Population Medicine & Diagnostic Sciences


Cats  

Advancing the health and well-being of animals and people


Dogs  

Advancing the health and well-being of animals and people


Pig  

Advancing the health and well-being of animals and people


Cells  

Advancing the health and well-being of animals and people


Cattle  

Advancing the health and well-being of animals and people


Horses  

Advancing the health and well-being of animals and people


Laura Goodman

Laura GoodmanSenior research associate in Molecular Diagnostics and Virology
Animal Health and Diagnostic Center, Cornell University


Department of Population Medicine and Diagnostic Sciences
College of Veterinary Medicine
Cornell University
Ithaca, New York 14853
607-253-3631
laura.goodman@cornell.edu

Research Interests

My primary research focus is on development of diagnostic assays and techniques to detect emerging pathogens. I have studied mechanisms of pathogen emergence in veterinary models and have used a molecular epidemiology approach to identify virulence markers in pathogens and hosts. Correlates of immunity and immune evasion are also central themes from both a basic and applied perspective. I am interested in the diagnosis and prevention of animal disease and its relevance to One Health.


Education

  • 2007  Ph.D., Cornell University, Comparative Biomedical Sciences: Infectious disease-virology, with minors in epidemiology and microbiology
  • 2002   B.S., University of Michigan- Ann Arbor (Honors Program), Microbiology and Global Change

Research and Professional Experience

  • 2013-pres. Research Associate / Senior Research Associate
    Cornell Animal Health Diagnostic Center and Population Medicine & Diagnostic Sciences
    Focus: Molecular assay design and adaptation to next-generation technologies
  • 2011-2013 Postdoctoral Associate
    Cornell Animal Health Diagnostic Center and Population Medicine & Diagnostic Sciences
    Focus: Correlates of immune protection
    Advisor: Dr. Bettina Wagner, DVM, Dr. med. vet. habil.
  • 2010-2011 Research Fellow
    Harvard Medical School Dept. of Pathology and Dana-Farber Cancer Institute
    Focus: Viral antigen recognition
    Advisor: Dr. Harvey Cantor, MD
  • 2007-2010 Postdoctoral Fellow
    Cornell University Baker Institute for Animal Health
    Focus: Viral receptor binding and host switching
    Advisor: Dr. Colin Parrish, PhD

Honors and Awards

  • 2009 Individual NIH Ruth L. Kirschstein National Research Service Award (F32)
  • 2003-06 Institutional NIH Ruth L. Kirschstein National Research Service Award (T32) appointment
  • 2002 University Honors from the University of Michigan, Ann Arbor
  • 1999 Class Honors from the University of Michigan, Ann Arbor

Professional Memberships

  • American Society for Virology (ASV)
  • American Society for Microbiology (ASM)
  • American Association of Veterinary Laboratory Diagnosticians (AAVLD)



