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Bettina Wagner

Faculty member

Department of Population Medicine and Diagnostic Sciences

James Law Professor of Immunology

WAGNER LAB

Department of Population Medicine and Diagnostic Sciences
Cornell University College of Veterinary Medicine
Ithaca, NY 14853


Email: bw73@cornell.edu 

Research Interest

My laboratory focuses on research in equine immunology. We are particularly interested in immune responses and protective mechanisms in neonates and young foals. The disease models include intracellular pathogens, such as Equine herpesvirus type 1 (EHV-1), and allergic diseases especially Culicoides induced skin hypersensitivity. Major pathways that are investigated by my group are adaptive T-cell immunity, antibody isotype responses and cytokine regulation pathways. Another major goal is the development of new immune reagents for horses and advanced technologies in veterinary diagnostics, such as multiplex assays for infectious diseases, cytokines and immunoglobulin isotypes.

Education

  • DVM - 1990 Veterinary Medicine - School of Veterinary Medicine, Hannover, Germany
  • Dr.vet.med - 1993 Veterinary Immunology - School of Veterinary Medicine, Hannover, Germany
  • Postdoctoral fellow - 1994 Genetics: Isolation and characterization of IGHC genes of the horse - Institute for Genetics, University of Cologne, Germany
  • Habilitation - 2006 Immunology - School of Veterinary Medicine, Hannover, Germany

Biography/Professional Experience

•    1991-1993 Post-DVM fellow, Dr. med. vet.-candidate, title of the dissertation:“Investigation of the equine immunoglobulin system: Generation and characterization of monoclonal immunoglobulins and initial molecular analysis of genes encoding immunoglobulin heavy chains” Immunology Unit, School of Veterinary Medicine, Hannover, Germany

•    1993-1994 Post-doctoral fellow, Institute for Genetics, University of Cologne, Germany

•    1994-2002 Research Associate and Lecturer, School of Veterinary Medicine, Hannover, Germany

•    2002-2004 Visiting Scientist, Baker Institute for Animal Health, College of Veterinary Medicine, and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA

•    2004-2006 Senior Research Associate, Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

•    2006-2010 Assistant Professor, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

•    2006-present Director of Serology/Immunology, Animal Health Diagnostic Center, Cornell University, Ithaca, NY, USA

•    2010-2016 Associate Professor, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

•    2014-present Associate Dean for Research and Graduate Education, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

•    2016-present Professor, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

