photo of student with pony  

Advancing the health and well-being of animals and people


Bud Tennant

Bud C. Tennant
Cornell University
College of Veterinary Medicine
C2 009VMC, Box 33
Ithaca, NY 14853
bct3@cornell.edu

Selected Publications


Richardson FC, Tennant BC, Meyer DJ, Richardson KA, Mann PC, McGinty GR, Wolf JL, Zack PM, Bendele RA: An evaluation of the toxicities of 2'-fluorouridine and 2'-fluorocytidine-HCl in F344 rats and woodchucks (Marmota monax). TOXICOL PATHOL 27 (6): 607-617, 1999.

Concannon PW, Castracane VD, Rawson RE, Tennant BC: Circannual changes in free thyroxine, prolactin, testes, and relative food intake in woodchucks, Marmota monax. AM J PHYSIOL 277 (5 Pt 2) (Regulatory Integrative Comp. Physiol. 46): R1401-R1409, 1999.

Menne S, Tennant BC: Unraveling hepatitis B virus infection of mice and men (and woodchucks and ducks). NATURE MED 5 (10): 1125-1126, 1999.

Korba BE, Cote P, Hornbuckle W, Schinazi R, Gerin JL and Tennant BC: Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks. ANTIVIRAL RES 45 (1): 19-32, 2000.

Bilbao R, Gerolami R, Bralet MP, Qian C, Tran PL, Tennant BC, Prieto J, Brechot C: Transduction efficacy, antitumoral effect, and toxicity of adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir therapy of hepatocellular carcinoma: the woodchuck animal model. CANCER GENE THER 7 (5): 657-662, 2000.

Hostetler KY, Beadle JR, Hornbuckle WE, Bellezza CA, Tochkov IA, Cote PJ, Gerin JL, Korba BE, Tennant BC: Antiviral activities of oral 1-0-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection. ANTIMICROB AGENTS CHEMO 44 (7): 1964-1969, 2000.

Sitterlin D, Bergametti F, Tiollais P, Tennant BC, Transy C: Correct binding of viral X protein to UVDDB-p127 cellular protein is critical for efficient infection by hepatitis B viruses. ONCOGENE 7 (38): 4427-4431, 2000.

Cote PJ, Toshkov I, Bellezza C, Ascenzi M, Roneker C, Graham LA, Baldwin BH, Gaye K, Nakamura I, Korba BE, Tennant BC, Gerin JL: Temporal pathogenesis of experimental neonatal woodchuck hepatitis virus infection: Increased initial viral load and decreased severity of acute hepatitis during the development of chronic viral infection. HEPATOLOGY 32 (4 Pt 1): 807-817, 2000.

Tennant BC, Gerin JL: The woodchuck model of hepatitis B virus infection. ILAR J 42: 89-102, 2001.

Peek SF, Cote PJ, Jacob JR, Toshkov IA, Hornbuckle WE, Baldwin BH, Wells FV, Chu CK, Gerin JL, Tennant BC, Korba BE: Antiviral activity of Clevudine [L-FMAU, 1-(2-fluoro-5-methyl-ß,L-arabinofuranosyl) uracil] against WHV replication and gene expression in chronically infected woodchucks (M. monax). HEPATOLOGY 33 (1): 254-266, 2001.

Nakamura I, Nupp JT, Cowlen M, Hall WC, Tennant BC, Casey JL, Gerin JL, Cote PJ: Pathogenesis of experimental neonatal woodchuck hepatitis virus infection: Chronicity as an outcome of infection is associated with a diminished acute hepatitis that is temporally deficient for the expression of interferon gamma and tumor necrosis factor-alpha messenger RNAs. HEPATOLOGY 33 (2): 439-437, 2001.

Putzer BM, Stiewe T, Rodicker F, Schildgen O, Ruhm S, Dirsch O, Fiedler M, Damen U, Tennant BC, Scherer C, Graham FL, Roggendorf M: Large nontransplanted hepatocellular carcinoma in woodchucks: Treatment with adenovirus-mediated delivery of interleukin 12/B7.1 genes. J NATL CANCER INST 93 (6): 472-479, 2001.

