Advancing the health and well-being of animals and people

Principal Investigator:  Yung-Fu Chang

Contact Information: Email:; Phone: 607-253-3675
Sponsor: NIH-Virginia Polytechnic Institute & State University
Grant Number: 431602-19024
Title: Comparative Transcriptome Analysis of C. Difficile Strains
Annual Direct Cost: $190,005
Project Period: 07/16/10-07/15/12

DESCRIPTION (provided by applicant): The experiments proposed in this project will compare five C. difficile strains, provide transcriptome and proteome sequence data for these strains, verify and complement the genome sequence annotations of available sequenced strains, provide insights into the role of core, divergent and strain specific genes in C. difficile pathogenesis, and expand the Pathogen Resource Integration Center (PATRIC) system by inclusion of tools for the RNA-seq analysis pipeline that can be used for other bacterial RNA-seq projects.