Baker Institute for Animal Health
235 Hungerford Hill Road
Ithaca, NY 14853
Phone: (607) 256-5610
Fax: (607) 256-5608
Mutational analysis of the feline TfR and mapping using canine and feline TfR chimeras shows that the changes in the apical domain of the receptor determine the interaction with the capsid. Our recent work looking at the specific interactions of the feline and canine TfRs with the capsids of the different viruses shows that the interactions differ between different viruses and mutant forms of the TfR. The apical domain of the feline TfR interacts with CPV and FPV capsids.