Harness Racing  

Advancing the health and well-being of animals and people


Publications

 

Publications can also be found online at PubMed

  • Fortier LA*, Mac Harg MA.  Topical use of 5-fluorouracil for treatment of squamous cell carcinoma of the external genitalia of horses:  11 cases (1988-1992).  J Am Vet Med Assoc 1994; 205:1183-1185.
  • Fortier LA, Foerner JJ, Nixon AJ.  Arthroscopic removal of axial osteochondral fragments of the plantar/palmar proximal aspect of the proximal phalanx in horses: 119 cases (1988-1992).  J Am Vet Med Assoc 1995; 206:71-74.
  • Fortier LA*, Fubini SL, Flanders JA, Divers TJ.  The diagnosis and surgical correction of congenital portosystemic vascular anomalies in two calves and two foals.  Vet Surg 1996; 25:154-160.
  • Fortier LA, Nixon AJ, Mohammed HO, Lust G.  Altered biological activity of equine chondrocytes cultured in a three-dimensional fibrin matrix and supplemented with transforming growth factor B1.  Am J Vet Res 1997; 58:66-70.
  • Fortier LA, Nixon AJ.  Distributional changes in substance P nociceptive fiber patterns in naturally osteoarthritic articulations.  J Rheumatol 1997; 24:524-530.
  • Cable CS, Rebhun WC, Fortier LA*.  Cholelithiasis and cholecystitis in a dairy cow.  J Am Vet Med Assoc 1997; 211:899-900.
  • Fortier LA, Brofman PJ, Nixon AJ, Mohammed HO.  Disparate chondrocyte metabolism in three-dimensional fibrin cultures derived from autogenous or commercially manufactured fibrinogen.  Am J Vet Res 1998; 59:514-520
  • Fortier LA, Nixon AJ, Williams J, Cable CS.  Isolation and chondrocytic differentiation of equine bone-marrow-derived mesenchymal stem cells.  Am J Vet Res 1998; 59:1182-1187.
  • Fortier LA, Lust G, Mohammed HO, Nixon AJ.  Coordinate upregulation of cartilage matrix synthesis in fibrin cultures supplemented with exogenous insulin-like growth factor-I.  J Orthop Res 1999; 17:467-474.
  • Nixon AJ, Fortier LA, Williams J, Mohammed H.  Enhanced repair of extensive articular defects by insulin-like growth factor-I laden fibrin composites.  J Orthop Res 1999; 17:475-487.
  • Fortier LA, Nixon AJ, Ducharme NG, Mohammed HO, Yeager A.  Tenoscopic examination and proximal annular ligament desmotomy for treatment of equine “complex” digital sheath tenosynovitis.  Vet Surg 1999; 28:429-435. 
  • Fortier LA, Balkman CE, Sandell LJ, Ratcliffe A, Nixon AJ.  Insulin-like growth factor-I gene expression patterns during spontaneous repair of acute articular cartilage injury.  J Orthop Res 2001; 19:720-728.
  • Worster AA, Brower-Toland BD, Fortier LA, Bent SJ, Williams J, Nixon AJ.  Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor-beta1 in monolayer and insulin-like growth factor-I in a three-dimensional matrix.  J Orthop Res 2001; 19:738-749.
  • Fortier LA, Nixon AJ, Lust G.  Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-I.  Am J Vet Res 2002; 63:301-305.
  • Fortier LA, Mohammed HO, Lust G, Nixon AJ.  Insulin-like growth factor-I enhances cell-based repair of articular cartilage. J Bone Joint Surg Br 2002; 84:276-288.
  • Goodrich LR, Nixon AJ, Fubini SL, Ducharme NG, Fortier LA, Warnick LD, Ludders JW.  Epidural morphine and detomidine decreases postoperative hindlimb lameness in horses after bilateral stifle arthroscopy.  Vet Surg 2002; 31:232-239.
  • Textor JA, Nixon AJ, Fortier LA.  Tenoscopic release of the equine carpal canal.  Vet Surg 2003; 32:278-284.
  • Fortier LA*, Deak, MM, Semevolos SA, Cerione RA.  Insulin-like growth factor-I diminishes the activation status and expression of the small GTPase Cdc42 in articular chondrocytes.  J Orthop Res 2004; 22:436-445.
