Cornell Feline Health Center

Cornell Feline Health Center Research Grants Program

The Cornell Feline Health Center Research Grants Program is an annual competitive grants program that provides up to $50,000 to researchers at the Cornell University College of Veterinary Medicine for the study of health issues that directly affect feline welfare. Grants are reviewed by the College’s Scientific Review Committee and are awarded on the basis of scientific merit, feasibility of the proposed project, and potential for impact of the project on feline health, among other aspects.

Research projects supported by the Center’s Research Grants Program have resulted in a broad spectrum of discoveries that have directly impacted our ability to diagnose and treat important feline diseases.

Below is a list of some of the scientific publications that have resulted from donor-sponsored research through this innovative program:

Comparison of glomerular filtration rate determined by use of single-slice dynamic computed tomography and scintigraphy in cats.
Schmidt DM, Scrivani PV, Dykes NL, Goldstein RM, Erb HN, Reeves AP.
Am J Vet Res. 2012 Apr;73(4):463-9.

Evaluation of serum iohexol clearance for use in predicting carboplatin clearance in cats.
Bailey DB, Rassnick KM, Prey JD, Dykes NL.
Am J Vet Res. 2009 Sep;70(9):1135-40.

Identification of regions and residues in feline junctional adhesion molecule required for feline calicivirus binding and infection.
Ossiboff RJ, Parker JS.
J Virol. 2007 Dec;81(24):13608-21. Epub 2007 Oct 3.

Feline caliciviruses (FCVs) isolated from cats with virulent systemic disease possess in vitro phenotypes distinct from those of other FCV isolates.
Ossiboff RJ, Sheh A, Shotton J, Pesavento PA, Parker JS.
J Gen Virol. 2007 Feb;88(Pt 2):506-17.

Conformational changes in the capsid of a calicivirus upon interaction with its functional receptor.
Ossiboff RJ, Zhou Y, Lightfoot PJ, Prasad BV, Parker JS.
J Virol. 2010 Jun;84(11):5550-64. Epub 2010 Mar 31.

The relationship of mucosal bacteria to duodenal histopathology, cytokine mRNA, and clinical disease activity in cats with inflammatory bowel disease.
Janeczko S, Atwater D, Bogel E, Greiter-Wilke A, Gerold A, Baumgart M, Bender H, McDonough PL, McDonough SP, Goldstein RE, Simpson KW.
Vet Microbiol. 2008 Apr 1;128(1-2):178-93. Epub 2007 Oct 22.

Subnormal concentrations of serum cobalamin (vitamin B12) in cats with gastrointestinal disease.
Simpson KW, Fyfe J, Cornetta A, Sachs A, Strauss-Ayali D, Lamb SV, Reimers TJ.
J Vet Intern Med. 2001 Jan-Feb;15(1):26-32.

Association of Helicobacter with cholangiohepatitis in cats.
Greiter-Wilke A, Scanziani E, Soldati S, McDonough SP, McDonough PL, Center SA, Rishniw M, Simpson KW.
J Vet Intern Med. 2006 Jul-Aug;20(4):822-7.

Histopathologic features, immunophenotyping, clonality, and eubacterial fluorescence in situ hybridization in cats with lymphocytic cholangitis/cholangiohepatitis.
Warren A, Center S, McDonough S, Chiotti R, Goldstein R, Meseck E, Jacobsen M, Rowland P, Simpson K.
Vet Pathol. 2011 May;48(3):627-41. Epub 2010 Nov 19.

Resting energy expenditure per lean body mass determined by indirect calorimetry and bioelectrical impedance analysis in cats.
Center SA, Warner KL, Randolph JF, Wakshlag JJ, Sunvold GD.
J Vet Intern Med. 2011 Nov-Dec;25(6):1341-50. doi: 10.1111/j.1939-1676.2011.00824.x. Epub 2011 Nov 1.

Phase I and pharmacokinetic evaluation of the combination of orally administered docetaxel and cyclosporin A in tumor-bearing cats.
McEntee MC, Rassnick KM, Bailey DB, Balkman CE, Flanagan JL, Beaulieu BB, Zgola MM, Lewis LD, Page RL.
J Vet Intern Med. 2006 Nov-Dec;20(6):1370-5.

Recipient preparation and mixed germ cell isolation for spermatogonial stem cell transplantation in domestic cats.
Kim Y, Selvaraj V, Dobrinski I, Lee H, McEntee MC, Travis AJ.
J Androl. 2006 Mar-Apr;27(2):248-56. Epub 2005 Nov 22.

Effect of donor age on success of spermatogenesis in feline testis xenografts.
Kim Y, Selvaraj V, Pukazhenthi B, Travis AJ.
Reprod Fertil Dev. 2007;19(7):869-76.

