Population Medicine & Diagnostic Sciences


Cats  

Advancing the health and well-being of animals and people


Dogs  

Advancing the health and well-being of animals and people


Pig  

Advancing the health and well-being of animals and people


Cells  

Advancing the health and well-being of animals and people


Cattle  

Advancing the health and well-being of animals and people


Horses  

Advancing the health and well-being of animals and people


Marjory Brooks

Brooks

 

Section Director-Comparative Coagulation Laboratory
Animal Health Diagnostic Center
College of Veterinary Medicine
Cornell University
Ithaca, New York 14853
Phone: 607-253-3648
e-mail: mbb9@cornell.edu
Comparative Coagulation Laboratory

 

 

Research Interests

Comparative hemostasis: canine models of hereditary bleeding disorders, biomarkers of hypercoagulability in animals, role of transmembrane lipid movement in platelet apoptotic vs. activation response.

Education

  • B.S. - 1977 Cornell University - Animal Science
    DVM - 1981 Cornell University - Veterinary Medicine


Certifications and Licenses

  • Board Certification in Veterinary Internal Medicine 1988
  • NY licensed and accredited


Awards, Honors and Membership in Honorary Societies

  • 1986 Outstanding Resident Research Project Award, Animal Medical Center, NY, NY
  • 1988 Diplomate, American College of Veterinary Medicine
  • 2006 Dr. Jack Mara Am. College of Vet. Emergency and Critical Care Scientific Award


Research and Professional Experience

  • 1981-1983 Henry Bergh Hospital - ASPCA, New York, NY Staff clinician
  • 1983-1984 The Animal Medical Center, New York, NY Medical and Surgical Intern
  • 1984-1986 The Animal Medical Center, New York, NY Donaldson-Atwood Cancer Clinic Medical-oncology resident
  • 1986-1988 The Animal Medical Center, New York, NY Donaldson-Atwood Cancer Clinic Associate staff oncologist
  • 1988-1994 Comparative Hematology Laboratory Wadsworth Center for Laboratories & Research New York State Department of Health, Albany NY Research Scientist
  • 1994 Chairman, WCL&R Animal Welfare Committee
  • 1994-present Comparative Coagulation Section Diagnostic Center - College of Veterinary Medicine Cornell University, Ithaca NY Senior Research Associate, Asst. Dir


Professional Society Memberships

  • American College of Veterinary Internal Medicine
  • American Veterinary Medical Association
  • American Association of Blood Banks
  • Association of Veterinary Hematology and Transfusion Medicine
  • New York State Veterinary Medical Association
  • Veterinary Cancer Society
  • Ad Hoc Reviewer for the following journals:
      • American Journal of Veterinary Research
      • Animal Genetics
      • Journal of the American Veterinary Medical Association
      • Journal of Veterinary Internal Medicine
      • Canadian Veterinary Journal