Publications

  1. Wagner B, Radbruch A, Richards C and Leibold W. 1995. Monoclonal equine IgM and IgG immunoglobulins. Vet. Immunol. Immunopathol., 47: 1-12.
  2. Wagner B, Brandt K, Sheoran A, Holmes MA, Deegen E and Leibold W. 1997.Immunoglobulin isotypes in the vitreous of horses with and without recurrent uveitis. Dtsch. tierärztl. Wschr., 104: 467-470.
  3. Wagner B, Siebenkotten G, Leibold W and Radbruch A. 1997. Organization of the equine immunoglobulin constant heavy chain genes. I. cε and cα genes. Vet. Immunol. Immunopathol., 60: 1 - 13.
  4. Wagner B, Overesch G, Sheoran AS, Holmes MA, Richards C, Leibold W and Radbruch A. 1998. Organization of the equine immunoglobulin heavy chain constant region genes. III. Alignment of cµ, cγ, cε and cα genes. Immunobiol., 199: 105-119.
  5. Overesch G, Wagner B, Radbruch A and Leibold W. 1998. Organization of the equine immunoglobulin constant heavy chain genes.II. Equine cγ genes. Vet. Immunol. Immunopathol., 66: 273-287.
  6. Eule JC, Wagner B, Leibold W und Deegen E. 2000. Occurrence of different immunoglobulin isotypes in horses with equine recurrent uveitis (ERU). Berl. Münch. Tierärztl. Wschr., 113: 253-257.
  7. Dohmann K, Wagner B, Horohov DW and Leibold W. 2000. Expression and characterisation of equine interleukin 2 and interleukin 4. Vet. Immunol. Immunopathol., 77: 243-256.
  8. Wagner B, Siebenkotten G, Radbruch A and Leibold W. 2001..Nucleotide sequence and restriction fragment length polymorphisms of the equine Cε gene. Vet. Immunol. Immunopathol., 82: 193-202.
  9. Steinbach F, Deeg C, Mauel S and Wagner B. 2002. Equine immunology: offspring of the serum horse. Trends in Immunol., 23: 223-225.
  10. Wagner B, Greiser-Wilke I, Wege A, Radbruch A and Leibold W. 2002. Evolution of the six equine IGHG genes and corresponding immunoglobulin gamma heavy chains. Immunogenetics, 54: 353-364.
  11. Wagner B, Siebenkotten G, Leibold W and Radbruch A. 2002. Expression of a 4-(Hydroxy-3nitro-phenyl) acetyl (NP) specific equi-murine IgE antibody that mediates histamine release in vitro and a type I skin reaction in vivo. Equine Vet. J., 34: 657-665.
  12. Grummer B, Bendfeldt S, Wagner B and Greiser-Wilke I. 2002. Induction of the intrinsic apoptotic pathway in cells infected with cytopathic bovine virus diarrhoea virus. Virus Research, 90: 143-153.
  13. Wagner B, Radbruch A, Rohwer J and Leibold W. 2003. Monoclonal anti-equine IgE antibodies with specificity for different epitopes on the immunoglobulin heavy chain of native IgE. Vet. Immunol. Immunopathol., 92: 45-60.
  14. Wagner B, Greiser-Wilke I and Antczak DF. 2003. Characterization of the horse (Equus caballus) IGHA gene. Immunogenetics, 55: 552-560.
  15. Ainsworth DM, Grunig G, Matychak MB, Young J, Wagner B, Erb HN and Antczak DF. 2003. Recurrent airway obstruction (RAO) in horses is characterized by INF-g and IL-8 production in bronchoalveolarlavage cells. Vet. Immunol. Immunopathol., 96: 83-91.
  16. Wagner B, Miller DC, Lear TL and Antczak DF. 2004. The complete map of the Ig heavy chain constant gene region reveals evidence for seven IgG isotypes and for IgD in the horse. J. Immunol., 173: 3230-3242.
  17. Desjardins I, Théoret C, Joubert P, Wagner B and Lavoie J-P. 2004. Comparison of TGF-beta 1 concentrations in bronchoalveolar fluid of horses affected with heaves and of normal controls. Vet. Immunol. Immunopathol.,101: 133-141.
  18. Scharsack JP, Steinhagen D, Körting W, Wagner B, Leibold W, Schuberth HJ. 2004. Some immune parameters in carp cyprinus Carpio susceptible and resistant to the haemoflagellate Trypanoplasma borreli. Dis. Aquat. Organ., 60: 41-48.
