Department of Microbiology and Immunology


Dr. Schat

Emeritus Professor of Avian Virology and Immunology / Graduate School Professor

Cornell University College of Veterinary Medicine
C4 185 Veterinary Medical Center
E-mail: kas24@cornell.edu
Phone: 607-253-4032

DVM (Utrecht The Netherlands) PhD (Cornell University)

Karel A. Schat

Dr. Schat is a Professor Emeritus in the Department of Microbiology and Immunology. He received the DVM degree from the State University, Utrecht, The Netherlands in 1970, and his PhD from Cornell University in 1978 studying virology. Since 1978, he has held successive positions at the College of Veterinary Medicine, Cornell University. Throughout his career he has obtained continuous extramural funding to study avian virology and especially Marek's disease and recently chicken infectious anemia virus. From 2006 to 2010, he has been studying the pathogenesis of infection with highly pathogenic avian influenza H5N1 strains in a joint project between the Australian Animal Health Laboratory (AAHL) of the CSIRO Livestock Industries, the CDC, and the College of Veterinary Medicine. This research is conducted in the high containment facilities of AAHL in Australia (details).

He received the Pfizer Award for Excellence in Poultry Research at the 136th Annual Convention of the AVMA in New Orleans, July, 1999, and the Merck Award for Achievement in Poultry Science at the 98th Annual meeting of the Poultry Science Association in Auburn, August, 2005. In 2013 he was inducted as an inaugural member of the Hall of Honour of the World Veterinary Poultry Association.

Research Interests | Graduate Fields | Lab Members |Selected References

Research Interests

Virology, immunology, and molecular biology of Marek's disease virus, chicken infectious anemia virus, and avian influenza. Pathogenesis of Mycoplasma gallisepticum infection in house finches (Carpodacus mexicanus). Avian virology and avian immunology in general.

Graduate Fields

  • Comparative Biomedical Sciences
  • Immunology and Infectious Disease

Virology, immunology, and molecular biology of Marek's disease virus, chicken infectious anemia virus, and avian influenza. Pathogenesis of Mycoplasma gallisepticum infection in house finches (Carpodacus mexicanus). Avian virology and avian immunology in general. West Nile virus and evolution of MHC in American crows.

Graduate Fields

  • Comparative Biomedical Sciences
  • Immunology and Infectious Disease

 

Lab Members

Keila Dhondt, Research Associate

 

Selected References

  • Schat, K.A., N. Rodrigo da Silva Martins, P.H. O'Connell, and M.S. Piepenbrink. Immune complex vaccines for chicken infectious anemia virus. Avian Dis. 55:90-96. 2011.
  • Spatz, S.J. and K.A. Schat. Comparative genomic sequence analysis of the Marek’s disease vaccine strain SB-1. Virus genes 42:331-338. 2011.
  • Grodio, J.L., D.M. Hawley, E.E. Osnas, D.H. Ley, K.V. Dhondt, A.A. Dhondt, and K.A. Schat. Pathogenicity and immunogenicity of three Mycoplasma gallisepticum isolates in house finches (Carpodacus mexicanus). Vet. Microbiol. 155:53-61, 2012.
  • Schat, K.A., J. Bingham, J. Butler, L-M. Chen, S. Lowther, T. Crowley, R.J. Moore, R.O. Donis, and J.W. Lowenthal. Role of position 627 of PB2 and the multibasic cleavage site of the hemagglutinin in the virulence of H5N1 avian influenza virus for chickens and ducks. Plos One 7:e30960. 2012.
  • Dhondt, A.A., S.L. States, K.V. Dhondt and K.A. Schat. Understanding the origin of seasonal epidemics of mycoplasmal conjunctivitis. J. Evol. Biol. 81:996-1003. 2012.
  • St. Paul, M., S. Paolucci, N. Barjesteh, R.D. Wood, K.A. Schat, S. Sharif. Characterization of chicken thrombocyte responses to Toll-like receptor ligands. PLoS One, 7(8):e43381. 2012.
  • Sunarto, A., C. Liongue, K.A. McColl, M.M. Adams, D. Bulach, M.S. Crane, K.A. Schat, B. Slobedman, A.C. Barnes, A.C. Ward, and P.J. Walker. Koi herpesvirus encodes and expresses a functional interleukin-10 gene (khvIL-10). J. Virol. 86:11512-11520. 2012.
  • Dhondt A.A., K.V. Dhondt, W.M. Hochachka, and K.A. Schat. Can American goldfinches function as reservoirs for Mycoplasma gallisepticum? J. Wildlife Dis. 49:49-54. 2013.
  • Schat, K.A., M.S. Piepenbrink, E.L. Buckles, Y.H. Schukken, and K.W. Jarosinski. Importance of differential expression of Marek’s disease virus gene pp38 for the pathogenesis of Marek’s disease. Avian Dis. 57:503-508. 2013.
  • Haq, K., K.A. Schat, and S. Sharif. Immunity to Marek’s disease: Where are we now? Dev. Comp. Immunol. 41:439-446. 2013
  • Bulbule, N.R., K.D. Mandakhalikar, S.S. Kapgate, S.G. Kshirsagar, K.A. Schat, and M.M. Chawak. Role of chicken astroviruses as a causative agent of gout in commercial broilers in India. Avian Pathol. 42:464-473. 2013.
  • Grodio, J. L., D. H. Ley, K. A. Schat, and D. M. Hawley. Chronic Mycoplasma conjunctivitis in house finches: host antibody response and M gallisepticum VlhA expression. Vet. Immunol. Immunopathol. 154:129-137. 2013.
  • Tyack, S.G., K.A. Jenkins, T.E. O’Neil, T.G. Wise, K.R. Morris, M.P. Bruce, S. McLeod, A.J. Wade, J. McKay, R.J. Moore, K.A. Schat, J.W. Lowenthal and T. J. Doran. A new method for producing transgenic birds via direct in vivo transfection of primordial germ cells. Transgenic Res. 22: 1257-1264. 2013.
  • Sunarto, A., K.A. McColl, M.St.J. Crane, K.A. Schat, B. Slobedman, A.C. Barnes, and P.J. Walker. Characteristics of cyprinid herpesvirus 3 in different phases of infection: implications for disease transmission and control. Virus Res. 188:45-54. 2014.
  • Schat, K.A. and H.N. Erb. Lack of evidence that avian oncogenic viruses are infectious for humans: A review. Avian Dis. 58:345–358. 2014.