  • Nixon AJ, Fortier LA, Goodrich LR, Ducharme NG.  Arthroscopic reattachment of osteochondritis dissecans lesions using resorbable polydioxanone pins.  Equine Vet J 2004; 36:376-383.
  • Fortier LA*, Gregg AJ, Erb HN, Fubini SL.  Caprine obstructive urolithiasis: requirement for 2nd surgical intervention and mortality after percutaneous tube cystostomy, surgical tube cystostomy, or urinary bladder marsupialization.  Vet Surg 2004; 33:661-667.
  • Fortier LA*, Kornatowski MA, Mohammed HO, Jordan MT, O’Cain LC, Stevens, WB.  Age-related changes in serum insulin-like growth factor-I, insulin-like growth factor-I binding protein-3, and articular cartilage structure in Thoroughbred horses. Equine Vet J 2005; 37:37-42.
  • Fortier LA*.  Indications and techniques for tenoscopic surgery of the digital flexor tendon sheath.  Equine Vet Educ 2005; 17:218-224.
  • Fortier LA*.  Stem Cells: classifications, controversies and clinical applications.  Vet Surg 2005; 34:415-423. Invited Manuscript.
  • Fortier LA*.  Systemic therapies for joint disease in horses. Vet Clin North Am Equine Pract 2005;21:673-690
  • Fortier LA*, Nixon AJ.  New surgical treatments for osteochondritis dissecans and subchondral bone cysts.  Vet Clin North Am Equine Pract 2005; 21:547-557. Invited Manuscript.
  • Gratz KR, Wong VW, Chen AC, Fortier LA, Nixon AJ, Sah RL. Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilage.  J Biomech 2006; 39:138-146.
  • Gregg AJ, Fortier LA*, Mohammed HO, Mayr KG, Miller BJ, Haupt JL.  Assessment of the catabolic effects of interleukin-1beta on proteoglycan metabolism in equine cartilage cocultured with synoviocytes.  Am J Vet Res 2006; 67:957-962.
  • Fortier LA*, Miller BJ.  Signaling through the small G-protein Cdc42 is involved in insulin-like growth factor-I resistance in aging articular chondrocytes.  J Orthop Res 2006; 24:1765-1772.
  • Semevolos SA, Nixon AJ, Fortier LA, Strassheim ML, Haupt J. Age-related expression of molecular regulators of hypertrophy and maturation in articular cartilage.  J Orthop Res 2006; 24:1773-1781.
  • Schnabel LV, Mohammed HO, Miller BJ, McDermott WG, Jacobson MS, Santangelo KS, Fortier LA*.  Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons.  J Orthop Res 2007; 25:230-240.
  • Fortier LA*, Schnabel LV, Mohammed HO, Mayr KG.  Assessment of cartilage degradation effects of matrix metalloproteinase-13 in equine cartilage cocultured with synoviocytes.  Am J Vet Res 2007; 68:379-384.
  • Boehm AK, Seth M, Mayr KG, Fortier LA*.  Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an age-dependent manner in equine articular chondrocytes.  Arthritis and Rheum 2007; 56:2335-2343.
  • Watts AE, Fortier LA, Nixon AJ, Ducharme NG. A technique for internal fixation of scapulohumeral luxation using scapulohumeral tension sutures in three alpacas and one miniature steer. Vet Surg 2008; 37(2):161-165.
  • Fortier LA*, Smith RK. Regenerative medicine for tendinous and ligamentous injuries of sport horses.  Vet Clin North Am Equine Pract 2008; 24(1):191-201. Invited Manuscript.
  • Schnabel LV, Sonea HO, Jacobson MS, Fortier LA*. Effects of platelet rich plasma and acellular bone marrow on gene expression patterns and DNA content of equine suspensory ligament explants cultures. Equine Vet J 2008: 40(3):260-265.
  • Fischer BL, Ludders JW, Asakawa M, Fortier LA, Fubini SL, Nixon AJ, Radcliffe RM, Erb HN. A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy. Vet Anaesth Analg 2009; 36(1):67-76.
  • Novakofski KD, Boehm A, Fortier L*.  The small GTPase Rho mediates articular chondrocyte phenotype and morphology in response to interleukin-1α and  insulin-like growth factor-1.  J Orthop Res 2009; 27(1):58-64.
  • Getgood A, Brooks R, Fortier L, Rushton N. Articular cartilage tissue engineering: today’s research, tomorrow’s practice? J Bone Joint Surg Br 2009; 91(5):565-576.