  19. Xu J, Lasry J.B, Svaren J, Wagner B and Darien BJ. 2005. Identification of equine P-selectin glycoprotein ligend-1 (CD162). Mamm. Genome, 16: 66-71.
  20. Wagner B, Robeson J, McCracken M, Wattrang E and Antczak DF. 2005. Horse cytokine/IgG1 fusion proteins – mammalian expression of biologically active cytokines and a system to verify antibody specificity to equine cytokines. Vet. Immunol. Immunopathol.,105: 1-14.
  21. Wagner B. 2006. Immunoglobulins and immunoglobulin genes of the horse. Dev. Comp. Immunol., 30: 155-164.
  22. Wagner B, Flaminio JBF, Hillegas J, Leibold W, Erb HN and Antczak DF. 2006. Occurrence of IgE in foals: evidence for transfer of maternal IgE by the colostrum and late onset of endogenous IgE production in the horse. Vet. Immunol. Immunopathol.,110: 269-278.
  23. Wagner B, Hillegas JM and Antczak DF. 2006. A monoclonal antibody to equine interleukin 4. Vet. Immunol. Immunopathol., 110: 363-367.
  24. Ainsworth DM, Wagner B, Franchini M, Grunig G, Erb HN and Tan J-Y.2006.Time-dependent alterations ininterleukin-8 gene expression in the bronchial epithelium ofhorses with recurrent airway obstruction (RAO).Am. J. Vet. Res., 67: 669-677.
  25. Goodman LB, Wagner B, Flaminio MJ, Sussman KH, Metzger SM, Holland R and Osterrieder N. 2006.Comparison of the efficacy of inactivated combination and modified-live virus vaccines against challenge infection with neuropathogenic equine herpesvirus type 1 (EHV-1). Vaccine, 24: 3636-3645.
  26. Wagner B, Miller WH, Morgan EE, Hillegas JM, Erb HN, Leibold W and Antczak DF. 2006. IgE and IgG antibodies in skin allergy of the horse. Vet. Res.,37: 813-825.
  27. Rosas CT, Tischer BK, Perkins GA, Wagner B, Goodman LB and Osterrieder N. 2007. Liveattenuated recombinant equine herpesvirus type 1 (EHV-1) induces a neutralizing antibody response against West Nile virus (WNV). Virus Res.,125:69-78.
  28. Xu J, Cai J, Anderson B, Wagner B, Albrecht R, Peek S, Suresh M and Darien BJ. 2007. Cloning and functional characterization of recombinant equine P-selectin. Vet. Immunol. Immunopathol., 116: 115-130.
  29. Morgan EE, Miller WH and Wagner B. 2007. A comparison of intradermal testing and detection of allergen-specific immunoglobulin E in serum by enzyme-linked immunosorbent assay in horses affected with skin hypersensitivity. Vet. Immunol. Immunopathol., 120: 160-167.
  30. Ainsworth DM, Wagner B, Erb HN, Young JC and Retallick DE. 2007.  Effects of in vitro exposure to hay dust on expression of interleukin-17, -23,-8, and -1b and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells isolated from horses chronically affected with recurrent airway disease. Am. J. Vet. Res., 68: 1361-1369.
  31. Lewis MJ, Wagner B and Woof JM. 2008. Different effector function capabilities of seven equine IgG subclasses have implications for vaccine strategies. Mol. Immunol., 45: 818-827.
  32. Wagner B, Glaser A, Hillegas JM, Erb HN, Gold C and Freer H. 2008. Monoclonal antibodies to equine IgM improve the sensitivity of West Nile virus-specific IgM detection in horses. Vet. Immunol. Immunopathol.,122: 46-56.
  33. Wagner B, Hillegas JM, Brinker DR, Horohov DW and Antczak DF. 2008. Characterization of monoclonal antibodies to equine interleukin-10 and detection of T regulatory 1 cells in horses. Vet. Immunol. Immunopathol.,122: 57-64.
  34. Hamza E, Wagner B, Jungi TW, Mirkovitch J and Marti E. 2008. Reduced incidence of insectbite hypersensitivity in Icelandic horses is associated with a down-regulation of interleukin-4 by interleukin-10 and transforming growth factor-β1.Vet. ImmunolImmunopathol.,122: 65-75.
