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Dr. Tait Wojno discusses her work in a video from our online annual report. Read more about her work in the report.

Elia and black labDNA containers Scientist looking into microscope

Elia Tait Wojno, Ph.D.

Assistant Professor of Microbiology and Immunology

Allergies: How the immune system can make your pet miserable

Dr. Elia Tait Wojno explores the immune system when it functions correctly (to eliminate parasites) and also when it malfunctions (resulting in allergic disease).

  • Similarities between dog and human allergies. Tait Wojno and her team have studied blood samples from dozens of canine patients at the Cornell University Hospital for Animals, including dogs with skin itching, redness, rashes, and other allergic signs, and dogs without allergies. They found that allergic dogs have a specific type of immune cell in their blood, cells also found in allergic humans and mice. The discovery means that human treatments for these types of allergic signs could also work in canine medicine.

  • Studying how lipids and proteins affect inflammation during infection and allergy. Tait Wojno is exploring how the oily molecules called lipids and other protein molecules called cytokines affect the process of inflammation. Inflammation causes some of the signs and symptoms of allergic disease but helps the body fight infection with parasitic worms. Understanding how lipids and cytokines work to control inflammation will inform the development of new drugs that target these factors to treat allergies or fight parasitic infections. 

  • Exploring how the immune system develops. In collaboration with scientists here at Cornell and at the University of Rochester, Tait Wojno’s laboratory has begun studying how the cells of the immune system develop over a lifetime and what happens to make it all work correctly in animals and humans of different ages.

Publications:

Links and abstracts for all of Dr. Tait Wojno's publications can be found at NCBI.

1. Tait Wojno, ED; Artis, D. (2016). Emerging concepts and future challenges in innate lymphoid cell biologyThe Journal of Experimental Medicine, 213(11), 2229-2248. 

2. Monticelli, LA; Buck, MD; Flamar, AL; Saenz, SA; Tait Wojno, ED; Yudanin, NA; Osborne, LC; Hepworth, MR; Tran, SV; Rodewald, HR; Shah, H; Cross, JR; Diamond, JM; Cantu, E; Christie, JD; Pearce, EL; Artis,D. (2016). Arginase 1 is an innate lymphoid cell-intrinsic metabolic checkpoint controlling type 2 inflammationNature Immunology, 17(6):656-665.

3. Tait Wojno, ED. (2016). Innate lymphoid cells: an emerging population in type 2 inflammation.  WC Gause & D Artis (Eds.), The Th2 Type Immune Response (pp. 13-31). New York, NY: Springer.

4. Tait Wojno, ED; Monticelli, LA; Tran, SV; Alenghat, T; Osborne, LC; Thome, JJ; Willis, C; Budelsky, A; Farber, DL; Artis, D. (2015). The prostaglandin D22 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. Mucosal Immunology, 8(6), 1313-1323.  

5. Kim, BS; Wang, K; Siracusa, MC; Saenz, SA; Brestoff, JR; Monticelli, LA; Noti, M; Tait Wojno, ED; Fund, TC; Kubo, M; Artis, D. (2014).  Basophils promote innate lymphoid cell responses in inflamed skin Journal of Immunology, 193(7), 3717-3725.

6. Siracusa, MC; Saenz, SA; Tait Wojno, ED; Kim, BS; Osborne, LC; Ziegler, CG; Benitez, AJ; Ruymann, KR; Farber, DL; Sleiman, PM; Hakonarson,H; Cianferoni, A; Wang, ML; Spergel, JM; Comeau, MR; Artis, D. (2013).  Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammationImmunity, 39(6), 1158-1170.

7. Tait Wojno, ED;*, Noti, M;*, Kim, BS; Siracusa, MC; Giacomin, PR; Nair, MG; Benitez, AJ; Ruymann, KR; Muir, AB; Hill, DA; Chikwava, KR; Moghaddam, AE; Sattentau, QJ; Alex, A; Zhou, C; Yearley, JH; Menard-Katcher, P; Kubo, M; Obata-Ninomiya, K; Karasuyama, H; Comeau, MR; Brown-Whitehorn, T; Malefyt, R; Sleiman, PM; Hakonarson, AC; Falk, GW; Wang, ML; Spergel, JM; Artis, D.  (2013).  TSLP-elicited basophil responses promote eosinophilic esophagitis. Nature Medicine, 19(8), 1005-1013.  * These authors contributed equally.