The Cornell Feline Health Center Research Grants Program is a competitive grants program that provides up to $75,000 per year for up to two years to researchers at the Cornell University College of Veterinary Medicine for the study of health issues that directly affect feline welfare. Grants are reviewed by the College’s Scientific Review Committee and are awarded on the basis of scientific merit, feasibility of the proposed project, and potential for impact of the project on feline health, among other aspects.

FUNDED RESEARCH 

If you are a scientists or clinician in Cornell's College of Veterinary Medicine and you would like to know more about the grants program, please contact Dr. Bruce Kornreich, Director, Cornell Feline Health Center: FHC@cornell.edu

Scientific publications that have resulted from donor-sponsored research through this innovative program include:

DNA damage is a feature of feline injection-site sarcoma.
Kang S, Southard T, Hume KR.
Vet Comp Oncol. 2016 Jan 19.

Effect of gantacurium on evoked laryngospasm and duration of apnea in anesthetized healthy cats.
Martin-Flores M, Cheetham J, Campoy L, Sakai DM, Heerdt PM, Gleed RD.
Am J Vet Res. 2015 Mar;76(3):216-23.

Prevention of laryngospasm with rocuronium in cats: a dose-finding study.
Martin-Flores M, Sakai DM, Portela DA, Borlle L, Campoy L, Gleed RD.
Vet Anaesth Analg. 2016 Sep;43(5):511-8.

A novel corneal explant model system to evaluate antiviral drugs against feline herpesvirus type 1 (FHV-1).
Pennington MR, Fort MW, Ledbetter EC, Van de Walle GR.
J Gen Virol. 2016 Jun;97(6):1414-25.

A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats.
Aberdein D, Munday JS, Gandolfi B, Dittmer KE, Malik R, Garrick DJ, Lyons LA; 99 Lives Consortium.
Mamm Genome. 2017 Feb;28(1-2):47-55.

Structural and functional changes relevant to maxillary arterial flow observed during computed tomography and nonselective digital subtraction angiography in cats with the mouth closed and opened.
Scrivani PV, Martin-Flores M, van Hatten R, Bezuidenhout AJ.
Vet Radiol Ultrasound. 2014 May-Jun;55(3):263-71.

Maximal and submaximal mouth opening with mouth gags in cats: implications for maxillary artery blood flow.
Martin-Flores M, Scrivani PV, Loew E, Gleed CA, Ludders JW.
Vet J. 2014 Apr;200(1):60-4.

Mutation in spike protein cleavage site and pathogenesis of feline coronavirus.
Licitra BN, Millet JK, Regan AD, Hamilton BS, Rinaldi VD, Duhamel GE, Whittaker GR.
Emerg Infect Dis. 2013 Jul;19(7):1066-73.

Evaluation of maxillary arterial blood flow in anesthetized cats with the mouth closed and open.
Barton-Lamb AL, Martin-Flores M, Scrivani PV, Bezuidenhout AJ, Loew E, Erb HN, Ludders JW.
Vet J. 2013 Jun;196(3):325-31.

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.
Balmus G, Zhu M, Mukherjee S, Lyndaker AM, Hume KR, Lee J, Riccio ML, Reeves AP, Sutter NB, Noden DM, Peters RM, Weiss RS.
Hum Mol Genet. 2012 Aug 1;21(15):3408-20.

Mechanisms of coronavirus cell entry mediated by the viral spike protein.
Belouzard S, Millet JK, Licitra BN, Whittaker GR.
Viruses. 2012 Jun;4(6):1011-33.

Comparison of glomerular filtration rate determined by use of single-slice dynamic computed tomography and scintigraphy in cats.
Schmidt DM, Scrivani PV, Dykes NL, Goldstein RM, Erb HN, Reeves AP.
Am J Vet Res. 2012 Apr;73(4):463-9.

Resting energy expenditure per lean body mass determined by indirect calorimetry and bioelectrical impedance analysis in cats.
Center SA, Warner KL, Randolph JF, Wakshlag JJ, Sunvold GD.
J Vet Intern Med. 2011 Nov-Dec;25(6):1341-50.