  35. Wagner B, Hillegas JM, Flaminio MJBF and Wattrang E. 2008. Monoclonal antibodies to equine interferon-α (IFN-α): New tools to neutralize IFN activity and to detect secreted IFN-α. Vet. Immunol. Immunopathol., 125: 315-325.
  36. Perkins GA, Viel L, Wagner B, Hoffman A, Erb HN and Ainsworth DM. 2008. Histamine bronchoprovocation does not affect bronchoalveolar lavage fluid cytology, gene expression and protein concentrations of IL-4, IL-8 and IFN-γ. Vet. Immunol. Immunopathol.,126: 230-235.
  37. Wagner B, Childs BA and Erb HN.2008. A histamine release assay to identify sensitization to Culicoides allergens in horses with skin hypersensitivity. Vet. Immunol. Immunopathol., 126: 302-308.
  38. Marti E, Gerber V, Wilson AD, Lavoie JP, Horohov D, Crameri R, Lunn P, Antczak D, Björnsdottir S, Björnsdottir TS, Cunningham F, Derer M, Frey E, Hamza P, Horin P, Heimann M, Kolm-Stark G, Olafsdottir G, Ramery E, Russell C, Schaffartzik A, Svansson V, Torsteinsdottir S and Wagner B. 2008. Report of the 3rdHavemeyer Workshop on Allergic Diseases of the Horse, Iceland, June 2007. Vet. Immunol. Immunopathol., 126: 351-361.
  39. Wagner B and Freer H. 2009. Development of a bead-based multiplex assay for simultaneous quantification of cytokines in horses. Vet. Immunol. Immunopathol., 127: 242-248.
  40. Mealey RH, Leib SR, Littke MH, Wagner B, Horohov DW and McGuire TC. 2009. Viral load and clinical disease enhancement associated with a lentivirus cytotoxic T lymphocyte vaccine regimen. Vaccine, 27: 2453-2468.
  41. Garner CD, Antonopoulos DA, Wagner B, Duhamel GE, Keresztes I, Ross DA, Young VB and Altier C. 2009. Perturbation of the small intestinal microbial ecology by streptomycin alters pathology in a Salmonella enteric serovar Typhimurium murine model of infection. Infect.Immun.,77: 2691-2702.
  42. Reyner CL, Wagner B, Young JC and Ainsworth DM. 2009. Effects of in vitro exposure to hay dust on expression of interleukin-23, -17, -8, -1β, and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells isolated from horses acutely affected with recurrent airway disease (RAO). Am. J. Vet. Res., 70: 1277-1283.
  43. Wagner B. 2009. IgE in horses: Occurrence in health and disease. Vet. Immunol. Immunopathol., 132: 21-30.
  44. Wagner B, Miller WH, Erb HN, Lunn DP, Antczak DF. 2009. Sensitization of skin mast cells with IgE antibodies to Culicoides allergens occurs frequently in clinically healthy horses. Vet. Immunol. Immunopathol.,132: 53-61.
  45. Burton AB, Wagner B, Erb HN and Ainsworth DM. 2009. Serum interleukin-6 (IL-6) and IL10 concentrations in normal and septic neonatal foals. Vet. Immunol. Immunopathol., 132: 122128.
  46. Hamza E, Torsteinsdottir S, Eydal M, Frey CF, Mirkovitch J, Brcic M, Wagner B, Wilson AD, Jungi TW, Marti E. 2009. Increased IL-4 and decreased regulatory cytokine production following relocation of Icelandic horses from a high to low endoparasite environment. Vet. Immunol. Immunopathol.,133: 40-50.
  47. Mestre A, Noronha L, Wagner B and Antczak D. 2010. Split immunological tolerance to trophoblast. Int. J. Dev. Biol., 54: 445-455.
  48. Wagner B, Stokol T and Ainsworth DM. 2010. Induction of interleukin-4 production in neonatal IgE+ cells after crosslinking of maternal IgE. Dev. Comp. Immunol.,34: 436-444.
  49. Wagner B, Burton A and Ainsworth DM. 2010. Interferon-gamma, interleukin-4 and interleukin-10 production by T helper cells reveals intact Th1 and regulatory TR1 cell activation and a delay of the Th2 cell response in equine neonates and foals. Vet. Res., 41(4): 47.
