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The relationship between peptidylarginine deiminase (PAD) enzymes and canine and feline mammary cancer

We are investigating the relationship between peptidylarginine deiminase (PAD) enzymes and canine and feline mammary cancer. Specifically, we are exploring how the histone-modifying activity of PAD enzymes may contribute to mammary cancer development. This enzymatic activity, while generally low in healthy cells, tends to increase during cancer development. Because disruption of PAD activity with inhibitors presents a promising opportunity for improved mammary cancer therapies, we also are studying how PAD inhibitors affect the growth and migration of feline and canine mammary cancer cells. This research is done in close collaboration with the Coonrod lab, who have a lot of experience with PAD enzymes and their role in human breast cancer.