Selected Publications

  1. Franz M, Goodman LB, Van De Walle G, Osterrieder N, Greenwood A. A point mutation in a herpesvirus co-determines neuropathogenicity and viral shedding. Viruses. In Press.
  2. Wagner B, Perkins G, Babasyan S, Freer H, Keggan A, Goodman LB, Glaser A, Torsteinsdóttir S, Svansson V, and Björnsdóttir S. Neonatal immunization with a single IL-4/antigen dose induces increased antibody responses after challenge infection with equine herpesvirus type 1 (EHV-1) at weanling age. PLoS One. In Press.
  3. Goodman LB, Anderson RR, Slater M, Ortenberg E, Renshaw RW, Chilson BD, Laverack MA, Beeby JS, Dubovi EJ, Glaser AL. High-throughput detection of respiratory pathogens in animal specimens by nanoscale PCR. Journal of Visualized Experiments. 2016 Nov 28;(117).
  4. Wagner B, Goodman LB, Babasyan S, Freer H, Torsteinsdóttir S, Svansson V, Björnsdóttir S, Perkins GA. Antibody and cellular immune responses of naïve mares to repeated vaccination with an inactivated equine herpesvirus vaccine. Vaccine. 2015 Oct 13;33(42):5588-97.
  5. Perkins GA, Goodman LB, Wimer C, Freer H, Babasyan S, Wagner B. Maternal T-lymphocytes in equine colostrum express a primarily inflammatory phenotype. Vet Immunol Immunopathol. 2014 Oct 15;161(3-4):141-50.
  6. Wagner B, Goodman LB, Rollins A, Freer H. Antibodies to OspC, OspF and C6 antigens as indicators for infection with Borrelia burgdorferi in horses. Equine Veterinary Journal. 2013 Sep;45(5):533-7
  7. Kaelber JT, Demogines A, Harbison CE, Allison AB, Goodman LB, Ortega AN, Sawyer SL, Parrish CR. Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs. PLoS Pathogens 8(5): Epub 2012 May 3.
  8. Goodman LB, Wimer C, Gold C, Dubovi EJ, Wagner B. Immunological correlates of vaccination and infection for equine herpesvirus type 1. Clinical and Vaccine Immunology 2012 Feb;19(2):235-41.
  9. Goodman LB, Lyi SM, Johnson NC, Cifuente JO, Hafenstein S, Parrish CR. The binding site on the transferrin receptor for the parvovirus capsid, and the effects of altered affinity on cell uptake and infection. Journal of Virology 2010; 84(10):4969-78
  10. Perkins GA, Goodman LB, Tsujimura K, Van de Walle GR, Kim SG, Dubovi E, Osterrieder N. Investigation of the prevalence of neurologic equine herpes virus type 1 (EHV-1) in a 23-year retrospective analysis (1984-2007). Veterinary Microbiology 2009;139(3-4):375-8
  11. Perkins GA*, Goodman LB*, Dubovi EJ, Kim SG, Osterrieder N. Detection of equine herpesvirus-1 in nasal swabs of horses by quantitative real-time PCR. Journal of Veterinary Internal Medicine 2008; 22(5):1234-8. *Indicates shared first authors
  12. Goodman LB, Loregian A, Perkins GA, Nugent J, Buckles EL, Mercorelli B, Kydd JH, Palù G, Smith KC, Osterrieder N, Davis-Poynter N. A Point Mutation in a Herpesvirus Polymerase Determines Neuropathogenicity. PLoS Pathogens 2007; 3(11):e160
  13. Rosas CT, Tischer BK, Perkins GA, Wagner B, Goodman LB, Osterrieder N. Live-attenuated recombinant equine herpesvirus type 1 (EHV-1) induces a neutralizing antibody response against West Nile virus (WNV)H. Virus Research 2007; 125(1):69-78
  14. Goodman LB, Wagner B, Flaminio MJ, Sussman KH, Metzger SM, Holland R, Osterrieder N. Comparison of the efficacy of inactivated combination and modified-live virus vaccines against challenge infection with neuropathogenic equine herpesvirus type 1 (EHV-1). Vaccine 2006; 24(17):3636-45
  15. Rosas CT, Goodman LB, von Einem J, Osterrieder N. Equine herpesvirus type 1 modified live virus vaccines: quo vaditis? Expert Review of Vaccines 2006; 5:119-31
  16. Kasoumov T, Brunengraber LL, Comte B, Puchowicz M, Jobbins K, Thomas K, David F, Kinman R, Wehrli S, Dahms W, Kerr D, Nissim I, Brunengraber H. New secondary metabolites of phenylbutyrate in humans and rats. Drug Metabolism and Disposition 2004; 32(1):10-9
  17. Johnsrud EK, Koukouritaki SB, Divakaran K, Brunengraber LL, Hines RN, McCarver DG. Human hepatic CYP2E1 expression during development. Journal of Pharmacology and Experimental Therapeutics 2003; 307(1):402-7