  • Ducharme NG, Fortier LA, Kraus MS, Hobo S, Mohammed HO, McHugh M, Hackett RP, Soderholm LV, Mitchell LM. Effect of tart cherry juice blend on exercise-induced muscle damage in horses. Am J Vet Res 2009; 70(6):758-763.
  • Furman SM, Fortier LA, Schnabel LV, Krotscheck U. Trochlear block recession in an alpaca with traumatic lateral patellar luxation. Vet Surg 2009; 38(3):421-425.
  • McCarrel T, Fortier LA*. Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthop Res 2009; 27(8):1033-1042.
  • Watts AE, Fortier LA, Nixon AJ, Ducharme NG. A Technique for laser-facilitated equine pastern arthrodesis using parallel screws inserted in lag fashion. Vet Surg 2010; 39(2):244-253.
  • Radcliffe CH, Flaminio MJ, Fortier LA*. Temporal analysis of equine bone marrow aspirate during establishment of putative mesenchymal progenitor cell populations. Stem Cells Dev 2010; 19(2):269-282.
  • Fortier LA*, Motta T, Greenwald RA, Diver TJ, Mayr KG. Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1α and MMP-13-induced catabolic gene responses. J Orthop Res 2010; 28(4):522-528.
  • Fortier LA*, Potter HG, Rickey LJ, Schnabel LV, Foo LF, Chong LR, Stokol T, Cheetham J, Nixon AJ. Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model. J Bone Joint Surg Am 2010; 92(10):1927-1937.
  • Cheetham J, Riordan AS, Mohammed HO, McIlwraith CW, Fortier LA*. Relationships between race earnings and horse age, sex, gait, track surface and number of race starts for Thoroughbred and Standardbred race horses in North America. Equine Vet J 2010; 42(4):346-350.
  • Cole B, Seroyer ST, Filardo G, Bajaj S, Fortier LA*. Platelet–Rich Plasma: Where Are We Now and Where Are We Going. Sports Health, 2010; 2:203-210.
  • Schnabel LV, Papich MG, Watts AE, Fortier LA*. Orally administered doxycycline accumulates in synovial fluid compared to plasma. Equine Vet J 2010; 42(3):208-212.
  • Rodeo SA, Delos D, Weber A, Ju X, Cunningham, ME, Fortier L, Maher S. What’s new in orthopaedic research? J Bone Joint Surg Am 2010; 92(14):2491-2501. Invited Manuscript.
  • Cook JL, Evans R, Conzemius MG, Lascelles BDX, McIllwraith CW, Pozzi A, Clegg P, Innes J, Schulz K, Houlton J, Fortier L, Cross AR, Hayashi K, Kapatkin A, Brown DC, Stewart A. Proposed definitions and criteria for reporting time frame, outcome, and complications for clinical orthopedic studies in veterinary medicine.  Vet Surg 2010; 39(8):905-908.
  •   Fortier LA*, Travis AJ. Stem cells in veterinary medicine. Stem Cell Res Ther 2011; 2(1):9. Invited Manuscript.
  • Hackett CH, Flaminio MJ, Fortier LA*. Analysis of CD14 expression levels in putative mesenchymal progenitor cells isolated from equine bone marrow. Stem Cells Dev. 2011; 20(4):721-735.
  • Hurtig MB, Buschmann MD, Fortier LA, Hoemann CD, Hunziker EB. Jurvelin JS, Mainil-Varlet P, McIlwraith CW, Sah RL, Whiteside RA. Pre-clinical studies for cartilage repair: Recommendations from the International Cartilage Repair Society. Cartilage 2011; 2(2):137-152.
  • Gulotta LV, Wiznia D, Cuningham M, Fortier LA, Maher S, Rodeo SA. What’s new in orthopaedic research. J Bone Joint Surg Am 2011; 93(22):2136-2141. Invited Manuscript.
  • Hackett CH, Fortier LA*. Embryonic stem cells and iPS cells: sources and characteristics. Vet Clin North Am Equine Pract 2011; 27(2):233-242. Invited Manuscript.
  • Getgood A, Henson F, Brooks R, Fortier LA, Rushton N. Platelet-rich plasma activation in combination with biphasic osteochondral scaffolds-conditions for maximal growth factor production. Knee Surg Sports Traumatol Arthrosc 2011; 19(11):1942-1947.
