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Advancing the health and well-being of animals and people


Stem Cell Biology Researchers

Research at the College of Veterinary Medicine meets the clinical and research demands of human and animal health. Consistently ranked among the top veterinary colleges in the country, the College leads in scientific discovery. Faculty expertise focus on the interface between scientific research and clinical practice as well as a commitment to animal and human health.

Faculty Index Faculty A-C Faculty D-L Faculty M-R Faculty S-Z

Faculty
Area of Interest
Role of the DNA mismatch repair (MMR) family in mammalian meiosis and recombination; RNA binding Argonauts in germline and other mammalian tissue stem cells; Genetics and development; Gamete biology, fertilization & reproductive tract
Identification and characterization of genes that are mutated in breast tumors; Reproductive biology; investigation of the role that novel, highly-abundant, and egg-restricted molecules play in reprogramming process; Epigenetic regulation of preimplantation development and embryonic fate decisions
Equine immune system with specific interest in immunodeficiencies and developmental immunity of the foal; immunomodulatory therapies and response to vaccines; comparative animal model for human disease research; Mechanisms of regulation of B cell differentiation using equine bone marrow- and fetal liver-derived hematopoietic stem cells
Cellular and molecular mechanisms involved in the development of arthritis with the ultimate goal of identifying novel molecular targets for the treatment or prevention of arthritis; refining the clinical application of stem cells for treatment of orthopaedic diseases; cartilage and ligament regeneration; induced pluripotent stem cell and bone marrow stem cell research; biomedical mechanics
Molecular processes underlying cardiac stem cell and smooth muscle cell development and function
Transcriptional and cellular control of tissue morphogenesis; molecular and cellular events that direct the formation of tissues and organs during vertebrate embryogenesis; cell signaling; cellular behaviors and cell shape during development

Biomedical imaging; cellular excitation and relaxation; sarcoplasmic reticular calcium release channels; molecular processes underlying excitation-contraction coupling; sarcolemnal ion channels; molecular processes underlying cardiac stem cell and smooth muscle cell development and function
Diseases of multiple species, defining epidemiology and risk factors for diseases
Genetic modeling of human cancer in the mouse; early detection and monitoring of carcinogenesis; neoplasms of reproductive and endocrine systems; Role of stem cell compartment in carcinogenesis, mouse models, stem cell pathology
Biomedical mechanics; joint pathobiology and cartilage repair with growth factor gene-enhanced chondrocyte and stem cell transplantation techniques; genetic characterization of OCD in animals and man using microarray expression studies; clinical application of growth factor recombinant proteins and gene therapy for improved joint, tendon, and bone repair
Mouse genetics and functional genomics; genomic instability; genetic recombination; genetics of gametogenesis and development; use of ES cells to mutagenize the mouse genome
Micro and nano-biotechnology; biomaterials & drug delivery; Reproductive Physiology; Cell biology of male germ cells; preservation of genetic diversity; comparative biology of male germ cells; signaling and metabolism of sperm during capacitation; organization of lipid raft membrane sub-domains in sperm; applications of technologies using reproductive stem cells for wildlife conservation
How herpesviruses cause disease in dogs and cats, the causes of breast cancer in animals, and how stem cells might be used to treat injuries in horses. All of these studies in companion animals can also help to improve human health, and in each of these projects, Dr. Van de Walle relies on model systems that represent the fundamental facts about a disease or condition, but that lack unnecessary complexities.
Genome maintenance mechanisms, cellular responses to genotoxins; mouse cancer models, DNA damage signaling, genomic instability; lung stem cells
Cell cycle regulation; cell differentiation; myeloblastic hematological tumor cell line, HL-60; Cancer chemoprevention; biomaterials & drug delivery; oncogenes; genetics