Selected Publications

  1. Brooks MB, Matus RE, Leifer CE, Alfieri A, and Patnaik A. Chemotherapy versus chemotherapy and radiation therapy for the treatment of canine tonsillar carcinoma. J Vet Int Med 1988; 2:206-211.
  2. Brooks MB, Dodds WJ. Factor IX deficiency (hemophilia B) in two male domestic shorthaired cats. J Am Anim Hosp Assoc 1989: 25:153-155.
  3. Raymond SL, Jones DW, Brooks MB, Dodds WJ. Clinical and laboratory features of a severe form of von Willebrand disease in Shetland sheepdogs. J Am Vet Med Assoc 1990;197:1342-1346.
  4. Brooks MB, Leith GS, Allen AK, Woods PR, Benson RB, and Dodds WJ. Bleeding disorder (von Willebrands disease) in a quarterhorse. J Am Vet Med Assoc 1991; 198:114-116.
  5. Benson RE, Catalfamo JL, Brooks MB, and Dodds WJ. A sensitive immunoassay for von Willebrand factor. J of Immunoassay 1991;12:371-390.
  6. Brooks MB, Dodds WJ, and Raymond SL. Epidemiologic features of von Willebrands disease in Doberman pinschers, Scottish terriers, and Shetland sheepdogs: 260 cases (1984-1988). J Am Vet Med Assoc 1992;200:1123-1127.
  7. Brooks M and Catalfamo J. Buccal mucosa bleeding time is prolonged in canine models of primary hemostatic disorders. Thrombosis and Haemostasis 1993;70:777-780.
  8. Cook AK, Werner LL, O'Neill SL, Brooks MB, Feldman BF. Factor X deficiency in a Jack Russell Terrier. Vet Clin Path 1993;22:68-71.
  9. Stone MS, Johnstone IB, Brooks MB, Bollinger TK, Cotter, SM. Lupus-type anticoagulant in a dog with hemolysis and thrombosis. J Vet Intern Med 1994;8:57-61.
  10. Knowler C, Giger U, Brooks MB. Factor XI deficiency in Kerry blue terriers. J Am Vet Med Assoc 1994;205:1557-1561.
  11. Feldman DG, Brooks MB, Dodds WJ. Hemophilia B (Factor IX deficiency) in a family of German shepherd dogs. J Am Vet Med Assoc 1995;206:1901-1905.
  12. Joseph SA, Brooks MB, Coccari PJ, and Riback SC. Hemophilia A in a German shorthaired pointer: clinical presentation and diagnosis. J Am Anim Hosp Assoc 1996;32:25-28.
  13. Sugahara Y, Catalfamo J, Brooks M, Hitomi E, Bajaj S, and Kurachi K. Isolation and characterization of canine factor IX: plasma concentration and implications for gene therapy studies. Thrombosis and Haemostasis 1996;75:450-455.
  14. Brooks M, Raymond S, and Catalfamo J. Severe recessive von Willebrand's disease in German wirehaired pointers. J Am Vet Med Assoc 1996;209:926-929.
  15. Brooks M, Raymond S, and Catalfamo J. Plasma von Willebrand factor antigen concentration as predictor of von Willebrand's status in German wirehaired pointers. J Am Vet Med Assoc 1996;209:930-933.
  16. Gookin Jl, Brooks MB, Catalfamo JL, Bunch SE, Munana KR. Factor X deficiency in a cat. J Am Vet Med Assoc 1997;211:576-579.
  17. Brooks MB, Gu W, Ray K. Complete deletion of factor IX gene and inhibition of factor IX activity in a Labrador Retriever with hemophilia B. J Am Vet Med Assoc 1997;211:1418-1421.
  18. Lisciandro SC, Hohenhaus A, Brooks MB, Coagulation abnormalities in 22 cats with naturally occurring liver disease. J Vet Intern Med 1998;12:71-75.
  19. Ray J, Brooks MB, Suh Y, Ray K. A PCR-RFLP marker in canine von Willebrand factor gene (vWF). An Genet 1998;29:406-407.
  20. Brooks M. A review of canine inherited bleeding disorders: biochemical and molecular strategies for disease characterization and carrier detection. J of Heredity 1999; 20:112-118.
  21. Brooks M. Hereditary Bleeding Disorders in Dogs and Cats. Vet Med June 1999; 94:555-564.
  22. Stokol T, Brooks M, Erb H, Mauldin, GE. Evaluation of kits for the detection of fibrin(ogen) degradation products in dogs. J Vet Intern Med 1999;13:478-484.
  23. Gu W, Brooks M, Catalfamo J, Ray J, Ray K. Large deletion and insertion mutations cause severe hemophilia B in dogs. Thrombosis and Haemostasis 1999;82:1270-1275.
  24. Randolph JF, DeMarco JA, Center SA, Kantrowitz L, Crawford MA, Scarlett JM, Brooks M. Prothrombin, activated partial thromboplastin, proteins induced by vitamin K absence or antagonists clotting times in 20 hyperthyroid cats before and after methimazole treatment. J Vet Intern Med 2000;14:56-59.
