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Virus structure-receptor and antibody interactions

Our studies of virus capsid structure are looking at the flexibility and structural variation of the capsid using a variety of approaches - such as sequence-specific antibodies, proteases, and isoelectric focusing. We are also using X-ray crystallography in close collaboration with Drs. Michael Rossmann and Susan Hafenstein at Purdue University. We prepare capsids at Cornell and crystallize those under a variety of conditions (low pH, with EGTA, etc.) and then those are frozen, and the diffraction data is collected at the Cornell High Energy Synchrotron Source (CHESS) F1 beam line, or at the Advanced Photon Source. Other studies include cryoEM analysis of virus bound to different antibodies, as well as viral capsids bound to purified transferrin receptors.