Advancing the health and well-being of animals and people

Principal Investigator: Jonathan Cheetham

Department of Clinical Sciences
Email:; Phone: 607-253-3100
Sponsor: University of Pittsburgh - NIH
Grant Number: 0022723 (121444-1)
Title: A Regenerative Medicine Approach for TMJ Meniscus Restoration: Temporomandibular Joint Meniscus Replacement Pig Model GLP
Project Amount: $177,475
Project Period: 07/01/13-06/30/14

DESCRIPTION (Provided by Applicant): The long-term objective of this work is the development of a safe and effective regenerative medicine therapy for replacement of the temporomandibular joint (TMJ) meniscus (disc) with associated protection of the TMJ articulating surfaces. The proposed studies are conceptually based upon the use of an extracellular matrix (ECM) scaffold as an inductive template for in-vivo TMJ disc reconstruction. A porcine model of bilateral TMJ disc removal will be used to investigate the remodeling process.