Histopathologic features, immunophenotyping, clonality, and eubacterial fluorescence in situ hybridization in cats with lymphocytic cholangitis/cholangiohepatitis.
Warren A, Center S, McDonough S, Chiotti R, Goldstein R, Meseck E, Jacobsen M, Rowland P, Simpson K.
Vet Pathol. 2011 May;48(3):627-41.

Conformational changes in the capsid of a calicivirus upon interaction with its functional receptor.
Ossiboff RJ, Zhou Y, Lightfoot PJ, Prasad BV, Parker JS.
J Virol. 2010 Jun;84(11):5550-64.

HUS1 regulates in vivo responses to genotoxic chemotherapies.
Balmus G, Lim PX, Oswald A, Hume KR, Cassano A, Pierre J, Hill A, Huang W, August A, Stokol T, Southard T, Weiss RS.
J Virol. 2010 Jun;84(11):5550-64.

Descriptive epidemiology of feline upper respiratory tract disease in an animal shelter.
Dinnage JD, Scarlett JM, Richards JR.
J Feline Med Surg. 2009 Oct;11(10):816-25.

Evaluation of serum iohexol clearance for use in predicting carboplatin clearance in cats.
Bailey DB, Rassnick KM, Prey JD, Dykes NL.
Am J Vet Res. 2009 Sep;70(9):1135-40.

Single-dose pharmacokinetics and genotoxicity of metronidazole in cats.
Sekis I, Ramstead K, Rishniw M, Schwark WS, McDonough SP, Goldstein RE, Papich M, Simpson KW.
J Feline Med Surg. 2009 Feb;11(2):60-8.

The relationship of mucosal bacteria to duodenal histopathology, cytokine mRNA, and clinical disease activity in cats with inflammatory bowel disease.
Janeczko S, Atwater D, Bogel E, Greiter-Wilke A, Gerold A, Baumgart M, Bender H, McDonough PL, McDonough SP, Goldstein RE, Simpson KW.
Vet Microbiol. 2008 Apr 1;128(1-2):178-93.

Identification of regions and residues in feline junctional adhesion molecule required for feline calicivirus binding and infection.
Ossiboff RJ, Parker JS.
J Virol. 2007 Dec;81(24):13608-21.

Feline caliciviruses (FCVs) isolated from cats with virulent systemic disease possess in vitro phenotypes distinct from those of other FCV isolates.
Ossiboff RJ, Sheh A, Shotton J, Pesavento PA, Parker JS.
J Gen Virol. 2007 Feb;88(Pt 2):506-17.

Effect of donor age on success of spermatogenesis in feline testis xenografts.
Kim Y, Selvaraj V, Pukazhenthi B, Travis AJ.
Reprod Fertil Dev. 2007;19(7):869-76.

Phase I and pharmacokinetic evaluation of the combination of orally administered docetaxel and cyclosporin A in tumor-bearing cats.
McEntee MC, Rassnick KM, Bailey DB, Balkman CE, Flanagan JL, Beaulieu BB, Zgola MM, Lewis LD, Page RL.
J Vet Intern Med. 2006 Nov-Dec;20(6):1370-5.

Association of Helicobacter with cholangiohepatitis in cats.
Greiter-Wilke A, Scanziani E, Soldati S, McDonough SP, McDonough PL, Center SA, Rishniw M, Simpson KW.
J Vet Intern Med. 2006 Jul-Aug;20(4):822-7.

Recipient preparation and mixed germ cell isolation for spermatogonial stem cell transplantation in domestic cats.
Kim Y, Selvaraj V, Dobrinski I, Lee H, McEntee MC, Travis AJ.
J Androl. 2006 Mar-Apr;27(2):248-56.

Purified feline and canine transferrin receptors reveal complex interactions with the capsids of canine and feline parvoviruses that correspond to their host ranges.
Palermo LM, Hafenstein SL, Parrish CR.
J Virol. 2006 Sep;80(17):8482-92.

Association of Helicobacter with cholangiohepatitis in cats.
Greiter-Wilke A, Scanziani E, Soldati S, McDonough SP, McDonough PL, Center SA, Rishniw M, Simpson KW.
J Vet Intern Med. 2006 Jul-Aug;20(4):822-7.

