Department of Biomedical Sciences

Selected Publications

1. Hesse, M, A Raulf, G Pilz, C Haberlandt, AM Klein, R Jabs, H Zaehres, CJ Fugemann, K Zimmermann, J Trebicka, A Welz, A Pfeifer, W Roll, MI Kotlikoff C Steinhauser, M Gotz, HR Scholer, and BK Fleischmann. High resolution of the cell cycle M-phase for direct visualization of cell division. Nature Communications (in press).

2. Jesty, SA, MA Steffey, FK Lee, M Breitbach, M Hesse, S Reining, JC Lee, RM Doran, AY Nikitin, BK Fleischmann, and MI Kotlikoff. Cardiovascular precursors support postinfarction myogenesis in the neonatal, but not the adult, heart. Proc Natl Acad Sci. USA, 109:13380-13385, 2012.

3. Shiba, Y, S Fernandes, W-Z Zhu, D Filice, V Muskheli, J Kim, NJ Palpant, J Gantz, KW Moyes, H Reinecke, BV Biber, T Dardas, JL Mignone, A Izawa, R Hanna, M Viswanathan, JD Gold, MI Kotlikoff, N Sarvazyan, MW Kay, CE Murry, and MA Laflamme. Human ESC-derived cardiomyocytes electrically integrate and suppress arrhythmias in injured hearts. Nature 1038:11317, 2012.

4. Risebro, CA, LK Petchey, N Smart, J Gomes, J Clark, JM Vieira, J Yanni, H Dobrzynski, S Davidson, Z Zuberi, A Tinker, B Shui, YI Tallini, MI Kotlikoff, L Miquerol, RJ Schwartz, and PR Riley. Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3. Circ. Res. 111:19-31, 2012.

5. Sonkusare, SK, AD Bonev, J Ledoux, MI Kotlikoff, DC Hill-Eubanks, MT Nelson. Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. Science 336:597-601, 2012.

6. Shui, B, A Ozer, W Zipfel, N Sahu, A Singh, J Lis, H Shi, MI Kotlikoff. RNA Aptamers that Functionally Interact with Green Fluorescent Protein and Its Derivatives. Nucleic Acids Res 40:e39, 2012.

7. Wang Q, Byrnes LJ, Shui B, Röhrig UF, Singh A, Chudakov DM, Lukyanov S, Zipfel WR, Kotlikoff MI, Sondermann H. Molecular mechanism of a green-shifted, pH-dependent red fluorescent protein mKate variant. PLoS One 6:e23513, 2011.

8. Shui B, Q Wang, F Lee, LJ Byrnes, DM Chudakov, SA Lukyanov, H Sondermann, MI Kotlikoff. Circular permutation of red fluorescent proteins. PLoS One 6(5):e20505, 2011.

9. Tallini, Y, KS Greene, M Craven, A Spealman, M Hesse, J Smith, A Woods, B Singh, A Yen, B Fleischman, and MI Kotlikoff. c-kit+ precursors in the neonatal heart specify all cardiac lineages. Proc Natl Acad Sci 106:1808-13, 2009.

10. Wang, Q, B Shui, MI Kotlikoff, H Sondermann. Structural basis for calcium sensing by GCaMP2. Structure 16:1817-1827, 2008.

11. Ledoux, J, MS Taylor, AD Bonev, RM Hannah, V Solodushko, B Shui, YN Tallini, MI Kotlikoff, MT Nelson. Functional architecture of IP3 signaling in restricted spaces of myoendothelial projections. Proc Natl Acad Sci 105:9627-32, 2008.

12. Tallini, YN, JF Brekke, B Shui, R Doran, SM Hwang, J Nakai, G Salama, S Segal, MI Kotlikoff. Propagated endothelial Ca2+ waves and arterioloar dilation in vivo: measurements in Cx40BAC-GCaMP2 transgenic mice. Circ Research 101:1300-1309, 2007.

13. Roell, W, T Lewalter, B-R Choi, B-R, YN Tallini, T Bostani, U Becher, P Sasse, S-M Hwang, R Doran, M Breitbach, S Reining, B Gabris, A Welz, G Salama, JW Schrickel, MI Kotlikoff, BK Fleischmann. Engraftment of electrically coupled cells in the heart prevents post -infarct ventricular arrhythmias. Nature 450:819-824, 2007.

14. Kotlikoff MI. Genetically encoded Ca2+ indicators: using genetics and molecular design to understand complex physiology. J. Physiol. 578:55-67, 2007

15. Tallini, NY, M Ohkura, B-R Choi, G Ji, K Imoto, R Doran, J Lee, P Plan, J Wilson, H-B Xin, A Sanbe, J Gulick, J Robbins, G Salama, J Nakai, and MI Kotlikoff. Imaging Cellular Signals in the Heart in Vivo: Cardiac expression of the high signal Ca2+ indicator GCaMP2. Proc Natl Acad Sci 103:4753-4758, 2006.

16. Xin, H-B, KY Deng, B Shui, S Qu, Q Sun, J Lee, KS Greene, J Wilson, Y Yu, M Feldman, and MI Kotlikoff. Gene trap and gen inversion methods for conditional gene inactivation in the mouse. Nucleic Acids Research, 33:e14,1-10 2005.

17. Xin, H-B, T Senbonmatsu, D Cheng, Y-X Wang, J Copello, G Ji, ML Collier, K-Y Deng, LH Jeyakumar, MA Magnuson, T Inagami, MI Kotlikoff, and S Fleischer. Estrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature, 416:334-337, 2002.