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Department of Molecular Medicine


Maurine Linder

M. Linder

Professor and Chair

Department of Molecular Medicine
College of Veterinary Medicine
Cornell University
Ithaca, New York 14853
Office: (607) 253-3893
Lab: (607) 253-3653
Fax: (607) 253-3659
E-mail:  mel237@cornell.edu


 

Research Interests

Our research addresses the mechanism and consequences of protein S-palmitoylation, a reversible posttranslational modification of proteins that regulates membrane association, protein trafficking, and protein stability.  Discovered in 2002, the DHHC (Asp-His-His-Cys) protein S-acyltransferases are responsible for palmitoylation of proteins on the cytoplasmic leaflet of cell membranes. Our recent studies have revealed the catalytic mechanism of DHHC proteins and current work is focused on understanding how DHHC proteins are regulated by  posttranslational modifications and oligomerization. 

We also have a longstanding interest in lipidation of cell signaling proteins and we have recently identified an alternative CaaX processing pathway for Cdc42 and Ral GTPases. Work is ongoing to elucidate how the alternatively processed isoforms bypass conventional CaaX processing and how they are functionally distinct from the conventionally processed isoforms.

A third project is to determine the molecular mechanisms that underlie a syndromic form of X-linked intellectual disability caused by mutations in the ZDHHC9 gene.  The objectives are to identify the substrates of DHHC9 by comparing the palmitoylomes of wild type and ZDHHC9 knockout mice and determine if ZDHHC9 knockout mice display altered behaviors in assays of cognitive, sensory, and motor functions.


Education

  • Ph.D. - 1987   Molecular and Cell Biology, School of Medicine, University of Texas at Dalla, TX
  • Internship - 1977   Medical Technology Program, St. Joseph Mercy Hospital, MI
  • B.Sc. - 1976   Medical Technology (cum laude), Michigan State University


Professional Experience

  • 2009-present   Professor and Chair, Department of Molecular Medicine, Cornell University
  • 2006-2009   Professor, Department of Cell Biology and Physiology, Washington University in St. Louis
  • 1999-2006   Associate Professor, Department of Cell Biology and Physiology, Washington University
  • 1993-1999   Assistant Professor, Department of Cell Biology and Physiology, Washington University
  • 1991-1993   Instructor, Department of Pharmacology, University of Texas, Southwestern Medical Center
  • 1989-1991   Assistant Instructor, Department of Pharmacology, University of Texas, Southwestern Medical Center
  • 1987-1989   Research Fellow, Department of Pharmacology, University of Texas, Southwestern Medical Center

Honors and Awards

  • 2009   Fellow, American Association for the Advancement of Science (AAAS) 
  • 2001-2004   American Heart Association Established Investigator

Professional Society Memberships

  • American Society for Cell Biology
  • American Society for Biochemistry and Molecular Biology
  • American Society for Pharmacology and Experimental Therapeutics


Professional Service

  • 2013-present   Editorial Board, Journal of Biological Chemistry
  • 2006-2013   ASBMB Publications Committee
  • 2004-2008   Biomedical Research Training Grant Study Section (NIH)
  • 2000   Co-chair, FASEB Conference on Lipid Modifications of Proteins
  • 1999-2000   Molecular Signaling Study Committee, American Heart Association
  • 1997-2002   Editorial Board, Journal of Biological Chemistry

 

Selected Publications

  1. Lai, J., and Linder, M.E. (2013) Oligomerization of DHHC protein S-acyltransferases.  J. Biol. Chem. 288:22862-22870.
  2. Nishimura, A., and Linder, M.E. (2013) Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding.  Mol. Cell. Biol. 33:1417-1429.
  3. Jennings, B.C., and Linder, M.E. (2012) DHHC protein S-acyltransferases use a similar ping-pong kinetic mechanism but display different acyl-CoA specificities.  J. Biol. Chem. 287:7236-7245.
  4. Swarthout, J.T., Lobo, S., Farh, L., Croke, M., Greentree, W.K., Deschenes, R.J., and Linder, M.E. (2005) DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.  J. Biol. Chem. 280:31141-31148.
  5. Lobo, S., Greentree, W.K., Linder, M.E., and Deschenes, R.J. (2002) Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae.  J. Biol. Chem. 277:41268-41273.

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