  25. Stokol T, Brooks MB, Erb HN, Mauldin GE. D-dimer concentrations in healthy dogs and dogs with disseminated intravascular coagulation Am J Vet Res 2000;61:393-398.
  26. Lisciandro GR, Brooks M, Catalfamo JL. Contact factor deficiency in a German Shorthaired Pointer without clinical evidence of coagulopathy. J Vet Intern Med 2000;14:308-310.
  27. Brooks M and Jacobson J. Unexpected turn on a rat poisoning. Veterinary Forum 2000; August: 76-78.
  28. Otto CM, Rieser TM, Brooks MB, Russell MW. Hypercoagulability in dogs with parvoviral enteritis. J Am Vet Med Assoc 2000:217;1500-1504.
  29. Stokol T, Brooks MB, Erb HN. Effect of citrate concentration on coagulation test results in dogs. J Am Vet Med Assoc 2000:217;1672-1677.
  30. Rathgeber RA, Brooks M, Bain FT, Byars TD. Von Willebrand disease in a thoroughbred broodmare and foal. J Vet Intern Med 2001;15:63-66.
  31. Brooks MB, Erb HN, Foureman P, Ray K. Von Willebrand disease phenotype and von Willebrand factor marker genotype in Doberman Pinscher dogs. Am J Vet Res 2001;62:364-369.
  32. Scott-Moncrieff JC, Treadwell NG, McCullough SM, Brooks MB. Hemostatic abnormalities in dogs with primary immune-mediated hemolytic anemia. J Am Anim Hosp Assoc 2001;37:220-227.
  33. Wardrop KJ, Brooks MB. Stability of hemostatic proteins in canine fresh frozen plasma units. Vet Clin Pathol 2001;30:91-95.
  34. Brooks MB, Castillo H, Oltenacu PA. Heritability of von Willebrand factor in German Wirehaired Pointers Vet Q 2001;23:126-128.
  35. Brooks MB, Catalfamo JL, Brown HA, Ivanova P, Lovaglio J. A hereditary bleeding disorder of dogs caused by a lack of platelet procoagulant activity. Blood 2002;99:2434-2441.
  36. Patterson MM, Jackson LR, Brooks MB, Catalfamo JL. Type 3 von Willebrand’s disease in a Rhesus monkey Comparative Medicine 2002;52:368-371.
  37. Troxel MT, Brooks MB, Esterline, ML. Congenital factor XI deficiency in a domestic shorthair cat. J Am Anim Hosp Assoc 2002;38:549-553.
  38. de Laforcade AM, Shaw SP, Freeman LM, Brooks MB, Rozanski EA, Rush JE. Coagulation parameters in dogs with naturally occurring sepsis. J Vet Intern Med 2003;17:674-679.
  39. Brooks MB, Gu W, Barnas JL, Ray J, Ray K. A Line 1 insertion in the factor IX gene segregates with mild hemophilia B in dogs. Mammalian Genome 2003;14:788-795.
  40. Thompson MF, Scott-Moncrieff JC, Brooks MB. Effect of a single plasma transfusion on thromboembolism in 13 dogs with primary immune-mediated hemolytic anemia. J Am Anim Hosp Assoc 2004;40:446-454.
  41. Brooks MB. Evaluation of a chromogenic assay to measure Factor Xa inhibitory activity of unfractionated heparin in canine plasma. Vet Clin Pathol 2004;33:208-214.
  42. Brooks MB, Barnas JL, Fremont JJ, Ray J. Co-segregation of a Factor VIII microsatellite marker with mild hemophilia A in Golden retrievers. J Vet Intern Med 2005;19:205-210.
  43. Heseltine JC, Panciera DL, Troy GC, Monroe WE, Brooks MB. Effect of levothyroxine administration on hemostatic analytes in Doberman pinschers with von Willebrand disease. J Vet Intern Med 2005;19:523-527.
  44. Stokol TS, Erb HN, DeWilde L, Tornquist S, Brooks MB. Evaluation of latex agglutination kits for detection of fibrin(ogen) degradation products and D-dimer in horses. Vet Clin Pathol 2005; 34: 375-382.
  45. Brooks MB and DeWilde LA. Feline Factor XII deficiency. Compendium on Continuing Education for the Practicing Veterinarian. 2006; 28:148-156.
  46. Couto CG, Lara A, Iazbik MC, Brooks MB. Evaluation of Platelet Aggregation Using a Point-of Care Instrument in Retired Racing Greyhounds. J Vet Int Med 2006;20:365-370.
  47. Brooks MB. Transfusion Reactions. NAVC Clinician’s Brief. 2006;4:61-64.
  48. Trammel RA, Brooks MB, Cox L, Ding M, Wagenknecht DR, Rehg JR, McIntyre JM, Toth LA. Fatal hemorrhagic diathesis associated with mild Factor IX deficiency in PL/J Mice. Comp Med 2006;56:426-434.