  50. Goehring LS, Wagner B, Bigbie R, Hussey SB, Rao S, Morley PS, Lunn DP. 2010. Control of EHV-1 viremia and nasal shedding by commercial vaccines. Vaccine, 28: 5203-5211.
  51. Kabithe E, Hillegas J, Stokol T, Moore J, Wagner B. 2010. Monoclonal antibodies to equine CD14. Vet. Immunol. Immunopathol., 138: 149-153.
  52. Lewis MJ, Wagner B, Irvine R, Woof JM. 2010. IgA in the horse: cloning of equine polymeric Ig receptor and J chain and characterisation of recombinant forms of equine IgA. Mucosal Immunol.,3: 610-621.
  53. Soboll Hussey G, Hussey SB, Wagner B, Horohov DW, Van de Walle GR, Osterrieder N, Goehring LS, Rao S, Lunn DP. 2011. Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant. Vet. Res. 42:23.
  54. Robbin MG, Wagner B, Noronha LE, Antczak DF, deMestre AM. 2011. Subpopulations of equine blood lymphocytes expressing regulatory T cell markers. Vet. Immunol. Immunopathol., 140: 90-101.
  55. Wagner B, Freer H, Rollins A, Erb HN. 2011. A fluorescent bead-based multiplex assay for the simultaneous detection of antibodies to B. burgdorferi outer surface proteins in canine serum. Vet. Immunol. Immunopathol., 140: 190-198.
  56. Wimer CL, Damiani A, Osterrieder N, Wagner B. 2011. Equine herpesvirus type-1 modulates CCL2, CCL3, CCL5, CXCL9, and CXCL10 chemokine expression. Vet. Immunol. Immunopathol., 140: 266-274.
  57. Lee SH, Lillehoj HS, Park MS, Baldwin C, Tompkins D, Wagner B, Babu U, Cacho ED, Min W. 2011. Development and characterization of mouse monoclonal antibodies reactive with chicken CD80. Comp. Microbiol. Immunol. Infect. Dis., 34: 273-279.
  58. Wagner B, Wimer C, Freer H, Osterrieder N, Erb HN. 2011. Infection of peripheral blood mononuclear cells with neuropathogenic equine herpesvirus type-1 strain Ab4 reveals intact interferon-α induction and induces suppression of anti-inflammatory interleukin-10 responses in comparison to other viral strains. Vet. Immunol. Immunopathol., 143: 116-124.
  59. Lee SH, Lillehoj HS, Jang SI, Baldwin C, Tompkins D, Wagner B, Parcells M, Cacho ED, Hong YH, Min W, Lillehoj EP. 2011. Development and characterization of mouse monoclonal antibodies reactive with chicken interleukin-2 receptor alpha chain (CD25). Vet. Immunol. Immunopathol., 144: 396-404.
  60. Wagner B, Freer H, Rollins A, Erb HN, Lu Z, Gröhn Y. 2011. Development of a multiplex assay for detection of antibodies to Borrelia burgdorferi in horses and its validation using Bayesian and conventional statistical methods. Vet. Immunol. Immunopathol., 144: 374-381.
  61. Mealey RH, Ueti MW, Kappmeyer LS, Wagner B, Knowles DP. 2012. Protective effects of passively transferred merozoite-specific antibodies against Theileria equi in horses with severe combined immunodeficiency. Clin. Vacc. Immunol., 19: 100-104.
  62. Goodman LB, Wimer C, Dubovi E.J, Gold C, Wagner B. 2012. Immunological correlates of vaccination and infection for equine herpesvirus type 1. Clin. Vacc. Immunol., 19: 235-241.
  63. Lee SH, Lillehoj HS, Jang SI, Lee KW, Baldwin C, Tompkins D, Wagner B, Del Cacho E, Lillehoj EP. 2012. Development and Characterization of Mouse Monoclonal Antibodies Reactive with Chicken CD83. Vet. Immunol. Immunopathol., 145: 527-533.
  64. Wagner B, Freer H, Rollins A, Garcia-Tapia D, Erb HN, Earnhart C, Marconi R, Meeus P. 2012. Antibodies to Borrelia burgdorferi OspA, OspC, OspF and C6 antigens as markers for early and late infection in dogs. Clin. Vacc. Immunol., 19: 527-535.
  65. Wattrang E, Palm AK, Wagner B. 2012. Cytokine production and proliferation upon in vitro oligodeoxyribonucleotide stimulation of equine peripheral blood mononuclear cells. Vet. Immunol. Immunopathol., 146: 113-124.
