Biological and Biomedical Sciences Graduate Program

genome  

Medical Genetics & Genomics

Many diseases have a genetic basis with either simple (one gene) or complex (many genes) inheritance. Breeds of companion, domestic or lab animals often have genetic predisposition to diseases as an inadvertent consequence of inbreeding. Researchers at Cornell are using modern genomic technologies to pinpoint genetic variants that underlie a variety of breed-specific diseases of animals, such as cancers and heart diseases of dogs, immune diseases in horses, and reproductive disorders in mice. Ultimately, our researchers hope to use the genetic discoveries for early intervention, stem cell treatment, selective breeding, and application to human disease.

Faculty Research area Graduate Field Membership (Follow links to the Biological & Biomedical Sciences Fields)
angert
Esther Angert
Comparative genomics of bacterial developmental systems, genomic analysis of symbiotic microbes, molecular evolution Genomics; Microbiology
Doug Antcazk
Doug Antczak
pregnancy immunology; immunogenetics; equine immunology Comparative Biomedical Sciences;
Immunology & Infectious Disease; Genomics; Molecular & Integrative Physiology
Boyko
Dr. Adam Boyko
genomic investigation of dogs as a model of genetic disease and evolutionary genetics Comparative Biomedical Sciences; Computational Biology; Genomics; Molecular & Integrative Physiology; Genetics, Genomics & Development
nb
Nicolas Buchon
Host/Microbe relationships and Control of intestinal stem cell behavior in homeostasis and disease Comparative Biomedical Sciences;
Entomology;
Genetics, Genomics & Development;              Microbiology
Sharon A. Center
Sharon A. Center
liver and kidney diseases of small animals Comparative Biomedical Sciences
Yung-Fu Chang
Yung-Fu Chang
mechanisms of infection, particularly leptospira and salmonella Comparative Biomedical Sciences;
Zoology & Wildlife Conservation;               Immunology & Infectious Disease
Ruth Collins
Ruth Collins
pharmacology; cancer cell biology; small GTPase regulation of intracellular traffic and cellular growth control Comparative Biomedical Sciences;
Microbiology;
Pharmacology
;
Biochemistry, Molecular & Cell Biology;
Genomics;
Neurobiology & Behavior
Scott Coonrod
Scott Coonrod
reproductive physiology; molecular and cellular physiology; epigenetic reprogramming during the egg-to-embryo transition; mechanisms by which specific histone modifications are dynamically regulated during hormone-dependent gene transcription in breast cancer cells Comparative Biomedical Sciences;
Molecular & Integrative Physiology;        Pharmacology
Matthew DeLisa
Matthew DeLisa
molecular biotechnology; protein biogenesis and folding pathways; protein engineering Comparative Biomedical Sciences;
Microbiology;
Biomedical Engineering;
Chemical Engineering
Maria Julia Bevilaqua Felippe
Maria Julia Bevilaqua Felippe
cellular and molecular mechanisms involved in B-cell response; neonatal immunology and response to vaccination; immunomodulation using biologic response modifiers; cancer immunotherapy; characterization of primary and secondary immunodeficiencies Comparative Biomedical Sciences;
Immunology & Infectious Disease
Maria Garcia-Garcia
Maria Garcia-Garcia
developmental biology in mice and flies; genetics of developmental mechanisms that influence embryonic morphology Comparative Biomedical Sciences;
Molecular & Integrative Physiology;
Biochemistry, Molecular & Cell Biology;
Genetics, Genomics and Development
Michael I. Kotlikoff
Michael I. Kotlikoff
muscle biology; mouse genetics; molecular imaging; ion channels; physiological genomics; cellular signaling; genetic cell sensors; conditional gene targeting Comparative Biomedical Sciences;
Molecular & Integrative Physiology;
Pharmacology;
Biophysics;
Genomics;
Neurobiology & Behavior
Natasza Kurpios
Natasza Kurpios
tissue morphogenesis; cell shape and architecture; organ development; gut morphogenesis; mammary gland biology; breast cancer Molecular & Integrative Physiology;
Pharmacology;                                                Comparative Biomedical Sciences;
Genetics, Genomics and Development
lazzaro
Brian Lazzaro
Virology, Feline Calicivirus, Mammalian Orthoreoviruses, Virus-host interactions, Effect of viral infection on host cell translation, use of viruses for treatment of cancer, virus entry, broadly neutralizing antibodies Comparative Biomedical Sciences;                       Ecology and Evolutionary Biology;                       Entomology;                                                            Genetics, Genomics, and Development
Siu Syliva Lee
Siu Sylvia Lee
molecular genetics of aging; signaling pathways of nutrient sensing; molecular basis of stress response Comparative Biomedical Sciences; Biochemistry, Molecular & Cell Biology;
Computational Biology;
Genetics, Genomics and Development;
Nutrition
libert
Sergiy Libert
Mice; molecular biology of aging, age-associated diseases, cancer, neurodegeneration; anorexia, energy metabolism,

