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Scott Coonrod, Ph.D.

Judy Wilpon Professor of Cancer Biology

Searching for simpler and targeted treatments for common cancers

Dr. Scott Coonrod focuses his research attention on cancer, the out-of-control growth of cells that claims millions of animal and human lives every year.

  • Finding smarter treatments for a canine cancer. In a dog-focused collaboration with Dr. Charles Danko, Dr. Gerlinde Van de Walle, and Dr. Roy Cohen, Coonrod’s laboratory is working to find targeted treatments for hemangiosarcoma, a common and often untreatable form of cancer in dogs. Using new sequencing technologies developed in Danko’s laboratory and mouse cancer models, Coonrod’s team is identifying the genes that make these tumors tick, then they aim to test drugs specifically intended to target the pathways that those genes control.

  • Outsmarting cancer drug resistance. The drug tamoxifen is often given to women following treatment for breast cancer to prevent the cancer from coming back, but breast cancer cells often become resistant to the drug. In another collaboration with the Danko laboratory, Coonrod is identifying the genes that make tamoxifen resistance possible in order to 1) stop those genes from making the switch to resistance, and 2) help identify cancer patients most at risk of tamoxifen resistance so that they can receive more effective alternative therapies.

  • Treatments for mammary cancer. In ongoing work, Coonrod and his team are testing a new therapy for treating mammary cancer in animals and humans alike. The early results are promising and the drug may be headed to clinical trials in dogs soon.

Selected Publications:

Links and abstracts for all of Dr. Coonrod's publications can be found at NCBI.

1.  Lata, JP; Gao, L; Mukai, C; Cohen, R; Nelson, JL; Anguish, L; Coonrod, SA; Travis, AJ. (2015). Effects of Nanoparticle Size on Multilayer Formation and Kinetics of Tethered Enzymes. Bioconjugate Chemistry, 26(9), 1931-38.

2. Choi, S; Coonrod, SA; Estroff, L; Fischbach, C. (2015). Chemical and physical properties of carbonated hydroxyapatite affect breast cancer cell behavior. (2015). Acta Biomaterialia, 24, 333-42.

3. Horibata, S; Vo, TV; Subramanian, V; Thompson, PR; Coonrod, SA. Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells. Journal of Visualized Experiments, (99).

4. Slade, DJ; Fang, P; Dreyton, CJ; Zhang, Y; Fuhrmann, J; Rempel, D; Bax, BD; Coonrod, SA; Lewis, HD; Guo, M; Gross, ML; Thompson, PR. (2015). Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design. ACS Chemical Biology, 10(4), 1043-53.

5. Subramanian, V; Knight, JS; Parelkar, S; Anguish, L; Coonrod, SA; Kaplan, MJ; Thompson, PR. (2015). Design, Synthesis, and Biological Evaluation of Tetrazole Analogs of CI-Amidine as Protein Arginine Deiminase Inhibitors. Journal of Medicinal Chemistry, 58(3), 1337-44.

6. McElwee, JL; Mohanan, S; Horibata, S; Sams, KL; Anguish, LJ; McLean, D; Cvitas, I; Wakshlag, JJ; Coonrod, SA. (2014). PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin Neoplasia. Cancer Research, 74(21), 6306-6317. 

7. Guertin, MJ; Zhang, X; Anguish, L; Kim, S; Varticovski, L; Lis, JT; Hager, GL; Coonrod, SA (2014). Targeted H3R26 Deimination Specifically Facilitates Estrogen Receptor Binding by Modifying Nucleosome Structure. PLoS Genetics, 10(9).