  • Sundman EA, Cole BJ, Fortier LA*. Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma. Am J Sports Med 2011; 39(10):2135-2140.
  • Fortier LA*, Barker JU, Strauss EJ, McCarrel TM, Cole BJ.  The role of growth factors in cartilage repair. Clin Orthop Relat Res 2011; 469(10):2706-2715.
  • Sparks HD, Nixon AJ, Fortier LA, Mohammed HO. Arthroscopic reattachment of osteochondritis dissecans cartilage flaps of the femoropatellar joint: long-term results. Equine Vet J 2011; 43(6):650-659.
  • McIlwraith CW, Fortier LA, Frisbie DD, Nixon AJ. Equine models of articular cartilage repair. Cartilage 2011; 2(4):317-326. Invited Manuscript.
  • Fortier LA*, Cole BJ. The effects of platelet rich plasma on cartilage: Basic science and clinical application. Op Tech Sports Med.  2011; 19(3):154-159.
  • Novakofski KD, Torre CJ, Fortier LA*. Interleukin-1a, -6, and -8 decrease Cdc42 activity resulting in loss of articular chondrocyte phenotype. J Orthop Res 2012; 30(2):246-251. 
  • Boswell SA, Cole BJ, Sundman EA, Karas V, Fortier LA*. Platelet rich plasma: a milieu of bioactive factors. Arthroscopy 2012; 28(3):429-439.
  • Fortier LA*. Making progress in the what, when and where of regenerative medicine for our equine patients. Equine Vet J 2012;44(5):511-512. Invited Editorial Commentary.
  • Ortved K, Nixon AJ, Mohammed HO, Fortier LA. Treatment of subchondral cystic lesions of the medial femoral condyle of mature horses with growth factor enhanced chondrocyte grafts: A retrospective study of 49 cases. Equine Vet J 2012; 44(5):606-613.
  • Schnabel LV, Abratte CM, Schimenti JC, Southard TL, Fortier LA*. Genetic background affects induced pluripotent stem cell generation. Stem Cell Res Ther 2012; 3(4):30.
  • Schnbael LV, Papich MG, Divers TJ, Altier C, Aprea MS, McCarrel TM, Fortier LA*. Pharmacokinetics and distribution of minocycline in mature horses after oral administration of multiple doses and comparison with minimum inhibitory concentrations. Equine Vet J 2012; 44(4):453-458.
  • Hackett CH, Greve L, Novakofski KD, Fortier LA*. Comparison of gene-specific DNA methylation patterns in equine induced pluripotent stem cell lines with cells derived from equine adult and fetal tissues. Stem Cells Dev 2012; 21(10):1803-1811.
  • Fortier LA*, Cole BJ, McIlwraith CW. Science and animal models of marrow stimulation for cartilage repair. J Knee Surg 2012; 25(1):3-8. Invited Manuscript.
  • McCarrel TM, Minas T, Fortier LA*. Optimization of leukocyte concentration in platelet-rich plasma for the treatment of tendinopathy. J Bone Joint Surg 2012; 94(19):e1431-1438.
  • Getgood A, Henson F, Skelton C, Herrera E, Brooks R, Fortier LA, Rushton N. The augmentation of collagen/glycosaminoglycan biphasic osteochondral scaffold with platelet rich plasma and concentrated bone marrow aspirate for osteochondral defect repair in sheep: A pilot study. Cartilage 2012; 3(4):351-363.
  • Rodeo SA, Ma R, Moran C, Fortier LA, Frawley RJ, Cunningham M, Maher S. What’s new in orthopaedic research. J Bone Joint Surg Am 2012; 94(24):2289-2295. Invited Manuscript.
  • Ross KA, Williams RM, Schnabel LV, Mohammed HO, Potter HG, Bradica G, Castiglione E, Pownder SL, Satchell PW, Saska RA, Fortier LA*. Comparison of three methods to quantify repair cartilage collagen orientation. Cartilage 2013; 4(2):111-120.
  • Papich MG, Davidson GS, Fortier LA. Doxycycline concentration over time after storage in a compounded veterinary preparation. J Am Vet Med Assoc 2013; 242(12):1674-1678.
  • Koff MF, Shah P, Pownder S, Romero B, Williams R, Gilbert S, Maher S, Fortier LA, Rodeo SA, Potter HG. Correlation of meniscal T2* with multiphoton microscopy, and change of articular cartilage T2 in an ovine model of meniscal repair. Osteo Cart 2013; 21(8):1083-1091.