Comparative Biomedical Sciences;                  Molecular & Integrative Physiology;
Biochemistry, Molecular and Cell Biology                   Genetics, Genomics and Development

David Lin
David Lin
axon guidance, neurodevelopment, epilepsy, autism, genomics Comparative Biomedical Sciences;
Molecular & Integrative Physiology;
Pharmacology;
Biochemistry, Molecular & Cell Biology;
Genetics, Genomics and Development;
Genomics; Neurobiology & Behavior
Vicki Meyers-Wallen
Vicki Meyers-Wallen
inherited canine diseases; reproductive tract disorders Comparative Biomedical Sciences;
Molecular & Integrative Physiology
N. Sydney Moise
N. Sydney Moise
arrhythmias; Sudden Death Syndrome; cardiology Comparative Biomedical Sciences
Mukai, Motoko
Motoko Mukai
endocrine disrupting compounds; neuroendocrine regulation; reproductive, developmental, and metabolic health effect of toxic compounds found in food Environmental Toxicology; Food Science & Technology
Alexander Nikitin
Alexander Nikitin
Stem cells and cancer. Pathogenesis of ovarian and prostate cancers. Modeling of human disease in genetically modified mice and human organoids. Comparative Biomedical Sciences;
Molecular & Integrative Physiology;
Biochemistry, Molecular and Cell Biology
Environmental Toxicology;                                      Genetics, Genomics and Development
Kimberly O'Brien
Kimberly O'Brien
calcium metabolism and bone health; control of maternal/fetal nutrient; partitioning and cellular mineral transport; micronutrient status in international settings; development of mass spectrometric methodology; pediatric bone health; pregnancy and mineral metabolism in adolescents Molecular & Integrative Physiology;
Nutrition
SQ
Shu-Bing Qian
Translational control of gene expression; signaling pathways in stress response; protein quality control in metabolic diseases.

Molecular & Integrative Physiology;                  Genetics, Genomics & Development

Dr. Kristy Richards
Kristy Richards

Immuno-oncology, monoclonal antibodies, genetic mechanisms of resistance, personalized medicine, comparative oncogenomics, novel therapeutic development
Comparative Biomedical Sciences
John Schimenti
John Schimenti
Genetics of reproduction and germ cell development; cancer genetics; meiosis; DNA repair; genome manipulation in mice; functional genomics. Comparative Biomedical Sciences;
Molecular & Integrative Physiology;
Biochemistry, Molecular & Cell Biology;
Genetics, Genomics and Development;
Genomics
Kenneth W. Simpson
Kenneth W. Simpson
gastroenterology Comparative Biomedical Sciences;              Immunology & Infectious Disease
Soloway
Paul Soloway
Epigenetic regulatory mechanisms in mammals Comparative Biomedical Sciences;
Genomics
;
Biochemistry, Molecular & Cell Biology;
Genetics, Genomics and Development;
Nutrition
Michael Stanhope
Michael Stanhope
molecular evolution and comparative genomics of infectious disease organisms Comparative Biomedical Sciences; Genomics
TM
Anna Thalacker-Mercer

Skeletal muscle metabolic and inflammatory dysfunction; muscle atrophy and hypertrophy in aging and disease; dynamics among amino acids, metabolites, and inflammation in the development of metabolic disease and sarcopenia

pending: Molecular & Integrative Physiology
Rory J. Todhunter
Rory J. Todhunter
canine hip dysplasia; genetic linkage analysis; osteoarthritis Comparative Biomedical Sciences
Gary R. Whittaker
Gary R. Whittaker

Pathogenesis of influenza viruses, corona viruses and arena viruses. Host range and receptors, activation of membrane fusion, macrophage- and neurotropism, anti-viral therapeutics, diagnostic tests, virus-bacteria co-infections

Comparative Biomedical Sciences; Immunology & Infectious Disease; Microbiology; Pharmacology; Biochemistry, Molecular & Cell Biology
Mariana Wolfner
Mariana Wolfner
Genetic, molecular, developmental, and evolutionary studies of seminal proteins' functions in fertility, and of mechanisms of egg activation and initiation of embryogenesis. We these investigate conserved phenomena in reproductive biology, using primarily the Drosophila model system. Comparative Biomedical Sciences; Molecular & Integrative Physiology; Biochemistry, Molecular & Cell Biology;
Ecology & Evolutionary Biology;
Genetics, Genomics and Development
Andrew Yen
Andrew Yen
leukemia; cell growth and differentiation; oncogenes/genetics Comparative Biomedical Sciences; Environmental Toxicology