Advancing the health and well-being of animals and people

Principal Investigator: Robin Gleed

Contact Information: Email:; Phone: 607-253-33237
Sponsor: Transonic Systems, Inc.- NIH
Grant Number: 64757
Title: Large Animal Model of Hydrocephalus
Annual Direct Cost: $18,956
Project Period: 04/13/11-05/31/11

DESCRIPTION (provided by applicant): The treatment of children with hydrocephalus requires chronically implanting a shunt tube between the ventricles of the brain and the abdomen through which excess cerebrospinal fluid (CSF) can escape from the cranium. Data collected previously have confirmed that we can measure CSF flow in shunt tubing non-invasively. This gives hope for a method of easily detecting hydrocephalic shunt failure in the emergency room. The next phase of the research requires testing the method and all its components in an animal model of hydrocephalus. In these experiments we will implant healthy sheep with a shunt tube device that can measure CSF flow pressure, and temperature. After collecting baseline data we will include hydrocephalus by kaolin injection into the subdural space and the subsequent changes in pressure and flow monitored.