  49. Brooks M. Evaluating the bleeding patient. NAVC Clinician’s Brief. 2006;11:83-86.
  50. Toulza O, Center SA, Brooks MB, Erb HN, Warner K, Deal W. Protein C deficiency in dogs with liver disease. J Am Vet Med Assoc 2006;229:1761-1771.
  51. Alwood AJ, Downend AB, Brooks MB, Slenksy KA, Fox JA, Simpson SA, Waddell LS, Baumgardner JE, Otto CM. Anticoagulant effects of low molecular weight heparins in healthy cats. J Vet Intern Med 2007;21:378-387.
  52. Brooks MB, Catalfamo JL, Friese P, Dale GL. Scott syndrome dogs have impaired coated platelet formation and calcein-release but normal mitochondrial depolarization. J Thromb Haemost 2007;5:1972-1974.
  53. Kaae JA, Callan MB, Brooks MB. Hereditary factor VII deficiency in the Alaskan Klee Kai. J Vet Intern Med 2007;21:976-981.
  54. Brooks MB, MacNguyen R, Hall R, Gupta R, Booth JG. Indirect carrier detection of canine hemophilia A using factor VIII microsatellite markers. An Genetics 2008;39:278-283.
  55. Stokol TS, Brooks M, Rush JE, Rishniw M, Erb H, Rozanski E, Kraus M, Gelzer A. Hypercoagulability in cats with cardiomyopathy. J Vet Intern Med 2008;22:525-533.
  56. Garcia Al, Couto C, Iazbik C, Brooks MB. Post-operative bleeding in retired racing greyhounds. J Vet Intern Med 2008;24:335-355.
  57. Brooks MB, Catalfamo JL, Etter K, Brisbin A, Bustamante C. Exclusion of ABCA1 as a candidate gene for canine Scott Syndrome. J Thromb Haemostas 2008;6:1608-1610.
  58. Brooks MB. Equine coagulopathies. Vet Clin Equine 2008;24:335-355.
  59. Dereszynski DM, Center SA, Randolph JF, Brooks MB, Hadden AG, Palyada KS, McDonough SP, Messick J, Stokol T, Bischoff KL, Gluckman S, Sanders SY. Clinical and clinicopathologic features of dogs that consumed foodborne hepatotoxic aflatoxins: 72 cases (2005-2006). J Am Vet Med Assoc 2008;232:1329-1337.
  60. Wilson EM, Holcombe SJ, Lamar A, Hauptman JG, Brooks MB. Incidence of transfusion reactions and retention of procoagulant and anticoagulant factor activities in equine plasma. J Vet Intern Med 2009;23:323-328.
  61. Breuhl EL, Moore G, Brooks MB, Scott-Moncrieff JC. A prospective study of unfractionated heparin therapy in dogs with immune-mediated hemolytic anemia. J Am Anim Hosp Assoc 2009;45:125-133.
  62. O’Kelley BM, Whelan MF, Brooks MB. Factor VIII inhibitors complicating treatment of postoperative bleeding in a dog with hemophilia A. J Vet Emerg Crit Care 2009;19:381-385.
  63. Brooks MB, Randolph J, Warner K, Center S. Evaluation of platelet function screening tests to detect platelet procoagulant deficiency in dogs with Scott syndrome. Vet Clin Path 2009;38:306-315.
  64. Lunsford K, Mackin A, Langston C, Brooks MB. Pharmacokinetics of the biological effects of subcutaneous enoxaparin in dogs. J Am Anim Hosp Assoc 2009;45:261-267.
  65. Brooks M, Etter K, Catalfamo J, Brisbin A, Bustamante C, Mezey J. A genome-wide linkage scan in German shepherd dogs localizes canine platelet procoagulant deficiency (Scott syndrome) to canine chromosome 27. Gene 2010;450:70-75.
  66. Booth CJ, Brooks MB, Rockwell S. Spontaneous coagulopathy in inbred WAG/RijY rats. Comparative Med 2010;60:25-30.
  67. Yaxley PE, Beal MW, Jutkowitz LA, Hauptman G, Brooks MB, Hale AS, Parr A. Comparative stability of canine and feline hemostatic proteins in freeze-thaw cycled fresh frozen plasma. J Vet Emerg Crit Care 2010;20:472-478.
  68. Booth CJ, Brooks MB, Rockwell S, Murphy JW, Rinder HM, Zelterman D, Paidas MJ, Compton SR, Marks PW. WAG-F8m1Ycb rats harboring a Factor VIII mutation provide a new animal model for hemophilia A. J Thromb Haemostas 2010;8:2472-2477.
  69. Sharpe KS, Center SA, Randolph JF, Brooks MB, Warner KL, Stokol TS, Barr, SC, Flaminio MJ. Influence of ultralow-dose aspirin on platelet impedance aggregometry and P-selectin expression in clinically healthy dogs. Am J Vet Res 2010;71:1294-1301.