Baker Institute for Animal Health
235 Hungerford Hill Road
Ithaca, NY 14853
Phone: (607) 256-5617
Fax: (607) 256-5608
Seeking ways to treat cancer, fight viruses and to improve wound healing
A main focus of Dr. Gerlinde Van de Walle’s research is exploring novel treatments for animal diseases. Currently, her lab is focused on finding drugs suitable for eliminating mammary cancer and ocular herpevirus infections in small companion animals, and evaluating the effectiveness of stem cell therapies for treating skin wounds in horses – all of which may also be used in humans and other animals.
1. Bussche, L; Rauner, G; Antonyak, M; Syracuse, B; McDowell, M; Brown, AM; Cerione, RA; Van de Walle, GR (2016). Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth. The Journal of Biological Chemistry, 291(47), 24390-24405.
2. Pennington, MR; Curtis, TM; Divers, TJ; Wagner, B; Ness, SL; Tennant, BC; Van De Walle GR (2016). Equine Mesenchymal Stromal Cells from Different Sources Efficiently Differentiate into Hepatocyte-Like Cells. Tissue Engineering: Part C, 22(6), 596-607.
3. Harman, RM; Curtis, TM; Argyle, DJ; Coonrod, SA; Van de Walle, GR (2016). A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species. Journal of Mammary Gland Biology and Neoplasia, 21(1-2), 51-66.
4. Pennington, MR; Fort, MW; Ledbetter, EC; Van de Walle, GR (2016). A novel corneal explant model system to evaluate antiviral drugs against feline herpesvirus type 1 (FHV-1). The Journal of General Virology, 97(6), 1414-25.
5. Bussche, L; Harman, RM; Syracuse, BA; Plante, EL; Lu, YC; Curtis, TM; Ma, M; Van de Walle, GR (2015). Microencapsulated equine mesenchymal stromal cells promote cutaneous wound healing in vitro. Stem Cwell Research & Therapy, 6:66.
6. Bussche L, Van de Walle GR (2014) Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion in the Equine Model. Stem Cells Translational Medicine, 3(12):1514-25. Abstract.
7. Harman, RM; Bussche, L; Ledbetter, EC; Van de Walle, GR (2014). Establishment and characterization of an air-liquid canine corneal organ culture model to study acute herpes keratitis. Journal of Virology, 88(23), 13669-13677.
Links and abstracts for all of Dr. Van de Walle’s publications can be found at PubMed.