Carole Harbison

Faculty Mentor: Dr. Colin Parrish
Current Position: Senior Scientist II, Takeda

Brief Biography
Carole grew up in Rochester, NY and received her undergraduate degree in Biology from Oberlin College in 2000. Her thesis work during her BA program studied the ecology of jack-in-the-pulpit, and she held various research positions studying topics ranging from foot and mouth disease to rattlesnake behavior. After graduation, she worked at Genencor International, a biotechnology company in the San Francisco area, for four years before deciding to pursue veterinary research training. Her career interests include pathology and emerging infectious diseases.

Education
PhD, Comparative Biomedical Sciences, Cornell University, 2011
DVM, Veterinary Medicine, Cornell University, 2010
BS, Biology, Oberlin College

Publications & Presentations
1: Zhuang K, Leda AR, Tsai L, Knight H, Harbison C, Gettie A, Blanchard J, Westmoreland S, Cheng-Mayer C. Emergence of CD4 independence envelopes and astrocyte infection in R5 simian-human immunodeficiency virus model of encephalitis. J Virol. 2014 Aug;88(15):8407-20. doi: 10.1128/JVI.01237-14. Epub 2014 May 14. PubMed PMID: 24829360; PubMed Central PMCID: PMC4135954.  

2: Chu VC, McElroy LJ, Aronson JM, Oura TJ, Harbison CE, Bauman BE, Whittaker GR. Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus. Virol J. 2007 Feb 26;4:20. PubMed PMID: 17324273; PubMed Central PMCID: PMC1810517.  

3: Harbison CE, Chiorini JA, Parrish CR. The parvovirus capsid odyssey: from the  cell surface to the nucleus. Trends Microbiol. 2008 May;16(5):208-14. doi: 10.1016/j.tim.2008.01.012. Epub 2008 Apr 9. Review. PubMed PMID: 18406140.  

4: Harbison CE, Lyi SM, Weichert WS, Parrish CR. Early steps in cell infection by parvoviruses: host-specific differences in cell receptor binding but similar endosomal trafficking. J Virol. 2009 Oct;83(20):10504-14. doi: 10.1128/JVI.00295-09. Epub 2009 Aug 5. PubMed PMID: 19656887; PubMed Central PMCID: PMC2753109.  

5: Harbison CE, Weichert WS, Gurda BL, Chiorini JA, Agbandje-McKenna M, Parrish CR. Examining the cross-reactivity and neutralization mechanisms of a panel of mAbs against adeno-associated virus serotypes 1 and 5. J Gen Virol. 2012 Feb;93(Pt 2):347-55. doi: 10.1099/vir.0.035113-0. Epub 2011 Nov 9. PubMed PMID: 22071509; PubMed Central PMCID: PMC3352341.  

6: Allison AB, Harbison CE, Pagan I, Stucker KM, Kaelber JT, Brown JD, Ruder MG,  Keel MK, Dubovi EJ, Holmes EC, Parrish CR. Role of multiple hosts in the cross-species transmission and emergence of a pandemic parvovirus. J Virol. 2012  Jan;86(2):865-72. doi: 10.1128/JVI.06187-11. Epub 2011 Nov 9. PubMed PMID: 22072763; PubMed Central PMCID: PMC3255849.  

7: Cureton DK, Harbison CE, Cocucci E, Parrish CR, Kirchhausen T. Limited transferrin receptor clustering allows rapid diffusion of canine parvovirus into  clathrin endocytic structures. J Virol. 2012 May;86(9):5330-40. doi: 10.1128/JVI.07194-11. Epub 2012 Feb 22. PubMed PMID: 22357278; PubMed Central PMCID: PMC3347332.  

8: Kaelber JT, Demogines A, Harbison CE, Allison AB, Goodman LB, Ortega AN, Sawyer SL, Parrish CR. Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs. PLoS Pathog. 2012;8(5):e1002666. doi: 10.1371/journal.ppat.1002666. Epub 2012 May 3. PubMed PMID: 22570610; PubMed Central PMCID: PMC3342950.  

9: Markovich JE, Stucker KM, Carr AH, Harbison CE, Scarlett JM, Parrish CR. Effects of canine parvovirus strain variations on diagnostic test results and clinical management of enteritis in dogs. J Am Vet Med Assoc. 2012 Jul 1;241(1):66-72. doi: 10.2460/javma.241.1.66. PubMed PMID: 22720989.  

10: Harbison CE, Ellis ME, Westmoreland SV. Spontaneous cervicovaginal lesions and immune cell infiltrates in nonhuman primates. Toxicol Pathol. 2013;41(7):1016-27. doi: 10.1177/0192623313477754. Epub 2013 Feb 20. PubMed PMID: 23427274; PubMed Central PMCID: PMC3716859.  

11: Harbison C, Zhuang K, Gettie A, Blanchard J, Knight H, Didier P, Cheng-Mayer  C, Westmoreland S. Giant cell encephalitis and microglial infection with mucosally transmitted simian-human immunodeficiency virus SHIVSF162P3N in rhesus  macaques. J Neurovirol. 2014 Feb;20(1):62-72. doi: 10.1007/s13365-013-0229-z. Epub 2014 Jan 25. PubMed PMID: 24464410.  

12: Ren W, Mumbauer A, Zhuang K, Harbison C, Knight H, Westmoreland S, Gettie A,  Blanchard J, Cheng-Mayer C. Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIVSF162P3N molecular clones in rhesus macaques. Retrovirology. 2013 Jan 31;10:9. doi: 10.1186/1742-4690-10-9. PubMed PMID: 23369442; PubMed Central PMCID: PMC3571932.