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Transferrin receptor and viral capsids

Mutational analysis of the feline TfR and mapping using canine and feline TfR chimeras shows that the changes in the apical domain of the receptor determine the interaction with the capsid. Our recent work looking at the specific interactions of the feline and canine TfRs with the capsids of the different viruses shows that the interactions differ between different viruses and mutant forms of the TfR. The apical domain of the feline TfR interacts with CPV and FPV capsids.