Effects of administration of fluids and diuretics on glomerular filtration rate, renal blood flow, and urine output in healthy awake cats.
McClellan JM, Goldstein RE, Erb HN, Dykes NL, Cowgill LD.
Am J Vet Res. 2006 Apr;67(4):715-22.

Accuracy of increased thyroid activity during pertechnetate scintigraphy by subcutaneous injection for diagnosing hyperthyroidism in cats.
Page RB, Scrivani PV, Dykes NL, Erb HN, Hobbs JM.
Vet Radiol Ultrasound. 2006 Mar-Apr;47(2):206-11.

Association of the risk of development of hypothyroidism after iodine 131 treatment with the pretreatment pattern of sodium pertechnetate Tc 99m uptake in the thyroid gland in cats with hyperthyroidism: 165 cases (1990-2002).
Nykamp SG, Dykes NL, Zarfoss MK, Scarlett JM.
J Am Vet Med Assoc. 2005 May 15;226(10):1671-5.

Expression, bioactivity, and clinical assessment of recombinant feline erythropoietin.
Randolph JE, Scarlett JM, Stokol T, Saunders KM, MacLeod JN.
Am J Vet Res. 2004 Oct;65(10):1355-66. Erratum in: Am J Vet Res. 2004 Nov;65(11):1572.

Combinations of two capsid regions controlling canine host range determine canine transferrin receptor binding by canine and feline parvoviruses.
Hueffer K, Govindasamy L, Agbandje-McKenna M, Parrish CR.
J Virol. 2003 Sep;77(18):10099-105.

Residues in the apical domain of the feline and canine transferrin receptors control host-specific binding and cell infection of canine and feline parvoviruses.
Palermo LM, Hueffer K, Parrish CR.
J Virol. 2003 Aug;77(16):8915-23.

Subnormal concentrations of serum cobalamin (vitamin B12) in cats with gastrointestinal disease.
Simpson KW, Fyfe J, Cornetta A, Sachs A, Strauss-Ayali D, Lamb SV, Reimers TJ.
J Vet Intern Med. 2001 Jan-Feb;15(1):26-32.

Below is a list of some of the presentations and book chapters that have resulted from donor-sponsored research:

"Susceptibility of the Intact and Traumatized Feline Cornea to In Vitro Binding and Invasion by Acanthamoeba castellanii"
Eric C. Ledbetter1A, Longying Dong1B, Sung G. Kim2.
AClinical Sciences, BBiomedical Sciences, 1Cornell University, Ithaca, NY; 2Division of Microbiology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR.; 2011 Association for Vision and Ophthalmology Conference, Ft. Lauderdale, Florida, May 5, 2011. Abstract.

"Activation of viral envelope proteins by host cell proteases: tales from influenza and coronaviruses"
Gary R. Whittaker
2010 (July), Gordon Research Conference on proprotein processing, trafficking, and secretion, New London, NH.

"Mutations in type I feline coronavirus spike protein associated with feline infectious peritonitis"
Jean Millet (Whittaker lab)
2011 (June), XIIth International Nidovirus Symposium, Traverse City, MI.

"Pathogenicity of feline coronavirus is associated with mutations at a conserved furin cleavage site of the spike viral envelope glycoprotein"
Jean Millet (Whittaker lab)
2012 (July), American Society for Virology Meeting, Madison WI.

A Comparison of Cyproheptadine and Clomipramine for the Treatment of Spraying Cats.
In: Overall KL, Mills DS, Heath SE, Horwitz D, editors.
Kroll T, Houpt KA (2001)
Proceedings of the 3rd International Congress of Veterinary Behavioural Medicine.
Potters Bar: Universities Federation for Animal Welfare. pp. 184–185.

"Detection of biofilm formation and nanobacteria under long-term cell culture conditions in serum samples of cattle, goats, cats, and dogs"
Barr SC, Linke RA, Janssen D, Guard CL, Smith MC Daugherty CS, et al.
(2003), Am J Vet Res 64: 176–182.

"Detection and pathogenic role of amoebae in feline corneal disease"
Ledbetter EC, Kim SG, Rohela M, Schaefer DMW
Vet Ophthalmol 2010; 13 (6): Abstract 021.