  66. Wagner B, Hillegas J, Babasyan S. 2012. Monoclonal antibodies to equine CD23 identify the low-affinity receptor for IgE on subpopulations of IgM+ and IgG1+ B-cells in horses. Vet. Immunol. Immunopathol., 146: 125-134.
  67. Noronha LE, Harman RM, Wagner B, Antczak DF. 2012. Generation and characterization of monoclonal antibodies to equine CD16. Vet. Immunol. Immunopathol., 146: 135-142.
  68. Priest HL, Irby NL, Schlafer DH, Divers TJ, Wagner B, Glaser AL, Chang YF, Smith MC. 2012. Diagnosis of Borrelia-associated uveitis in two horses. Vet. Ophthalmol., 15: 398-405.
  69. Noronha LE, Harman RM, Wagner B, Antczak DF. 2012. Generation and characterization of monoclonal antibodies to equine NKp46. Vet. Immunol. Immunopathol., 147: 60-68.
  70. Kydd JH, Slater J, Osterrieder N, Lunn DP, Antczak DF, Azab W, Balasuriya U, Barnett C,Brosnahan M, Cook C, Damiani A, Elton D, Frampton A, Gilkerson J, Goehring L, Horohov D,Maxwell L, Minke J; Morley P, Nauwynck H, Newton R, Perkins G, Pusterla N, Soboll-Hussey G, Traub-Dargatz J, Townsend H, Van de Walle GR, Wagner B. 2012. Third International Havemeyer Workshop on Equine Herpesvirus Type 1 (EHV-1); Home Ranch, Clarke, Steam Boat Springs, Colorado, USA; 19th-22nd September 2011. Equine Vet. J., 44: 513-517.
  71. Bresgen C, Lämmer M, Wagner B, Osterrieder N, Damiani A. 2012. Serological Responses and Clinical Outcome after Vaccination of Mares and Foals with Equine Herpesvirus Type 1 and 4 (EHV-1 and EHV-4) Vaccines. Vet. Microbiol., 160: 9-16.
  72. Wagner B, Erb HN. 2012. Dogs and horses with antibodies to outer-surface protein C as ontime sentinels for ticks infected with Borrelia burgdorferi in New York State in 2011. J. Prevent. Vet. Med., 107: 275-279.
  73. Van der Meide NMA, Meulenbroeks C, van Altena C, Schurink A, Ducro B, Wagner B, Leibold W, Rohwer J, Jacobs F, Sloet van Oldruitenborgh-Oosterbaan MM, Savelkoul HFJ, Tijhaar E. 2012. Culicoides obsoletus extract relevant for diagnostics of insect bite hypersensitivity in horses. Vet. Immunol. Immunopathol., 149: 245-254.  
  74. Divers TJ, Grice AL, Mohammed HO, Glaser AL, Wagner B. 2012. Changes in Borrelia burgdorferi ELISA antibody over time in both antibiotic treated and untreated horses. Acta Veterinaria Hungarica, 60: 421–429.
  75. Lavoie-Lamoureux A, Leclère M, Lemos K, Wagner B, Lavoie J-P. 2012. Markers of systemic inflammation in horses with heaves. J. Vet. Intern. Med., 26: 1419-1426.
  76. Wagner B, Goodman LB, Rollins A, Freer HS. 2013. Antibodies to OspC, OspF and C6 antigens as indicators for infection with Borrelia burgdorferi in horses. Equine Vet. J., 45: 533537.
  77. Keggan A, Freer H, Rollins A, Wagner B. 2013. Production of seven monoclonal equine immunoglobulins isotyped by multiplex analysis. Vet. Immunol. Immunopathol., 153: 187-193. 78 Kirchgessner MS, Freer H, Whipps CM, Wagner B. 2013. Detection of Borrelia burgdorferi Outer Surface Protein Antibodies in Wild White-Tailed Deer (Odocoileus virginianus) in New York and Pennsylvania, USA. Vet. Immunol. Immunopathol., 153: 165-169.
  78. Steelman SM, Johnson D, Wagner B, Stokes A, Chowdhary BP. 2013. Cellular and humoral immunity in chronic equine laminitis. Vet Immunol Immunopathol., 153: 217-226.
  79. Hamza E, Akdis C, Wagner B, Steinbach F, Marti E. 2013. In vitro induction of functional allergen-specific CD4+CD25high Treg cells in horses affected with insect bite hypersensitivity. Clin. Exp. Allergy, 43: 889-901.
  80. Detournay O, Morrison DA, Wagner B, Zarnegar B, Wattrang E. 2013. Genomic analysis and mRNA expression of equine type I interferon genes. J Interferon Cytokine Res., 33: 746-759.