Bryant, ML, Bridges EG, Placidi, L, Faraj, A, Loi AG, Pierra C, Dukhan, D, Gosselin G, I JL, Hernandez B, Juodawlkis A, Tennant BC, Korba B, Cote P, Cretton-Scott E, Schinazi RF, Sommadossi JP: Anti-HBV specific B-L-2'-deoxynucleosides. NUCLEOSIDES NUCLEOTIES NUCLEIC ACIDS 20 (4-7): 597-607, 2001.

Concannon P, Levac K, Rawson R, Tennant BC, Bensadoun A: Seasonal changes in serum leptin, food intake, and body weight in photoentrained woodchucks. AM J PHYSIOL REGUL INTEGR COMP PHYSIOL 281 (3): R951-959, 2001.

Colonno RJ, Genovesi EV, Medina I, Lamb L, Durham SK, Huang ML, Corey L, Littlejohn M, Locarnini S, Tennant BC, Rose B, Clark JM: Long-term entecavir treatment results in sustained antiviral efficacy and prolonged life span in the woodchuck model of chronic hepatitis infection. J INFECT DIS 184 (10): 1236-1245, 2001.

Tennant BC. Animal models of hepadnavirus associated hepatocellular carcinoma. In: CLINICS IN LIVER DISEASE. AM Di Bisceglie, ed. WB Saunders, Philadelphia, 5: 43-68, 2001.

Menne S, Roneker CA, Roggendorf M, Gerin JL, Cote PJ, Tennant BC: Deficiencies in the acute-phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculation. J VIROLOGY 76 (4): 1769-1780, 2002.

Menne S, Roneker CA, Korba BE, Gerin JL, Tennant BC, Cote PJ: Immunization with surface antigen vaccine alone and after treatment with 1-(2-Fluoro-5-Methyl-?-L-Arabinofuranosyl)-Uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection. J VIROLOGY 76 (11): 5305-5314, 2002.

Sahu GK, Tai PC, Chatterjee SB, Lin MH, Tennant BC, Gerin J, Shih C: Out-of-frame versus in-frame core internal deletion variants of human and woodchuck hepatitis B viruses. VIROLOGY 292: 35-43, 2002.

Menne S, Wang Y, Butler SD, Gerin JL, Cote PJ, Tennant BC: Real-time polymerase chain reaction assays for leukocyte CD and cytokine mRNAs of the Eastern woodchuck (Marmota monax). VET IMMUNOL IMMUNOPATHOL 87 (1-2): 97-105, 2002.

Bellezza CA, Concannon PW, Hornbuckle WE, Roth L, Tennant BC: The laboratory woodchuck (Marmotamonax). In: LABORATORY ANIMAL MEDICINE, 2nd ed. JG Fox, LC Anderson, FM Loew, and FW Quimby, eds. New York: Academic Press, p. 309-328, 2002.

Colonno RJ, Genovesi EV, Medina I, Lamb L, Durham SK, Huang ML, Corey L, Littlejohn M, Locarnini S, Tennant BC, Rose B, Clark JM: Long-term entecavir treatment results in sustained antiviral efficacy and prolonged life span in the woodchuck model of chronic hepatitis infection. J INFECT DIS 184 (10): 1236-1245, 2001.

Menne S, Roneker CA, Roggendorf M, Gerin JL, Cote PJ, Tennant BC: Deficiencies in the acute-phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculation. J VIROLOGY 76 (4): 1769-1780, 2002.

Menne S, Roneker CA, Korba BE, Gerin JL, Tennant BC, Cote PJ: Immunization with surface antigen vaccine alone and after treatment with 1-(2-Fluoro-5-Methyl-?-L-Arabinofuranosyl)-Uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection. J VIROLOGY 76 (11): 5305-5314, 2002.

