauers, L.W., Verteramo Chiu, L., Kanyiamattam, K., Raboisson, D., Ferchiou, A., Scott, H. M, Smith, D.R., Grohn, Y.T.: Economic effects of policy options restricting antimicrobial use for high risk cattle placed in U.S. feedlots. PLOS ONE https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239135
- K. Kaniyamattam, J. A. Hertl, G. Lhermie, U. Tasch, R. Dyer, and Gröhn, Y.T.: Cost benefit analysis of automatic lameness detection systems in dairy herds: A dynamic programming approach. Pre. Vet. Med. 178:104993 10.1016/j.prevetmed.2020.104993
- Verteramo Chiu, L.J., Tauer, L.W., Gröhn, Y.T., and Smith, R. L.: Ranking disease control strategies with stochastic outcomes. Pre. Vet. Med. 2020, 176, 104906 (Editor's Choice February 2020) https://doi.org/10.1016/j.prevetmed.2020.104906
- Lhermie, G., Grohn, Y.T., Serrand, T., Sans, P., Raboisson, D.: How do veterinarians influence sales of antimicrobials? A spatial-temporal analysis of the French prescribing-delivery complex in cattle. The Zoonoses and Public Health. ZPH December 23, 2019 DOI: 10.1111/zph.12678 PMID: 31868302
- Verteramo Chiu L.J., Tauer L.W., Gröhn Y.T., Smith R.L. (2019). Mastitis risk effect on the economic consequences of paratuberculosis control in dairy cattle: A stochastic modeling study. PLOS ONE 14(9): e0217888. https://doi.org/10.1371/journal.pone.0217888
- Kaniyamattam, K., A. De Vries, L. W. Tauer, and Gröhn, Y.T.: Economics of reducing antibiotic usage for clinical mastitis and metritis through genetic selection. J. Dairy Sci. 2020 Jan;103(1):473-491. doi: 10.3168/jds.2018-15817
- Salvador L.C.M., O’Brien D.J., Cosgrove M.K., Stuber T. P., Schooley A., Crispell J., Church S., Grohn Y.T., Robbe-Austerman S., Kao R.R.: Disease management at the wildlife-livestock interface: using whole-genome sequencing to study the role of elk in Mycobacterium bovis transmission in Michigan, USA. Mol Ecol. 2019; 28: 2192– 2205. https://doi.org/10.1111/mec.15061
- Lhermie, G., Wernlii, D., Søgaard Jørgensen, P., Kenkel, D., Lin Lawell, C.-Y. C., Tauer, L.W., Gröhn, Y.T.: Tradeoffs between resistance to antimicrobials in public health and their use in agriculture: moving towards sustainability assessment. Ecological Economics. https://doi.org/10.1016/j.ecolecon.2019.106427
- Lhermie. G., Verteramo, L.C., Kaniyamattam, K., Tauer L.W., Scott, H.M., Gröhn, Y.T.: Antibiotic policies in United States beef production: choosing the right instruments to reduce antimicrobial resistance under structural and market constraints. Front. Vet. Sci., 19 July 2019 https://doi.org/10.3389/fvets.2019.00245
- Verteramo Chiu, L.J., Tauer, L.W., Smith, R.L., Gröhn Y.T.: Assessment of the bovine tuberculosis elimination protocol in the United States. J. Dairy Sci. 2019, 102:1-17. https://doi.org/10.3168/jds.2018-14990
- Lhermie, G., L.W. Tauer, Grohn, Y.T.: An assessment of the economic costs to the U.S. dairy market of antimicrobial use restrictions. Preventive Veterinary Medicine 2018. Volume 160, Pages 63-67. https://doi.org/10.1016/j.prevetmed.2018.09.028
- Lhermie, G., Tauer, L.W., Gröhn, Y.T.: The farm cost of decreasing antimicrobials use in dairy production. PLoS ONE, 2018, 13(3): e0194832. DOI: 10.1371/journal.pone.0194832
- Troendle, J.A., Tauer, L.W., Gröhn, Y.T.: Optimally achieving milk bulk tank somatic cell count thresholds, Journal of Dairy Science. 2017. 100: 731-738. https://doi.org/10.3168/jds.2016-11578
- Lhermie, G., Gröhn, Y.T., Raboisson, D.: Addressing antimicrobial resistance: an overview of priority actions to prevent suboptimal antimicrobial use in food-animal production. Front. Microbiol., 06 January 2017 https://doi.org/10.3389/fmicb.2016.02114
Mathematical modeling of infectious diseases with application to COVID-19.
Three virtual lectures by the Epidemiology Faculty at College of Veterinary Medicine, Cornell University, April 2020.
Session 1 recording: Modeling basics: SIR, R0 and Herd Immunity, some example models including COVID-19. (Yrjo Grohn);
Session 2 recording: Why are all COVID-19 models wrong but some are useful? (Renata Ivanek); “Covid Act Now” (Renata Ivanek); Early dynamics of transmission and control of COVID-19: a mathematical modelling study (Wendy Beauvais);
Session 3 recording: Prediction of hospital demand from the COVID-19 death curve: IHME Model (Casey Cazer); Molecular epidemiology of SARS-Cov-2: what viral genomes can tell us about transmission? (Kristina Ceres).
https://vod.video.cornell.edu/channel/Mathematical%2BModeling%2Bof%2BInfectious%2BDiseases/160460891
Awards and Honors
- 1981-1982 Kellogg Fellow
- Phi Zeta, Veterinary Medicine
- Sigma Xi, American Research Association
- Gamma Sigma Delta, The Honor Society of Agriculture
- 1994-1995 F.C. Donders Chair, University of Utrecht, August, 1994 - July, 1995
- 1999 Samuel F. Scheidy Memorial Award
- 2007 The Gareth Davies lecture
- 2013 The Calvin Schwabe Award for Lifetime Achievement
- 2014 UC Davis School of Veterinary Medicine Alumni Achievement Award
- 2014 James Law Professor; Cornell Institute for Food Systems Fellow; Atkinson Center for a Sustainable Future Faculty Fellow
- The American Veterinary Epidemiology Society Honorary Diplomate, 2019
- SUNY the Chancellor’s Award for Excellence in Scholarship and Creative Activity, 2021-22
- The AVMA Lifetime Excellence in Research Award, 2022
Professional/Academic Affiliations
- American Dairy Science Association
- American Veterinary Medical Association
- Association of Teachers of Veterinary Public Health and Preventive Medicine
- Finnish Veterinary Medical Association
- New York State Veterinary Medical Society
- Nordic Association of Veterinary Epidemiology
- System Dynamics Society