  81. Kwon S, Moore JN, Robertson TP, Hurley DJ, Wagner B, Vandenplas ML. 2013. Disparate effects of LPS infusion and carbohydrate overload on inflammatory gene expression in equine laminae. Vet. Immunol. Immunopathol., 155: 1-8.
  82. Wagner B, Ainsworth DM, Freer H. 2013. Analysis of soluble CD14 and its use as a biomarker in neonatal foals with septicemia and horses with recurrent airway obstruction. Vet. Immunol. Immunopathol., 155: 124-128.
  83. Silva A, Wagner B, McKenzie HC, Desrochers AM, Furr MO. 2013. An investigation of the role of soluble CD14 in hospitalized, sick horses. Vet. Immunol. Immunopathol., 155: 264-269.
  84. Schnabel CL, Wagner S, Wagner B, Durán MC, Babasyan S, Nolte I, Pfarrer C, Feige K, Murua Escobar H, Cavalleri JMV. 2013. Evaluation of the reactivity of commercially available monoclonal antibodies with equine cytokines. Vet. Immunol. Immunopathol., 156: 1-19.
  85. Kydd J, Case R, Minke J, Audonnet JC, Wagner B, Antczak D. 2014. The immediate early protein of equine herpesvirus-1 (EHV-1) as a target for cytotoxic T lymphocytes in the Thoroughbred horse. J. Gen. Virol., 95: 1783-1789.
  86. Perkins GA, Goodman LB, Wimer C, Freer H, Babasyan S, Wagner B. 2014. Maternal Tlymphocytes in equine colostrum express a primarily inflammatory phenotype. Vet. Immunol. Immunopathol., 161: 141-150.
  87. Cizauskas CA, Turner WC, Wagner B, Küsters M, Vance RE, Getz WM. 2014. Gastrointestinal helminths may affect host susceptibility to anthrax through seasonal immune trade-offs. BMC Ecology, 14: 27.
  88. Perkins GA, Wagner B. 2015. The development of equine immunity: Current knowledge on immunology in the young horse. Equine Vet. J., 47: 267-274.
  89. Khatibzadeh SM, Gold CB, Keggan AE, Perkins GA, Glaser AL, Dubovi EJ, Wagner B. 2015. The West Nile virus specific immunoglobulin G (IgG) isotype response in vaccinated and infected horses is dominated by IgG1. AJVR, 76: 92-100.
  90. Nielsen MK, Rubinson EF, Chambers TM, Horohov DW, Wagner B, Betancourt A, Reedy S, Jacobsen S. 2015. Interaction between anthelmintic treatment and vaccine responses in ponies naturally infected with cyathostomins. Vet. Immunol. Immunopathol., 164: 110-117.
  91. Ortved KF, Wagner B, Calcedo R, Wilson JM, Schaefer DM, Nixon AJ. 2015. Humoral and cell-mediated immune response, and growth factor synthesis after direct intra-articular injection of rAAV2-IGF-I and rAAV5-IGF-I in the equine middle carpal joint. Human Gene Therapy, 26: 161-171.
  92. Schnabel CL, Steinig P, Schuberth HJ, Koy M, Wagner B, Wittig B, Juhls C, Willenbrock S, Murua Escobar H, Jaehnig P, Feige K, Cavaller JMV. 2015. Influences of Age and Sex on Leukocytes of Healthy Horses and their ex vivo Cytokine Release. Vet. Immunol. Immunopathol., 165: 64-74.
  93. Schnabel CL, Steinig P, Koy M, Schuberth HJ, Juhls C, Oswald D, Wittig B , Willenbrock S, Murua Escobar H, Pfarrer C, Wagner B, Jaehnig P, Moritz A, Feige K, Cavalleri JMV. 2015. Immune response of healthy horses to DNA constructs formulated with a cationic lipid transfection reagent. BMC Veterinary Research, 11:140.
  94. Stokol T, Daddona J, DeLeonardis C, Dong L, Wagner B. 2015. Generation and characterization of a monoclonal antibody against canine tissue factor. Vet. Immunol Immunopathol, 167: 178-184.
  95. Wagner B, Johnson J, Garcia-Tapia D, Honsberger N, King V, Earnhart C, Marconi R,  Meeus PFM. 2015. Comparison of Effectiveness of Cefovecin, Doxycycline, and Amoxicillin for the Treatment of Experimentally Induced Early Lyme Borreliosis. BMC Veterinary Research, 11:163.