  • Smyth NA, Murawski CD, Fortier LA*, Cole BJ, Kennedy JG. Platelet-rich plasma in the pathologic processes of cartilage: review of basic science evidence. Arthroscopy 2013; 29(8):1399-1409.
  • Haleem AM, Smyth NA, Kennedy JG, Fortier LA*. Update on cartilage regeneration and clinical applications of tissue engineering in the management of cartilage defects. Ortho Know Online J July 1, 2013; Invited Manuscript.
  • Schnabel LV, Fortier LA, McIlwraith C, Nobert KM. Therapeutic use of stem cells in horses: Which type, how and when? Vet J 2013; 197(3):570-577. Invited Review.
  • Abrams GD, Mall NA, Fortier LA, Roller BL, Cole BJ. BioCartilage: Background and operative technique. Op Tech in Sports Med 2013; 21(2):116-124.
  • Rodeo SA, Ma R, Frawley R, Cunningham ME, Fortier LA, Maher S.  What’s new in orthopaedic research?  J Bone Joint Surg Am. 2013; 95(23):2158-2164.
  • Abrams GD, Frank RM, Fortier LA, Cole BJ.  Platelet-rich plasma for articular cartilage repair.  Sports Med Arthrosc. 2013; 21(4):213-219.
  • Sundman EA, Cole BJ, Karas V, Della Valle CJ, Tetreault MW, Mohammed HO, Fortier LA*. The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis. Am J Sports Med 2014; 42(1):35-41.
  • Boswell SG, Schnabel LV, Mohammed HO, Sundman EA, Minas T, Fortier LA*. Increasing platelet concentrations in leukocyte-reduced platelet rich plasma decrease collagen gene synthesis in tendons. Am J Sports Med 2014; 42(1):42-49.
  • Schnabel LV, Pezzanite LM, Antczak DF, Felippe MJB, Fortier LA*. Equine bone marrow-derived mesenchymal stromal cells are heterogeneous in MHC class II expression and capable of inciting an immune response in vitro. Stem Cells Res Ther 2014; 5(1):13.
  • Novakofski KD, Williams RM, Fortier LA, Mohammed HO, Zipfel WR, Bonassar LJ.  Identification of cartilage injury using quantitative multiphoton microscopy.  Osteoarthritis Cartilage. 2014; 22(2):355-362.
  • Maher MC, Schnabel LV, Cross JA, Papich MG, Divers TJ, Fortier LA*. Plasma and synovial fluid concentration of doxycycline following low-dose, low-frequency administration and resultant inhibition of MMP-13 from interleukin-stimulated equine synoviocytes. Equine Vet J. 2014; 46(2):198-202.
  • McCarrel TM, Mall NA, Lee AS, Cole BJ, Fortier LA. Considerations for the use of platelet-rich plasma in orthopaedics.  Sports Med 2014; Epub ahead of print.
  • Scharf AM, Hackett CH, Fortier LA*. CD14 positive cell selection enriches marrow-derived Mesenchymal progenitor cells for chondrogenic differentiation. Cartilage 2013; In review.
  • Suter KK, Payne KA, Yao V, Fortier LA, Chu CR. In vitro chondrogenic potential of concentrated equine bone marrow aspirate. Tissue Engineering 2011; In review.
  • Novakofski KD, Williams RW, Fortier LA, Silverberg JL, Zipfel WR, Bonassar LJ. Compressive cartilage injury propagates along collagen fibers, as quantified with multiphoton microscopy. J Orthop Res. 2012; In review.
  • Lang HM, Schnabel LV, Fortier LA. Needle size affects the viability of equine bone marrow-derived mesenchymal stem cells in vivo. Vet Surg 2013; In review.
  • Smith RKW, Garvican ER, Fortier LA. The use of regenerative medicine in horses: the current state of play. Regenerative Medicine 2013; In review. Invited Review.
  • Lee CH, Mao J, Fortier LA.  Endogenous cells regenerate knee meniscus upon spatiotemporal protein delivery.  Science 2014; In review.
  • Cole BJ, Fortier LA. The role of platelet-rich plasma in articular cartilage injury and disease. J Knee Surg. 2014. In review.
  • Wilson B, Novakofski KD, Donocoff RS, Liang YXA, Fortier LA. Telomerase activity in articular chondrocytes is lost after puberty. Cartilage 2014 Submitted.