Menne S, Wang Y, Butler SD, Gerin JL, Cote PJ, Tennant BC: Real-time polymerase chain reaction assays for leukocyte CD and cytokine mRNAs of the Eastern woodchuck (Marmota monax). VET IMMUNOL IMMUNOPATHOL 87 (1-2): 97-105, 2002.

Tatti JM, Korba BE, Stang HL, Peek S, Gerin JL, Tennant BC, Schinazi RF: Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine. ANTIVIRAL RESEARCH 55: 141-150, 2002.

Hurwitz, SJ, Tennant BC, Korba, BE, Liberman, I, Gerin, JL, and Schinazi, RF: Viral pharmacodynamic model for (-)-?-2',3'-dideoxy-5-fluoro-3'-thiacytidine (emtricitabine) in chronically infected woodchucks. ANTIVIRAL CHEM CHEMOTHER 31: 165-176, 2002.

Wang Y, Menne S, Jacob JR, Tennant BC, Gerin JL, Cote PJ: Role of type 1 versus type 2 immune responses in liver during the onset of chronic woodchuck hepatitis virus infection. HEPATOLOGY 37: 771-780, 2003.

O'Gorman MA, Sharma S, Groopman JD, Tennant BC, Tochkov IA, Schwarz KB. Decreased oxidative DNA damage and accelerated cell turnover in woodchuck hepatitis virus infected liver. HEPATOL RES 25: 254-262, 2003.

Wang Y, Menne S, Baldwin BH, Tennant BC, Gerin JL, Cote PJ: Kinetics of viremia and acute liver injury in relation to outcome of neonatal woodchuck hepatitis virus infection. J OF MED VIROLOGY 72: 406-415, 2004.

Jacob JR, Sterczer A, Toshkov IA, Yeager AE, Korba BE, Cote PJ, Buendia M-A, Gerin JL, Tennant BC: Integration of woodchuck hepatitis virus and N-myc rearrangement determine size and histologic grade of hepatic tumors. HEPATOLOGY 39: 1008-1016, 2004.

Jacob JR, Korba BE, Cote PJ, Toshkov I, Delaney WE, GerinJL, Tennant BC: Suppression of lamivudine-resistant B-domain mutants by adefovir dipivoxil in the woodchuck hepatitis virus model. ANTIVIRAL RESEARCH 63: 115-121, 2004.

Jacob JR, Lin KC, Tennant BC, Mansfield KG: GB virus B infection of the common marmoset (Callithrix jacchus) and associated liver pathology. J GEN VIROL 85: 2525-2533, 2004.

Wang Y, Jacob JR, Menne S, Bellezza CA, Tennant BC, Gerin JL, Cote PJ: Interferon-?-associated responses to woodchuck hepatitis virus infection in neonatal woodchucks and virus-infected hepatocytes. J VIRAL HEPATITIS 11: 404-417, 2004.

Tennant BC, Toshkov IA, Peek SF, Jacob JR, Menne S, Hornbuckle WE, Schinazi RD, Korba BE, Cote PJ, Gerin JL: Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection. GASTROENTEROLOGY 127: S283-S293, 2004.

Block TM, Comunale MA, Lowman M, Steel LF, Romano PR, Fimmel C, Tennant BC, London WT, Evans AA, Blumberg BS, Dwek RA, Mattu TS, Mehta AS: Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans. PROC NATL ACAD SCI USA 102: 779-74, 2005.

Menne S, Cote PJ, Korba BE, Butler SD, George AL, Tochkov IA, Delaney WE, Xiong S, Gerin JL, Tennant BC: Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. ANTIMICROB AGENTS CHEMOTHER 49: 2720-2728, 2005.

Casey J, Cote PJ, Toshkov IA, Chu CK, Gerin JL, Hornbuckle WE, Tennant BC, Korba BE: Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks. ANTIMICROB AGENTS CHEMOTHER 49: 4396-4399, 2005.

Casey JL, Tennant BC, Gerin JL: Genetic changes in hepatitis delta virus from acutely and chronically infected woodchucks. J VIROL 80:: 6469-77, 2006.