  96. Wagner B, Goodman LB, Babasyan S, Freer H, Torsteinsdóttir S, Svansson V, Björnsdóttir S, Perkins GA. 2015. Antibody and cellular immune responses of naïve mares to repeated vaccination with an inactivated equine herpesvirus vaccine. Vaccine, 33:5588-5597.
  97. Cross JA, Cole BJ, Spatny KP, Sundman E, Romeo AA, Nicholson GP, Wagner B, Fortier LA. 2015. Leukocyte-Reduced Platelet-Rich Plasma Normalizes Matrix Metabolism in Torn Human Rotator Cuff Tendons. Am. J. Sports Med., 43: 2898-2906.
  98. Korn A, Miller D, Dong L, Buckles E, Wagner B, Ainsworth DM. 2015. Differential Gene Expression Profiles and Selected Cytokine Protein Analysis of Mediastinal Lymph Nodes of Horses with Chronic Recurrent Airway Obstruction (RAO) Support an Interleukin-17 Immune Response. PLOS One, 10: e0142622.
  99. Wagner B. 2016. IgE and allergy. Equine Vet. J., 48: 13-14.
  100. Pennington MR, Curtis TM, Divers TJ, Wagner B, Ness SL, Tennant BC, Van de Walle GR. 2016. Equine Mesenchymal Stromal Cells from Different Sources Efficiently Differentiate into Hepatocyte-Like Cells. Tissue Eng. Part C Methods, 22(6):596-607.
  101. Fogle J, Jacob M, Blikslager A, Edwards A, Wagner B, Dean K, Fogle C. 2017. Comparison of LPS and soluble CD14 measurement between clinically endotoxaemic and nonendotoxaemic horses. Equine Vet J, 49: 155-159.
  102. Slaughter KM, Halland SK, Schur LA, Wagner B, DeMel DM, Bertone JJ. Humoral response of Borrelia burgdorferi outer surface protein A (OspA) vaccination in equids. Equine Veterinary Education, in press.
  103. Wagner B, Perkins G, Babasyan S, Freer H, Keggan A, Goodman LB, Glaser A, Torsteinsdóttir S, Svansson V, Björnsdóttir S. 2017. Neonatal immunization with a single IL4/antigen dose induces increased antibody responses after challenge infection with equine herpesvirus type 1 (EHV-1) at weanling age. PLOS One, 12(1):e0169072.
  104. Bonelli F, Meucci V, Divers TJ, Wagner B, Intorre L, Sgorbini M. 2017. Kinetics of plasma procalcitonin, soluble CD14, CCL2 and IL-10 after a sublethal infusion of lipopolysaccharide in horses. Vet Immunol Immunopathol, 184:29-35. 
  105. Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJ, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgärtner W, Feige K, Pietschmann T, Cavalleri JM, Steinmann E. 2017. Immune protection against reinfection with nonprimate hepacivirus. Proc Natl Acad Sci U S A, 114: E2430-E2439.
  106. Schnabel CL, Babasyan S, Freer H, Wagner B. Quantification of equine immunoglobulin A in serum and secretions by a fluorescent bead-based assay. Vet Immunol Immunopathol, in press.

Awards and Honors

•    2002-2004 Research exchange grant from the Max Kade Foundation, Inc., New York, NY, USA
•    2006 Junior Faculty Travel Award, American Association of Immunologists (AAI)
•    2008 Junior Faculty Travel Award, American Association of Immunologists (AAI)
•    2009-2011 Harry M. Zweig Assistant Professorship in Equine Health
•    2010 AAVI Junior Scientist Travel Award for the 9th International Veterinary Immunology Symposium in Tokyo, Japan

Professional/Academic Affiliations

  • 2001-present Member of the DGfI (German Society of Immunology)
  • June 2003 Co-organizer, Havemeyer Foundation Workshop, “Genomic Applications to Equine Immunity,” Cornell University, June 19-22, 2003
  • 2004-present Member of the American Association of Immunologists (AAI)
  • 2005-2008 Member of the AAI Veterinary Immunology Committee
  • 2008-present Member of the American Association of Veterinary Immunologists (AAVI)
  • 2010-present Editorial Advisory Board, Veterinary Immunology and Immunopathology
  • 2013-2016 Equine Veterinary Journal's Editorial Consultants Board