Expression, bioactivity, and clinical assessment of recombinant feline erythropoietin.
Randolph JE, Scarlett JM, Stokol T, Saunders KM, MacLeod JN.
Am J Vet Res. 2004 Oct;65(10):1355-66. Erratum in: Am J Vet Res. 2004 Nov;65(11):1572.

Descriptive epidemiology of feline upper respiratory tract disease in an animal shelter.
Dinnage JD, Scarlett JM, Richards JR.
J Feline Med Surg. 2009 Oct;11(10):816-25.

Effects of administration of fluids and diuretics on glomerular filtration rate, renal blood flow, and urine output in healthy awake cats.
McClellan JM, Goldstein RE, Erb HN, Dykes NL, Cowgill LD.
Am J Vet Res. 2006 Apr;67(4):715-22.

Association of the risk of development of hypothyroidism after iodine 131 treatment with the pretreatment pattern of sodium pertechnetate Tc 99m uptake in the thyroid gland in cats with hyperthyroidism: 165 cases (1990-2002).
Nykamp SG, Dykes NL, Zarfoss MK, Scarlett JM.
J Am Vet Med Assoc. 2005 May 15;226(10):1671-5.

Accuracy of increased thyroid activity during pertechnetate scintigraphy by subcutaneous injection for diagnosing hyperthyroidism in cats.
Page RB, Scrivani PV, Dykes NL, Erb HN, Hobbs JM.
Vet Radiol Ultrasound. 2006 Mar-Apr;47(2):206-11.

Purified feline and canine transferrin receptors reveal complex interactions with the capsids of canine and feline parvoviruses that correspond to their host ranges.
Palermo LM, Hafenstein SL, Parrish CR.
J Virol. 2006 Sep;80(17):8482-92.

Residues in the apical domain of the feline and canine transferrin receptors control host-specific binding and cell infection of canine and feline parvoviruses.
Palermo LM, Hueffer K, Parrish CR.
J Virol. 2003 Aug;77(16):8915-23.

Combinations of two capsid regions controlling canine host range determine canine transferrin receptor binding by canine and feline parvoviruses.
Hueffer K, Govindasamy L, Agbandje-McKenna M, Parrish CR.
J Virol. 2003 Sep;77(18):10099-105.

Single-dose pharmacokinetics and genotoxicity of metronidazole in cats.
Sekis I, Ramstead K, Rishniw M, Schwark WS, McDonough SP, Goldstein RE, Papich M, Simpson KW.
J Feline Med Surg. 2009 Feb;11(2):60-8. Epub 2009 Jan 19.

Below is a list of some of the presentations and book chapters that have resulted from donor-sponsored research:

"Susceptibility of the Intact and Traumatized Feline Cornea to In Vitro Binding and Invasion by Acanthamoeba castellanii"
Eric C. Ledbetter1A, Longying Dong1B, Sung G. Kim2.
AClinical Sciences, BBiomedical Sciences, 1Cornell University, Ithaca, NY; 2Division of Microbiology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR.; 2011 Association for Vision and Ophthalmology Conference, Ft. Lauderdale, Florida, May 5, 2011. Abstract.

"Activation of viral envelope proteins by host cell proteases: tales from influenza and coronaviruses"
Gary R. Whittaker
2010 (July), Gordon Research Conference on proprotein processing, trafficking, and secretion, New London, NH.

"Mutations in type I feline coronavirus spike protein associated with feline infectious peritonitis"
Jean Millet (Whittaker lab)
2011 (June), XIIth International Nidovirus Symposium, Traverse City, MI.

"Pathogenicity of feline coronavirus is associated with mutations at a conserved furin cleavage site of the spike viral envelope glycoprotein"
Jean Millet (Whittaker lab)
2012 (July), American Society for Virology Meeting, Madison WI.

A Comparison of Cyproheptadine and Clomipramine for the Treatment of Spraying Cats.
In: Overall KL, Mills DS, Heath SE, Horwitz D, editors.
Kroll T, Houpt KA (2001)
Proceedings of the 3rd International Congress of Veterinary Behavioural Medicine.
Potters Bar: Universities Federation for Animal Welfare. pp. 184–185.

"Detection of biofilm formation and nanobacteria under long-term cell culture conditions in serum samples of cattle, goats, cats, and dogs"
Barr SC, Linke RA, Janssen D, Guard CL, Smith MC Daugherty CS, et al.
(2003), Am J Vet Res 64: 176–182.

"Detection and pathogenic role of amoebae in feline corneal disease"
Ledbetter EC, Kim SG, Rohela M, Schaefer DMW
Vet Ophthalmol 2010; 13 (6): Abstract 021.