 

Recent Book Chapters and Books:

  • Schat, K.A. and V.L. van Santen. Chicken infectious anemia. In: Diseases of Poultry 13th ed. D.E. Swayne J.R. Glisson, L.R. McDougald, L.K. Nolan, D.L. Suarez, and V. Nair, eds. Wiley-Blackwell, Ames, IA, pp 248-264+276-284. 2013.
  • Schat, K.A. and L.W. Woods. Chicken infectious anemia virus and other circovirus infections. In: Diseases of Poultry 13th ed. D.E. Swayne, J.R. Glisson, L.R. McDougald, L.K. Nolan, D.L. Suarez, and V. Nair, eds. Wiley-Blackwell, Ames, IA, p247 + 276. 2013.
  • Schat, K.A. and V. Nair. Marek’s disease. In: Diseases of Poultry 13th ed. D.E. Swayne, J.R. Glisson, L.R. McDougald, L.K. Nolan, D.L. Suarez, and V. Nair, eds. Wiley-Blackwell, Ames, IA, pp 515-552 + 623-644. 2013
  • Adelman, J., D.R. Ardia, D.R., K.A. Schat. Ecoimmunology. In: Avian Immunology 2nd ed. K.A. Schat, B. Kaspers and P. Kaiser, eds. Elsevier. pp 391-412. 2014
  • Wigley, P., P. Barrow, and K.A Schat. The reproductive immune system. In: 2nd ed. K.A. Schat, B. Kaspers and P. Kaiser, eds. Elsevier. pp 265-274. 2014.
  • Kaspers, B., P. Kaiser, and K.A. Schat. The mucosal immune system. In: Avian Immunology 2nd ed. K.A. Schat, B. Kaspers and P. Kaiser, eds. Elsevier. pp 223-226. 2014
  • Schat, K.A. and M.A. Skinner. Immunosuppressive diseases and immune evasion. In: Avian Immunology 2nd ed. K.A. Schat, B. Kaspers and P. Kaiser, eds. Elsevier. pp 275-298. 2014.
  • Smyth, J.A. and K.A. Schat. Virus-induced immunosuppression: chicken infectious anemia. In: Immunosuppressive diseases of poultry. I.M. Gimeno, ed. Servet, Zaragosa, Spain, pp 91-121, 2013 (the book is also available in Spanish).
  • Schat, K.A. Vaccines and vaccination practices: key to sustainable animal production. In: Elsevier’s Encyclopedia of Agriculture and Food Systems. N.K. Van Alfen, Ed. Elsevier, London, pp 315-332. 2014.
  • Schat, K.A., B. Kaspers, and P. Kaiser, Eds. Avian Immunology 2nd ed. Elsevier. pp 275-298. 2014.